Browsing by Author "Lagos, Carlos"

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    A Deletion Encompassing Exon 2 of the ALS Gene: Analysis of a Patient with ALS Deficiency and His Family
    (KARGER, 2018) Poggi, Helena; Arancibia, Monica; Benavides, Felipe; Lagos, Carlos; Vecchiola, Andrea; Dominguez Menendez, Gonzalo; Martinez Aguayo, Alejandro
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    Design, Synthesis, Binding and Docking-Based 3D-QSAR Studies of 2-Pyridylbenzimidazoles—A New Family of High Affinity CB1 Cannabinoid Ligands
    (2013) Espinosa Bustos, Christian; Iturriaga Vásquez, Patricio; Lagos, Carlos; Mella Raipán, Jaime; Pessoa Mahana, Carlos David; Pessoa Mahana, Hernán; Recabarren Gajardo, Gonzalo Iván; Romero Parra, Javier Hernán
    A series of novel 2-pyridylbenzimidazole derivatives was rationally designed and synthesized based on our previous studies on benzimidazole 14, a CB1 agonist used as a template for optimization. In the present series, 21 compounds displayed high affinitie
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    Dynamic Optimization for Airline Maintenance Operations
    (INFORMS, 2020) Lagos, Carlos; Delgado, Felipe; Klapp, Mathias A.
    The occurrence of unexpected aircraft maintenance tasks can produce expensive changes in an airline's operation. When it comes to critical tasks, it might even cancel programmed flights. Despite this, the challenge of scheduling aircraft maintenance operations under uncertainty has received limited attention in the scientific literature. We study a dynamic airline maintenance scheduling problem, which daily decides the set of aircraft to maintain and the set of pending tasks to execute in each aircraft. The objective is to minimize the expected costs of expired maintenance tasks over the operating horizon. To increase flexibility and reduce costs, we integrate maintenance scheduling with tail assignment decisions. We formulate our problem as a Markov decision process and design dynamic policies based on approximate dynamic programming, including value function approximation, rolling horizon techniques, and a hybrid policy between the latter two that deliversthebest results. In a casestudy based on LATAM airline, we show the value of dynamic optimization by testing our best policies against a simple airline decision rule and a deterministic relaxation with perfect future information. We suggest to schedule tasks requiring less resources first to increase utilization of residual maintenance capacity. Finally, we observe strong economies of scale when sharing maintenance resources between multiple airlines.
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    Microwave Assisted Synthesis of Novel Six-Membered 4-C, 4-O and 4-S Lactams Derivatives: Characterization and in vitro Biological Evaluation of Cytotoxicity and Anticoagulant Activity
    (2017) Núñez Navarro, Nicolás Ernesto; Segovia Bonnemaison, Gerardine Francoise; Burgos, Renato; Lagos, Carlos; Fuentes, Nataly; Faundez, Mario; Zacconi, Flavia C. M.
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    Reporte de caso de feocromocitoma bilateral asociado a mutación del gen TMEM127. Primer caso chileno
    (2022) Delgado García, José Fröbel; Perez E., María Javiera; Delgado, Dasha; Lagos, Carlos; Baudrand Biggs, René; Uslar N., Thomas
    Up to 40% of Pheochromocytoma/paraganglioma syndromes are associated with germline mutations. Therefore, they are considered familial and heritable. We report a 65 year old woman with hypertension, bilateral adrenal nodules found in the CT scan and elevated urinary metanephrines. Her genetic testing showed a c.117_120delGTCT TMEM127 gene mutation. She was subjected to a laparoscopic bilateral adrenal excision. After five years of follow up, no recurrence of the disease has been recorded.