Browsing by Author "Luis Vukasovic, Jose"

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    Fine Particulate Air Pollution (PM2.5) Increases Emergency Hospital Admissions due to Decompensate Heart Failure
    (LIPPINCOTT WILLIAMS & WILKINS, 2009) Vera, Jeanette; Castro, Pablo; Cifuentes, Luis; Wellenius, Gregory; Verdejo, Hugo; Luis Vukasovic, Jose
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    Galectin-3 levels in patients hospitalized for decompensated heart failure
    (SOC MEDICA SANTIAGO, 2017) Rossel, Victor; Diaz Toro, Felipe; Verdejo, Hugo; Concepcion, Roberto; Sepulveda, Luis; Castro, Pablo; Luis Vukasovic, Jose; Bernales, Angie; Representacion Departmento Insufic
    Galectin-3 (Gal-3) is a mediator of myocardial fibrosis involved in cardiac remodeling and a potential new prognosis marker in heart failure (HF). Aim: To measure Gal-3 at the moment of discharge in patients hospitalized for HF and its association with different variables. Material and Methods: Patients hospitalized for decompensated HF from four hospitals between August 2014 and March 2015, were included. Demographic, clinical and laboratory variables were recorded at the time of admission. At discharge, a blood sample was withdrawn to measure Gal-3 and brain natriuretic propeptide (Pro-BNP). Patients were separated in two groups, according to the level of Gal-3 (using a cutoff value of 17.8 ng/mL), comparing clinical and laboratory values between groups. Results: We included 52 patients with HF aged 70 17 years (42% females). Functional capacity was III-IV in 46% of patients and the ejection fraction was 34.9 13.4%. Pro-BNP values at discharge were 5,323 8,665 pg/mL. Gal-3 values were 23.8 16.6 ng/mL. Sixty percent of patients had values over 17.8 ng/mL. Those with elevated Gal-3 levels were older (75 16 and 62 15 years, respectively, p = 0.025) and were hypertensive in a higher proportion (90.5% and 57.1% respectively, p = 0.021). Conclusions: In patients hospitalized for HF, Gal-3 levels are higher in older and hypertensive subjects.