Browsing by Author "MORENO, R"

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    INSPIRATORY MUSCLE DYSFUNCTION AND UNEXPLAINED DYSPNEA IN SYSTEMIC LUPUS-ERYTHEMATOSUS
    (1985) JACOBELLI, S; MORENO, R; MASSARDO, L; RIVERO, S; LISBOA, C
    The role of inspiratory muscle dysfunction in lung volume restriction and unexplained dyspnea was studied in 16 patients with systemic lupus erythematosus [SLE]. Maximal mouth inspiratory pressure (PIM) and maximal transdiaphragmatic pressure (Pdimax) were measured. Pdi and its components were determined during quiet breathing. No significant association was found between the activity of the disease, several serologic markers and the in spiratory muscle dysfunction. No specific anti-skeletal muscle antibody was found in these patients. Significant correlations were found between the degree of dyspnea and PIM (r = 0.69, P < 0.01) and Pdimax (r = -0.75, P < 0.001); however, dyspnea did not correlate with specific lung compliance. Vital capacity correlated significantly with the degree of dyspnea (r = -0.813, P < 0.001) and with Pdimax (r = 0.544, P < 0.05). No correlation was found between vital capacity and specific lung compliance. Inspiratory muscle dysfunction can be an important mechanism in the pathogenesis of the lung volume restriction and dyspnea in patients with SLE.
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    ORGANOMETALLIC CHELATING LIGANDS - SYNTHESIS OF A NEW ANIONIC TRIPOD LIKE LIGAND WITH AN N,N',O-DONOR SET - X-RAY CRYSTAL-STRUCTURE OF [(ETA(6)-C6ME6)RU(MU-P(O)(OME)2)(MU-PZ)2RE(CO)3] (ME=METHYL, PZ=PYRAZOLATE)
    (1994) SCOTTI, M; VALDERRAMA, M; MORENO, R; LOPEZ, R; BOYS, D
    The synthesis of the new anionic organometallic chelating ligand [(eta6-C6Me6)Ru{P(O)(OMe)2}(Pz)2]- = L-(Me = methyl, Pz = pyrazolate) is described. This ligand was isolated as its neutral sodium derivative NaL. approximately 0.7NaPF6, which is a new synthetic precursor for obtaining heterobimetallic complexes with phosphonate and pyrazolate groups acting as bridging ligands. The heterobimetallic compound LRe(CO)3 was obtained by reaction of ReBr(CO)5 with NaL. approximately 0.7NaPF6, in which the anionic complex L- is acting as an N,N',O-tripod donor ligand. The structure of the title complex was established by X-ray crystallography. The compound crystallizes as monoclinic, space group Cc (No. 9) with a=31.214(6), b=11.111(2), c=15.769(3) angstrom, beta=103.14(3)-degrees. The neutral complex has a binuclear structure with the (C6Me6)Ru and Re(CO)3 Moieties triply bridged by two pyrazolate groups and one phosphonate group. The synthesis of TlPz is also described.
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    WEEKLY CUIRASS VENTILATION IMPROVES BLOOD-GASES AND INSPIRATORY MUSCLE STRENGTH IN PATIENTS WITH CHRONIC AIR-FLOW LIMITATION AND HYPERCARBIA
    (1988) GUTIERREZ, M; BEROIZA, T; CONTRERAS, G; DIAZ, O; CRUZ, E; MORENO, R; LISBOA, C
    We studied the effects of an 8-h, once-a-week schedule of cuirass ventilation (CV) in 5 patients with advanced chronic air-flow limitation and chronic hypercarbia (PaCO2, 58.6 .+-. 10.1 mm Hg; mean .+-. SD). Repeated measurements of arterial blood gases, maximal inspiratory mouth pressure (Pimax), 12-min walking distance, and respiratory cycle were performed during a 1-mouth run-in period. Quality of life and transdiaphragmatic pressure were measured once. All patients completed the planned 4-month study. Four of them were ventilated for longer periods because CV could not be discontinued at the end of the study. PaCO2 showed a significant fall starting during the first month; PaO2 significantly increased from the second month, whereas Pimax significantly rose from the third month on. Maximal trnsdiaphragmatic pressure increased in the 2 patients with abnormal baseline values. The fall in PaCO2 was associated with an increase in tidal volume because of a longer inspiratory time. Significant improvements in quality of life and in the 12-min walking distance were observed. We conclude that weekly CV improves blood gases, inspiratory muscle strength, and clinical conditions of patients with chronic air-flow limitation and chronic hypercarbia, probably because of correction of chronic inspiratory muscle fatigue.