Browsing by Author "Maria Edwards, Ana"

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    Riboflavin Surface Modification of Poly(vinyl chloride) for Light-Triggered Control of Bacterial Biofilm and Virus Inactivation
    (2021) Munoz, Marcelo; El-Khoury, Antony; Cimenci, Cagla Eren; Gonzalez-Gomez, Mayte; Hunter, Robert A.; Lomboni, David; Variola, Fabio; Rotstein, Benjamin H.; Vono, Lucas L. R.; Rossi, Liane M.; Maria Edwards, Ana; Alarcon, Emilio, I
    Poly(vinyl chloride) (PVC) is the most used biomedical polymer worldwide. PVC is a stable and chemically inert polymer. However, microorganisms can colonize PVC producing biomedical device-associated infections. While surface modifications of PVC can help improve the antimicrobial and antiviral properties, the chemically inert nature of PVC makes those modifications challenging and potentially toxic. In this work, we modified the PVC surface using a derivative riboflavin molecule that was chemically tethered to a plasma-treated PVC surface. Upon a low dosage of blue light, the riboflavin tethered to the PVC surface became photochemically activated, allowing for Pseudomonas aeruginosa bacterial biofilm and lentiviral in situ eradication.
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    Silica nanoreactors from silylated riboflavin for efficient singlet oxygen delivery
    (2014) Angeluzzi, Natalia C.; Munoz, Marcelo; Marquez, Daniela T.; Baptista, Mauricio S.; Maria Edwards, Ana; Alarcon, Emilio I.; Scaiano, Juan C.
    Silylation of riboflavin allowed its incorporation into spherical SiO2 nanoparticles that were able to generate singlet oxygen and oxidize human serum albumin while conferring riboflavin remarkable photostability.