Browsing by Author "MacKerell, Alexander D., Jr."
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- ItemInhibition Requirements of the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT) Using Aminopiperidine Conjugates of glutamyl-Bile Acids(2009) Gonzalez, Pablo M.; Acharya, Chayan; MacKerell, Alexander D., Jr.; Polli, James E.Synthesize aminopiperidine conjugates of glutamyl-bile acids (glu-BAs) and develop a hASBT inhibition model using the conformationally sampled pharmacophore (CSP) approach.
- ItemPutative Irreversible Inhibitors of the Human Sodium-Dependent Bile Acid Transporter (hASBT; SLC10A2) Support the Role of Transmembrane Domain 7 in Substrate Binding/Translocation(2012) Gonzalez, Pablo M.; Hussainzada, Naissan; Swaan, Peter W.; MacKerell, Alexander D., Jr.; Polli, James E.To explore the involvement of transmembrane domain (TM) 7 of the human apical sodium-dependent bile acid transporter (hASBT) on bile acid (BA) binding/translocation, using two electrophilic BA derivatives as molecular probes.