Browsing by Author "Martínez, Gonzalo"
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- ItemA MicroRNA Signature in Acute Coronary Syndrome Patients and Modulation by Colchicine(2020) Barraclough, J. Y.; Joglekar, M. V.; Januszewski, A. S.; Martínez, Gonzalo; Celermajer, D. S.; Keech, A. C.; Hardikar, A. A.; Patel, S.
- ItemAcceso radial derecho versus izquierdo para cateterismo coronario en pacientes mayores de 70 años(2016) Martínez, Gonzalo; Valdebenito, Martín; Méndez Lesser, Manuel; Martínez Sepúlveda, José Alejandro; Lindefjeld, Dante; Pérez, Osvaldo; Valdivia, Ursula; Unzueta, Catherine; Valenzuela, Edith
- ItemBasal autophagy protects cardiomyocytes from doxorubicin-induced toxicity(2016) Pizarro, Marcela; Troncoso, Rodrigo; Martínez, Gonzalo; Chiong, Mario; Castro Gálvez, Pablo Federico
- ItemCardiotoxicidad inducida por tratamientos oncológicos. Fundamentos para la implementación de equipos de Cardio-Oncología(2018) Hameau, René ; Gabrielli, Luigi; Garrido, Marcelo ; Guzmán, Ana María ; Retamal, Ignacio ; Vacarezza, María José; Greig, Douglas ; Ocqueteau, Mauricio; Sánchez, César; Pizarro, Marcela; Corvalán, Alejandro; Lavandero, Sergio; Castro, Pablo F.; Martínez, Gonzalo
- ItemCervical Artery Dissections with and without stroke, risk factors and prognosis : a Chilean prospective cohort(2020) Mazzon, E.; Rocha, D.; Brunser, A. M.; De la Barra, C.; Stecher, X.; Bernstein, T.; Zuniga, P.; Diaz, V.; Martínez, Gonzalo; Venturelli, P. M.
- ItemCholesterol Levels and the Association of Statins With In-Hospital Mortality of Myocardial Infarction Patients Insights From a Chilean Registry of Myocardial Infarction(2013) Martínez, Gonzalo; Rigotti Rivera, Attilio; Acevedo B., Mónica; Navarrete, Carlos; Rosales Núñez, Juan Elizabeth; Giugliano, Robert P, Corbalán Herreros, Ramón
- ItemColchicine acutely suppresses local cardiac production of inflammatory cytokines in patients with an acute coronary syndrome(2015) Martínez, Gonzalo; Robertson, S.; Barraclough, J.; Xia, Q.; Mallat, Z.; Bursill, C.; Celermajer, D.; Patel, S.
- ItemColchicine as a Novel Therapy for Suppressing Chemokine Production in Patients With an Acute Coronary Syndrome : A Pilot Study(2019) Tucker, Bradley; Kurup, Rahul; Barraclough, Jennifer; Henriquez, Rodney; Cartland, Siân; Arnott, Clare; Misra, Ashish; Martínez, Gonzalo; Kavurma, Mary; Patel, Sanjay
- ItemCombined total-arterial, off-pump coronary artery bypass grafting and transaortic transcatheter aortic valve implantation(2015) Seco, Michael; Martínez, Gonzalo; Edelman, J.; James, B.
- ItemCyclic Amp and the Reproductive Process of the Scallop Argopecten Purpuratus(1997) Martínez, Gonzalo; Inestrosa Cantín, Nibaldo
- ItemDesensibilización rápida en pacientes con hipersensibilidad a aspirina sometidos a angioplastía coronaria. Reporte de cuatro casos(2013) Veas P., Nicolas; Martínez, Gonzalo; Jalil Milad, Jorge; Martínez Sepúlveda, José Alejandro; Castro Gálvez, Pablo Federico
- ItemEnseñanza de auscultación cardiaca a estudiantes y residentes de medicina mediante el uso de un simulador de ruidos cardiacos(2012) Martínez, Gonzalo; Guarda Salazar, Eduardo Raimundo; Baeza Vergara, Ricardo Gabriel; Garayar Pulgar, Bernardita; Chamorro S., Gastón; Casanegra, Pablo
- Item¿Es Costo-Efectivo el Reemplazo Valvular Aórtico Percutáneo en Paciente con Estenosis Aórtica de muy Alto Riesgo Quirúrgico en Chile?(2015) Fajuri, Alejandro; Martínez, Gonzalo
- ItemExtracorporeal Membrane Oxygenation for Very High-risk Transcatheter Aortic Valve Implantation(2014) Seco, M.; Forrest, P.; Jackson, S.; Martínez, Gonzalo; Andvik, S.; Bannon, P.; Ng, M.; Fraser J.; Wilson, M.; Vallely, M.
