Browsing by Author "Martínez, Jorge"

Now showing 1 - 9 of 9
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    Diarrea poscolecistectomía : ¿un problema frecuente?
    (2017) Manríquez, Erik; Tejos, Rodrigo; Rojas, Alejandro; Pimentel, Eduardo; Vega, Tomás; Achurra Tirado, Pablo; Avila, Rubén; Jarufe Cassis, Nicolás; Crovari Eulufi, Fernando; Arrese Jiménez, Marco; Martínez, Jorge
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    Disminución de la presión venosa central : efecto sobre el gasto cardíaco
    (2017) Concha P., Mario; Mertz K., Veronica; Cortínez Fernández, Luis Ignacio; Jarufe Cassis, Nicolás; Martínez, Jorge; Guerra, Juan Francisco; Carmona B., Javiera
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    Factores asociados a la sobrevida de los pacientes trasplantados hepáticos por hepatocarcinoma según los criterios de Milán.
    (2019) Pacheco, Sergio; Rodríguez, Javier; Briceño, Eduardo; Martínez, Jorge; Guerra, Juan Francisco; Jarufe Cassis, Nicolás
    Objetivo: determinar la sobrevida global de los pacientes sometidos a trasplante hepático(TH) por carcinoma hepatocelular (CHC) siguiendo los criterios de Milán (CM) y analizarlos factores asociados a la sobrevida.Material y método: Estudio de cohorte no concurrente. Se analizaron los pacientes sometidosa TH por CHC entre los años 2000 y 2016. Se realizó un análisis de los factores asociados ala sobrevida mediante Kaplan Meier, test de log-rank y regresión de Cox. Se considerósignificativo un valor de p menor a 0,05.Resultados: se realizaron un total de 50 TH por CHC. El promedio de edad fue de 60,8 ± 6,1años; 38 pacientes (76%) fueron de sexo masculino. En el análisis multivariable los factoresasociados a la sobrevida fueron el cumplimiento de los CM (Hazard ratio 0,104 IC95%0,017-0,637; p=0,01) y la ausencia de invasión vascular (Hazard ratio 0,050 IC95%0,008-0,306;p<0,01) en la biopsia del explante.Discusión: la sobrevida de los pacientes sometidos a TH por CHC en nuestro centro es similara lo reportado en la literatura internacional y se encuentra determinada por el cumplimientode los CM y la ausencia de invasión vascular en la biopsia de explante.
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    Glucose Promotes a Pro‐Oxidant and Pro‐Inflammatory Stromal Microenvironment Which Favors Motile Properties in Breast Tumor Cells
    (2017) Kallens, Violeta; Tobar, Nicolás; Molina, Jessica; Bidegain, Arantzazú; Smith, Patricio C.; Porras, Omar; Martínez, Jorge
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    Glycated Collagen Stimulates Differentiation of Gingival Myofibroblasts.
    (2017) Retamal, Ignacio N.; Hernández, Romina; Melo Ledermann, Francisco Javier; Zapata, Paulina; Martinez, Constanza; Martínez, Jorge; Smith, Patricio C.
