Browsing by Author "Marghoob, Nadeem G."

Now showing 1 - 4 of 4
  • Thumbnail Image
    Item
    Assessment of the Safety Risk of Dermatoscope Magnets in Patients With Cardiovascular Implanted Electronic Devices
    (2018) Rishpon, Ayelet; Braun, Ralph; Weinstock, Martin A.; Kulju, Stephen; Grenga, Andrea; Navarrete Dechent, Cristián Patricio; Marghoob, Nadeem G.; Steffel, Jan; Marghoob, Ashfaq A.
  • No Thumbnail Available
    Item
    Bilateral diffuse uveal melanocytic proliferation with multifocal diffuse integumentary melanocytic proliferation paraneoplastic syndrome: A case report
    (2021) Navarrete-Dechent, Cristian; Monnier, Jilliana; Marghoob, Nadeem G.; Liopyris, Konstantinos; Busam, Klaus J.; Francis, Jasmine H.; Marghoob, Ashfaq A.
    Bilateral diffuse uveal melanocytic proliferation (B-DUMP) is a rare paraneoplastic syndrome typically presenting with bilateral visual loss. B-DUMP is associated with extraocular systemic malignancies with the most common being lung cancer in males and uro-gynaecological cancer in females (mainly ovarian cancer). Cutaneous and/or mucosal involvement in patients with B-DUMP has been reported but it is not well characterised. Herein, we present a female in her 70s with diagnosis of stage IV vaginal clear-cell carcinoma and metastatic melanoma of unknown primary that developed progressive bilateral loss of visual acuity compatible with `B-DUMP'. Simultaneously, she developed multifocal bilateral bluish-greyish patches on the skin that were shown to have a proliferation of dermal melanocytes. We propose that the clinical and histopathologic cutaneous findings seen in patients with B-DUMP be termed 'diffuse integumentary melanocytic proliferation (DIMP)'.
  • No Thumbnail Available
    Item
    Paradoxical effect of epinephrine on lesion redness and vascularity
    (2023) Nazir, Zaeem H.; Rishpon, Ayelet; Kose, Kivanc; Marghoob, Nadeem G.; Liopyris, Konstantinos; Navarrete-Dechent, Cristian; Dusza, Stephen W.; Daoud, Alexander; Marghoob, Ashfaq A.
    IntroductionEpinephrine is commonly used in combination with local anesthetic (lidocaine/epinephrine) due to its beneficial vasoconstrictive properties. Typically, pallor is appreciated after injection as a sign of effect; however, we observed that some cutaneous malignancies paradoxically revealed increased redness and vascularity after injection of lidocaine/epinephrine. In this study, we investigate this phenomenon among a series of biopsied lesions to identify characteristics of lesions associated with increased redness and/or vascularity.ObjectivesTo determine characteristics of lesions which become redder or more vascular after injection with lidocaine/epinephrine prior to biopsy.MethodsThis cross-sectional study consisted of a convenience sample of lesions scheduled for biopsy. Lesions were photographed prior to and 7 min after injection of lidocaine/epinephrine as a part of standard care. Two readers blinded to study objectives and histopathological diagnosis assessed lesions for changes in redness and vascular features.ResultsFifty-four lesions from 47 patients-61.7% male, mean age 64.8 years, age-range 24-91 were included. Thirty-six lesions were biopsy confirmed malignant, with 5 in situ and 31 invasive malignancies; the remaining 18 lesions were benign. In comparison with non-malignant lesions, malignant lesions were associated with an increase in clinically appreciable vascular features after injection of lidocaine/epinephrine, X-2 (1) = 21.600, p < 0.001. Further stratification into benign, in situ, and invasive lesions strengthened the association, X-2 (1) = 23.272, p < 0.001.ConclusionsCombination lidocaine/epinephrine has been shown to paradoxically increase the visibility of vessels seen in cutaneous malignancies. This is consistent with prior literature suggesting aberrant adrenergic signaling in neoangiogenic vessels.
  • No Thumbnail Available
    Item
    The role of ultraviolet-induced fluorescence dermatoscopy for the detection of multiple aggregated yellow-white globules in basal cell carcinoma
    (American Academy of Dermatology, Inc., 2024) Navarrete Dechent, Cristian Patricio; Pietkiewicz, Pawel; Astronave, Gisel; Marghoob, Nadeem G.; Dusza, Stephen W.; Lorenzoni Gaete, María Josefina; Boleira, Manuela; Cristopher, Michael; Valdivia Agüero, Rosario del Pilar; Bustos, Sergio; Jaimes, Natalia; Kurpis, María; Hidalgo Acuña, Leonel Esteban; Abarzúa Araya, Alvaro Rodrigo; Zoroquiain Velez, José Pablo; Uribe González, Pablo Francisco; Cárdenas de la Torre, Consuelo Paz; Droppelmann Droppelmann Katherine Ann; Marghoob, Ashfaq A.