- ItemHow should I treat a complex critical left main bifurcation lesion in a patient with poor left ventricular function, an occluded dominant right coronary artery and severe peripheral vascular disease?(2015) Martínez, Gonzalo; Molina, Javier; Byrom, Michael; Puranik, Rajesh; Bernard, N.G.; Bailey, Brian P.; Patel, Sanjay
- ItemInfarto Agudo al Miocardio en pacientes menores de 40 años. Características clínicas, angiográficas y alternativas terapéuticas(2013) Méndez Lesser, Manuel; Martínez, Gonzalo; Veas, N.; Pérez, Osvaldo; Lindefjeld, Dante; Winter, J. L.; Zuanic, K.; Martínez Sepúlveda, José Alejandro
- ItemIntroduction to an interdisciplinary heart team-based transcatheter aortic valve implantation programme : short and mid-term outcomes(2014) Martínez, Gonzalo; Seco, M.; Jaijee, S.K.; Adams, M.R.; Cartwright, B.L.; Forrest, P.; Celermajer, D.S.; Vallely, M.P.; Wilson, M.K.; Ng, M.K.C.
- ItemMid-term follow-up of balloon pulmonary angioplasty for inoperable chronic thromboembolic pulmonary hypertension : an experience in Latin America(2020) Sepúlveda Varela, Pablo Andrés; Hameau, R.; Backhouse, C.; Charme, G.; Pacheco, F.; Ramírez, P. A.; Fuenzalida Alarcón, Alberto Javier; Quitral, J.; Martínez, Gonzalo; Martínez Sepúlveda, José Alejandro
- ItemMonoamines and the Release of Gametes by the Scallop Argopecten Purpuratus(1996) Martínez, Gonzalo; Inestrosa Cantín, Nibaldo
- ItemMultimodal assessment of acute cardiac toxicity induced by thoracic radiotherapy in cancer patients : study protocol(2021) Merino Lara, Tomas Rodrigo; Pinto, Mauricio P.; Orellana Vargas, María Paz; Martínez, Gonzalo; Andía Kohnenkampf, Marcelo Edgardo; Muñoz Schuffenegger, Pablo; Acevedo Claros, Francisco Nicolás; Gabrielli, Luigi; Sánchez Rojel, César Giovanni; Pereira, JaimeBackground : Today, cancer ranks as one of the leading causes of death. Despite the large number of novel available therapies, radiotherapy (RT) remains as the most effective non-surgical method to cure cancer patients. In fact, approximately 50% of all cancer patients receive some type of RT and among these 60% receive RT-treatment with a curative intent. However, as occurs with any other oncological therapy, RT treated patients may experience toxicity side effects that range from moderate to severe. Among these, cardiotoxicity represents a significant threat for premature death. Current methods evaluate cardiotoxic damage based on volumetric changes in the Left Ventricle Ejected Fraction (LVEF). Indeed, a 10% drop in LVEF is commonly used as indicator of cardiotoxicity. More recently, a number of novel techniques have been developed that significantly improve specificity and sensitivity of heart’s volumetric changes and early detection of cardiotoxicity even in asymptomatic patients. Among these, the Strain by Speckle Tracking (SST) is a technique based on echocardiographic analysis that accurately evaluates myocardial deformation during the cardiac cycle (ventricular and atrial function). Studies also suggest that Magnetic Resonance Imaging (MRI) is a high-resolution technique that enables a better visualization of acute cardiac damage. Methodology: This protocol will evaluate changes in SST and MRI in cancer patients that received thoracic RT. Concomitantly, we will assess changes in serum biomarkers of cardiac damage in these patients, including: high-sensitivity cardiac Troponin-T (hscTnT), N-Terminal pro-Brain Natriuretic Peptide (NTproBNP) and Circulating Endothelial Cells (CECs), a marker of endothelial dysfunction and vascular damage. Discussion: The presented protocol is to our knowledge the first to prospectively and with a multimodal approach, study serological and image biomarkers off early cardiac damage due to radiotherapy. With a practical clinical approach we will seek early changes that could potentially be in the future be linked to clinical mayor events with consequences for cancer survivors.