Browsing by Author "Losada, H."

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    Gallbladder polyps : Correlation of size and clinicopathologic characteristics based on updated definitions
    (2020) Taskin, O. C.; Basturk, O.; Reid, M. D.; Dursun, N.; Bagci, P.; Saka, B.; Balci, S.; Memis, B.; Roa Strauch, Juan Carlos Enrique; Bellolio, E.; Araya, J. C.; Tapia, O.; Losada, H.; Sarmiento, J.; Jang, K. T.; Jang, J. Y.; Pehlivanoglu, B.; Erkan, M.; Adsay, V.
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    Laparoscopic Liver Resection: A South American Experience with 2887 Cases
    (2020) Pekolj, J.; Claria Sanchez, R.; Salceda, J.; Maurette, R. J.; Schelotto, P. B.; Pierini, L.; Canepa, E.; Moro, M.; Stork, G.; Resio, N.; Neffa, J.; Mc Cormack, L.; Quinonez, E.; Raffin, G.; Obeide, L.; Fernandez, D.; Pfaffen, G.; Salas, C.; Linzey, M.; Schmidt, G.; Ruiz, S.; Alvarez, F.; Buffaliza, J.; Maroni, R.; Campi, O.; Bertona, C.; de Santibanes, M.; Mazza, O.; Belotto de Oliveira, M.; Diniz, A. L.; Enne de Oliveira, M.; Machado, M. A.; Kalil, A. N.; Pinto, R. D.; Rezende, A. P.; Ramos, E. J. B.; Talvane T. Oliveira, A.; Torres, O. J. M.; Jarufe Cassis, N.; Buckel, E.; Quevedo Torres, R.; Chapochnick, J.; Sanhueza Garcia, M.; Munoz, C.; Castro, G.; Losada, H.; Vergara Suarez, F.; Guevara, O.; Davila, D.; Palacios, O.; Jimenez, A.; Poggi, L.; Torres, V.; Fonseca, G. M.; Kruger, J. A. P.; Coelho, F. F.; Russo, L.; Herman, P.
    Background Laparoscopic liver resections (LLR) have been increasingly performed in recent years. Most of the available evidence, however, comes from specialized centers in Asia, Europe and USA. Data from South America are limited and based on single-center experiences. To date, no multicenter studies evaluated the results of LLR in South America. The aim of this study was to evaluate the experience and results with LLR in South American centers. Methods From February to November 2019, a survey about LLR was conducted in 61 hepatobiliary centers in South America, composed by 20 questions concerning demographic characteristics, surgical data, and perioperative results. Results Fifty-one (83.6%) centers from seven different countries answered the survey. A total of 2887 LLR were performed, as follows: Argentina (928), Brazil (1326), Chile (322), Colombia (210), Paraguay (9), Peru (75), and Uruguay (8). The first program began in 1997; however, the majority (60.7%) started after 2010. The percentage of LLR over open resections was 28.4% (4.4-84%). Of the total, 76.5% were minor hepatectomies and 23.5% major, including 266 right hepatectomies and 343 left hepatectomies. The conversion rate was 9.7%, overall morbidity 13%, and mortality 0.7%. Conclusions This is the largest study assessing the dissemination and results of LLR in South America. It showed an increasing number of centers performing LLR with the promising perioperative results, aligned with other worldwide excellence centers.
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    Mendelian Randomization Analysis of the Relationship Between Native American Ancestry and Gallbladder Cancer Risk
    (2022) Zollner, L.; Boekstegers, F.; Ponce, C.B.; Scherer, D.; Marcelain, K.; Gárate-Calderón, V.; Waldenberger, M.; Morales, E.; Rojas, A.; Munoz, C.; Müller, B.; Retamales, J.; de Toro, G.; Kortmann, A.V.; Barajas, O.; Rivera, M.T.; Cortés, A.; Loader, D.; Saavedra, J.; Gutiérrez, L.; Ortega, A.; Bertrán, M.E.; Bartolotti, L.; Gabler, F.; Campos, M.; Alvarado, J.; Moisán, F.; Spencer, L.; Nervi Nattero, Bruno; Carvajal, D.; Losada, H.; Almau, M.; Fernández, P.; Olloquequi, J.; Carter, A.R.; Miquel, Juan Francisco; Bustos, B.I.; Guajardo, M.F.; Gonzalez-Jose, R.; Bortolini, M.C.; Acuña-Alonzo, V.; Gallo, C.; Linares, A.R.; Rothhammer, F.; Bermejo, J.L.
