Browsing by Author "Majerson Grinberg, Alejandro"
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- ItemBipolar or monopolar transurethral resection for benign prostatic hyperplasia?(2018) Inzunza, Gabriel; Rada G., Gabriel; Majerson Grinberg, Alejandro
- ItemBladder squamous cell carcinoma in a pregnant woman: case report and review of the literature(2021) Rojas, Pablo A.; González, Cristián; Méndez Olivieri, Gonzalo Patricio; Majerson Grinberg, Alejandro; San Francisco Reyes, Ignacio FelipeAbstract Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.
- ItemCirugía conservadora de riñón para tumores renales pequeños, papel de la radiofrecuencia(2009) Velasco, Alfredo; Castillo, Octavio; Vidal, Ivar; Sánchez-Salas, Rafael; Campos, Rodrigo; Cabello, Renato; Balbontín, Felipe; Majerson Grinberg, Alejandro; González Vicente, Gilberto BenjamínOBJECTIVES: Laparoscopically assisted radiofrequency is a minimally invasive nephron-sparing treatment option for renal tumors, mainly in patients with high comorbidity. We present the short-term results of our series patients treated with this novel technique. METHODS: Renal lesions smaller than 4 cm, suspicious of malignancy or metastasis on CT scan or MRI are candidates for radiofrequency. Under laparoscopic vision the tumor is identified, and percutaneous biopsy is performed. Depending on the size of the tumor, a number of punctures with the radiofrequency needle are performed with the aim to achieve tumor necrosis during at least one cycle of radiofrequency. Follow-up is performed with MRI in the first postoperative day and then after CT scan or MRI at 1, 3, 6 and 12 months. The persistent absence of contrast or vascular necrosis of the lesion is considered a satisfactory ablation without recurrence. RESULTS: 12 patients, two with metastasis and ten with primary lesions (mean age 60.8 years), with one or more lesions suspicious of malignancy underwent radiofrequency. Mean ASA was 2.4. 15 tumors were treated, with a mean diameter of 2.8 cm. An average of 2.5 punctures was performed with the radiofrequency needle. Biopsy results showed: one case of thyroid cancer metastasis, one case of melanoma metastasis, and 10 cases of renal cell carcinoma. Mean hospital stay was 25.8 hours. There were not short-term complications. Follow-up time was 8.8 months. Today there is no evidence of recurrence in imaging tests.ç CONCLUSIONS: Radiofrequency is effective eradicating small renal lesions, both primary and metastatic; it is especially useful in patients with high comorbidity. Despite the number of patients with adequate follow-up is not enough, the technology is promising. The approach under laparoscopic vision contributes to an effective biopsy, avoiding dissemination and enabling a more precise radiofrequency by direct vision control of tumor necrosis.
- ItemCirugía conservadora de riñón para tumores renales pequeños, papel de la radiofrecuencia(Palgrave Macmillan, 2009) Velasco, Alfredo; Castillo, Octavio; Vidal, Ivar; Sánchez-Salas, Rafael; Campos, Rodrigo; Cabello, Renato; Balbontín, Felipe; Majerson Grinberg, Alejandro; González Vicente, Gilberto BenjamínOBJECTIVES: Laparoscopically assisted radiofrequency is a minimally invasive nephron-sparing treatment option for renal tumors, mainly in patients with high comorbidity. We present the short-term results of our series patients treated with this novel technique. METHODS: Renal lesions smaller than 4 cm, suspicious of malignancy or metastasis on CT scan or MRI are candidates for radiofrequency. Under laparoscopic vision the tumor is identified, and percutaneous biopsy is performed. Depending on the size of the tumor, a number of punctures with the radiofrequency needle are performed with the aim to achieve tumor necrosis during at least one cycle of radiofrequency. Follow-up is performed with MRI in the first postoperative day and then after CT scan or MRI at 1, 3, 6 and 12 months. The persistent absence of contrast or vascular necrosis of the lesion is considered a satisfactory ablation without recurrence. RESULTS: 12 patients, two with metastasis and ten with primary lesions (mean age 60.8 years), with one or more lesions suspicious of malignancy underwent radiofrequency. Mean ASA was 2.4. 15 tumors were treated, with a mean diameter of 2.8 cm. An average of 2.5 punctures was performed with the radiofrequency needle. Biopsy results showed: one case of thyroid cancer metastasis, one case of melanoma metastasis, and 10 cases of renal cell carcinoma. Mean hospital stay was 25.8 hours. There were not short-term complications. Follow-up time was 8.8 months. Today there is no evidence of recurrence in imaging tests.ç CONCLUSIONS: Radiofrequency is effective eradicating small renal lesions, both primary and metastatic; it is especially useful in patients with high comorbidity. Despite the number of patients with adequate follow-up is not enough, the technology is promising. The approach under laparoscopic vision contributes to an effective biopsy, avoiding dissemination and enabling a more precise radiofrequency by direct vision control of tumor necrosis.
- ItemEarly ureteroscopic treatment in patients with urosepsis associated with ureteral calculi is a safe approach. A pilot study(2019) Astroza Eulufi, Gastón Maximiliano; Sarras, M.; Salvado, José A.; Majerson Grinberg, Alejandro; Neira, R.; Domínguez C., Javier
- ItemLabhardt's colpoperineocleisis : subjective results of an alternative treatment for genital prolapse in patients who are not sexually active-2-year follow-up(2014) Pizarro Berdichevsky, Javier Alejandro; Galleguillos Leyton, Gonzalo Ignacio; Cuevas Gallegos, Rodrigo; Blümel, Bernardita; Pattillo Garnham, Alejandro; González, Silvana; Majerson Grinberg, Alejandro; Padilla Pérez, Oslando; Cuello F., Mauricio; Ortiz Castro, Juan Andrés; Goldman, Howard B.
- ItemMismatch repair expression in testicular cancer predicts recurrence and survival(2008) Velasco Palma, Alfredo Alejandro; Corvalán Rodríguez, Alejandro; Wistuba, Ignacio I.; Riquelme, Erick; Chuaqui, Rodrigo; Majerson Grinberg, Alejandro; Leach, Fredrick S.We investigated mismatch repair (MMR) gene expression in testicular cancer as a molecular marker for clinical outcome (recurrence, response to chemotherapy and death) using protein expression and specific genetic alterations associated with the presence or absence of MMR activity. One hundred sixty-two cases of paraffin-embedded testis cancer specimens were subjected to immunohistochemical analysis using monoclonal antibody for MLH1 and MSH2 MMR proteins and genetic analysis using specific polymorphic markers. The degree of MMR immunoreactivity and genetic instability in the form of loss of heterozygosity (LOH) and/or microsatellite instability (MSI) were determined by comparing matched normal and tumor tissue. The degree of immunohistochemical staining for MMR expression was associated with a shorter time to tumor recurrence, resistance to chemotherapy and death. Furthermore, clinical relapse and cancer specific death was also associated with tumors exhibiting a high degree of MSI, p = 0.01 and 0.04, respectively. In contrast, LOH was not associated with recurrence, resistance to chemotherapy or death. Therefore, MMR expression defines testis cancers with distinct molecular properties and clinical behavior, such that tumors with decreased MMR immunostaining and/or increased frequency of MSI have a shorter time to recurrence and death despite chemotherapy. (c) 2007 Wiley-Liss, Inc.
- ItemPerfusión hipotérmica de máquina versus preservación en frío estático en el trasplante de riñón(2018) Dominguez, J.I.; De Amesti, M.; Majerson Grinberg, Alejandro