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    Latin American Association for the Study of the Liver (ALEH) guidance of preoperative care in liver transplantation: referral criteria, patient assessment, and waiting list management
    (2025) Mainardi, Victoria; Pages, Josefina; Menéndez, Josemaría; Zapata, Rodrigo; Díaz Piga, Luis Antonio; Marciano, Sebastián; Cairo, Fernando; Padilla-Machaca, Martin; Tenorio, Laura; Urzúa, Álvaro; Navarro, Lucía; Domínguez, Nicolás; Coste, Pablo; Mendizábal, Manuel; Martínez, Jorge; López, Sergio; Varón, Adriana; Alfeu de Medeiros Fleck, jr; Abad Gonzáles, Jhon; Restrepo, Juan Carlos; Codes, Liana; Lisboa Bittencourt, Paulo; Pérez Figueroa, Norma Marlene; Castro-Narro, Graciela; Terrabuio, Débora Raquel B.; Pessoa, Mário Guimarães; Girala, Marcos; Schiavon, Leonardo Lucca; Aguilera, Edgard; Valenzuela Aguilera, Kenia; Samada, Marcia; Gerona, Solange; Villamil, Alejandra
    Liver transplantation (LT) is the standard of care therapy for patients with decompensated cirrhosis, early-stage hepatocellular carcinoma, acute liver failure, and other expanding indications. Latin America is a highly heterogeneous region characterized by an uneven distribution of socio-economic conditions and irregular access to health resources, and consequently LT activity varies across it. This current guidance of preoperative care in LT represents a collaborative effort to assess and standardize preoperative evaluation of liver transplant candidates in Latin America. It is the first position paper of the special interest group on LT of the Latin American Association for the Study of the Liver (ALEH), which draws evidence-based comprehensive recommendations regarding who to refer, the LT assessment and how to manage the patient on the waiting list, taking into consideration their applicability in Latin America.
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    Liposarcoma retroperitoneal gigante
    (2017) Pacheco, Sergio; Murcia, Eduar; Díaz, Cristián; Castillo, Erick; Briceño, Eduardo; Martínez, Jorge; Guerra, Juan Francisco; Jarufe Cassis, Nicolás
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    Soluble factors derived from tumor mammary cell lines induce a stromal mammary adipose reversion in human and mice adipose cells. Possible role of TGF-β1 and TNF-α
    (2009) Guerrero, Javier; Tobar, Nicolás; Cáceres, Mónica; Espinoza, Lorena; Escobar, Paula; Dotor, Javier; Smith Ferrer, Patricio Cristian; Martínez, Jorge
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    Trasplante hepático: Evolución, curva de aprendizaje y resultados después de los primeros 300 casos
    (2019) Quezada González, José Luis; Cancino, Alejandra; Arrese Jimenez, Marco Antonio; Wolff, Rodrigo; Benitez Gajardo, Carlos Esteban; Pattillo Silva, Juan Carlos; Gana Ansaldo, Juan Cristobal; Concha Pinto, Mario Rodrigo; Cortinez Fernandez, Luis Ignacio; Vera Alarcón, María Magdalena; Miranda, Paula; Rubilar, Francisco; Troncoso, Andrés; Briceno Valenzuela, Eduardo Andres; Dib Marambio, Martin Javier; Jarufe Cassis, Nicolas Patricio; Martínez, Jorge; Guerra Castro, Juan Francisco
    Liver transplantation (LT) is an option for people with liverfailure who cannot be cured with other therapies and for some people with liver cancer. Aim: To describe, and analyze the first 300 LT clinical results, andto establish our learning curve. Material and Methods: Retrospective cohortstudy with data obtained from a prospectively collected LT Program database.We included all LT performed at a single center from March 1994 to September2017. The database gathered demographics, diagnosis, indications for LT, surgicalaspects and postoperative courses. We constructed a cumulative summation testfor learning curve (LC-CUSUM) using 30-day post-LT mortality. Mortality at 30days, and actuarial 1-, and 5-year survival rate were analyzed. Results: A total of281 patients aged 54 (0-71) years (129 women) underwent 300 LT. Ten percentof patients were younger than 18 years old. The first, second and third indicationsfor LT were non-alcoholic steatohepatitis, chronic autoimmune hepatitis andalcoholic liver cirrhosis, respectively. Acute liver failure was the LT indication in51 cases (17%). The overall complication rate was 71%. Infectious and biliarycomplications were the most common of them (47 and 31% respectively). TheLC-CUSUM curve shows that the first 30 patients corresponded to the learningcurve. The peri-operative mortality was 8%. Actuarial 1 and 5-year survival rateswere 82 and 71.4%, respectively. Conclusions: Outcome improvement of a LTprogram depends on the accumulation of experience after the first 30 transplantsand the peri-operative mortality directly impacted long-term survival.