    Background A strong association between the proportion of Native American ancestry and the risk of gallbladder cancer (GBC) has been reported in observational studies. Chileans show the highest incidence of GBC worldwide, and the Mapuche are the largest Native American people in Chile. We set out to investigate the causal association between Native American Mapuche ancestry and GBC risk, and the possible mediating effects of gallstone disease and body mass index (BMI) on this association. Methods Markers of Mapuche ancestry were selected based on the informativeness for assignment measure and then used as instrumental variables in two-sample mendelian randomization (MR) analyses and complementary sensitivity analyses. Result We found evidence of a causal effect of Mapuche ancestry on GBC risk (inverse variance-weighted (IVW) risk increase of 0.8% for every 1% increase in Mapuche ancestry proportion, 95% CI 0.4% to 1.2%, p = 6.6×10-5). Mapuche ancestry was also causally linked to gallstone disease (IVW risk increase of 3.6% per 1% increase in Mapuche proportion, 95% CI 3.1% to 4.0%, p = 1.0×10-59), suggesting a mediating effect of gallstones in the relationship between Mapuche ancestry and GBC. In contrast, the proportion of Mapuche ancestry showed a negative causal effect on BMI (IVW estimate -0.006 kg/m2 per 1% increase in Mapuche proportion, 95% CI -0.009 to -0.003, p = 4.4×10-5). Conclusions The results presented here may have significant implications for GBC prevention and are important for future admixture mapping studies. Given that the association between Mapuche ancestry and GBC risk previously noted in observational studies appears to be causal, primary and secondary prevention strategies that take into account the individual proportion of Mapuche ancestry could be particularly efficient.
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    Mural intracholecystic neoplasms arising in adenomyomatous nodules of the gallbladder an analysis of 19 examples of a clinicopathologically distinct entity
    (2020) Rowan, D. J.; Pehlivanoglu, B.; Memis, B.; Bagci, P.; Erbarut, I.; Dursun, N.; Jang, K. T.; Sarmiento, J.; Mucientes, F.; Roa Strauch, Juan Carlos Enrique; Cheng, J. D.; Araya, J. C; Bellolio, E.; Losada, H.; Jang, J. Y.; Koshiol, J.; Reid, M. D.; Basturk, O.; Adsay, V.
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    Non-neoplastic Polyps of the Gallbladder A Clinicopathologic Analysis of 447 Cases
    (2020) Taskin, O. C.; Bellolio, E.; Dursun, N.; Seven, I. E.; Roa Strauch, Juan Carlos Enrique; Araya, J. C.; Villaseca, M.; Tapia, O.; Vance, C.; Saka, B.; Balci, S.; Bagci, P.; Losada, H.; Sarmiento, J.; Memis, B.; Pehlivanoğlu, B.; Basturk, O.; Reid, M. D.; Koshiol, J.; Cheng, J. D.; Kapran, Y.; Adsay, V.
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    Sarcomatoid carcinomas of the gallbladder: clinicopathologic characteristics
    (2019) Taskin, O. C.; Akkas, G.; Memis, B.; Seven, I. E.; Basturk, O.; Jang, K. T.; Roa Strauch, Juan Carlos Enrique; Araya, J. C.; Bellolio, E.; Losada, H.; Sarmiento, J.; Balci, S.; Pehlivanoglu, B.; Reid, M. D.; Koshiol, J.; Adsay, V.