Browsing by Author "Legues, ME"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- ItemDiscordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia(1996) Campbell, M; Cabrera, ME; Legues, ME; Ridge, S; Greaves, MWe report the different presentation features and clinical outcome between two identical infant twins with acute lymphoblastic leukaemia with a shared clonal disease and MLL gene rearrangement. One twin relapsed and died, but the other is in complete remission >4 years after diagnosis. These data, and Similar observations on other twin infants with leukaemia, suggest that despite a common clonal in utero, post-natally these leukaemias can evolve independently, at different rates, in the twinned individuals, and that the usually fatal leukaemia associated with t(4;11) MLL gene rearrangement can be effectively treated when the leukaemic burden is small.
- ItemSelective engraftment of the granulocyte compartment after allogeneic bone marrow transplantation in a patient with severe aplastic anemia(1996) Barriga, FJ; Legues, ME; Bertin, PPurpose: We present a patient with severe aplastic anemia who had partial engraftment with full chimerism after allogeneic bone marrow transplantation from an HLA identical sibling.