Browsing by Author "Landmesser, Ulf"

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    Clinical quantitative coronary artery stenosis and coronary atherosclerosis imaging: a Consensus Statement from the Quantitative Cardiovascular Imaging Study Group
    (2023) Mezquita, Aldo J. Vazquez; Biavati, Federico; Falk, Volkmar; Alkadhi, Hatem; Hajhosseiny, Reza; Maurovich-Horvat, Pal; Manka, Robert; Kozerke, Sebastian; Stuber, Matthias; Derlin, Thorsten; Channon, Keith M.; Isgum, Ivana; Coenen, Adriaan; Foellmer, Bernhard; Dey, Damini; Volleberg, Rick H. J. A.; Meinel, Felix G.; Dweck, Marc R.; Piek, Jan J.; van de Hoef, Tim; Landmesser, Ulf; Guagliumi, Giulio; Giannopoulos, Andreas A.; Botnar, Rene M.; Khamis, Ramzi; Williams, Michelle C.; Newby, David E.; Dewey, Marc
    In this Consensus Statement, Dewey and the other members of the Quantitative Cardiovascular Imaging Study Group provide clinical consensus recommendations on the optimal use of different imaging techniques in various patient populations to detect and assess coronary artery stenosis and atherosclerosis.
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    Noninvasive Imaging of Endothelial Damage in Patients With Different HbA(1c) Levels : A Proof-of-Concept Study
    (2019) Engel, Leif-Christopher; Landmesser, Ulf; Goehler, Alexander; Gigengack, Kevin; Wurster, Thomas-Heinrich; Manes, Costantina; Girke, Georg; Jaguszewski, Milosz; Skurk, Carsten; Botnar, René Michael; Leistner, David M.; Lauten, Alexander; Schuster, Andreas; Noutsias, Michel; Hamm, Bernd; Bigalke, Boris; Makowski, Marcus R.
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    Simultaneous [18F]fluoride and gadobutrol enhanced coronary positron emission tomography/magnetic resonance imaging for in vivo plaque characterization
    (Oxford University Press, 2022) Wurster, Thomas H.; Landmesser, Ulf; Abdelwahed, Youssef S.; Skurk, Carsten; Morguet, Andreas; Leistner, David M.; Froehlich, Georg; Haghikia, Arash; Engel, Leif Christopher; Botnar, René Michael; Schuster, Andreas; Noutsias, Michel; Schulze, Daniel; Hamm, Bernd; Furth, Christian; Brenner, Winfried; Bigalke, Boris; Makowski, Marcus R.
    Aims F-18-sodium fluoride ([18F]fluoride) and gadobutrol are promising probes for positron emission tomography (PET) and magnetic resonance imaging (MRI) characterizing coronary artery disease (CAD) activity. Unlike [18F]fluoride-PET/computed tomography (CT), the potential of PET/MR using [18F]fluoride and gadobutrol simultaneously, has so far not been evaluated. This study assessed feasibility and diagnostic potential of [18F]fluoride and gadobutrol enhanced dual-probe PET/MR in patients with CAD. Methods and results Twenty-one patients (age, 66.7 +/- 6.7 years) with CAD scheduled for invasive coronary angiography (XCA) underwent simultaneous [18F]fluoride (mean activity/effective dose: 157.2 +/- 29.7 MBq/3.77 +/- 0.72 mSv) and gadobutrol enhanced PET/MR on an integrated PET/MRI (3 T) scanner. Optical coherence tomography (OCT) was used as reference. Target-to-background ratio (TBR, [18F]fluoride-PET) and contrast-to-noise ratio (CNR) values (MRI, gadobutrol) were calculated for each coronary segment. Previously suggested PET/CT-TBR thresholds for adverse coronary events were evaluated. High-risk plaques, i.e. calcified and non-calcified thin-cap fibroatheromas (TCFAs) were predominantly located in segments with a TBR >1.28 (P = 0.012). Plaques containing a lipid core on OCT, were more frequently detected in segments with a TBR >1.25 (P < 0.001). TBR values significantly correlated with maximum calcification thickness (P = 0.009), while fibrous cap thickness was significantly less in segments with a TBR >1.28 (P = 0.044). Above a TBR threshold of >1.28, CNR values significantly correlated with the presence of calcified TCFAs (P = 0.032). Conclusion Simultaneous [18F]fluoride and gadobutrol dual-probe PET/MRI is feasible in clinical practice and may facilitate the identification of high-risk patients. The combination of coronary MR-derived CNR values post gadobutrol and [18F]fluoride based TBR values may improve identification of high-risk plaque features.