Browsing by Author "MARUSIC, ET"

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    PLASMA-ALDOSTERONE RESPONSE TO ANGIOTENSIN-11 AND KCL INFUSIONS IN HYPOPITUITARY PATIENTS
    (1980) LOPEZ, JM; RODRIGUEZ, JA; MARUSIC, ET
    The acute adrenal response to KCl and angiotensin II (A II) infusions was studied in hypopituitary patients and compared with normal subjects. The peripheral plasma levels of aldosterone (PAC), cortisol, K and plasma renin activity, were measured at 0900 h and after 60 and 120 min of infusion. All subjects were recumbent and under balance conditions, receiving a daily dietary intake of 180 mmol of Na and 80 mmol of K. Basal PAC in hypopituitary patients was not significantly different from that observed in the control group. Both normal and hypopituitary patients respond to A II infusion with significant increments. Under KCl stimulus the PAC response in hypopituitary patients was only observed when cortisol (20 mg) was given 2 h prior to the infusion. When cortisol replacement was omitted the response to KCl was not detected. These results suggest a permissive role of cortisol on glomerulosa response to K.