Browsing by Author "Labarca, Gonzalo"

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    Aplicaciones torácicas del ultrasonido
    (2016) Fernández Bussy, S.; Labarca, Gonzalo; Lanza, M.; Folch, E.; Majid, A.
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    Chronic eosinophilic pneumonia. Report of one case
    (SOC MEDICA SANTIAGO, 2016) Fernandez Bussy, Sebastian; Campos, Felipe; Ogueta, Isabel; Labarca, Gonzalo; Cabello, Hernan
    Chronic eosinophilic pneumonia (CEP) is uncommon and predominantly seen in women. More than 6% of eosinophils in peripheral blood and more than 25% in bronchoalveolar lavage are diagnostic criteria. Secondary causes of hypereosinophilic pneumonia must be ruled out. We report a 72-year-old non-smoker man presenting in the emergency room with a history of cough, fever, and moderate dyspnea. He was not taking any medication. A chest-X ray showed a left lower lobe (LLL) consolidation, and was started on broad-spectrum antibiotics with a presumptive diagnosis of pneumonia. There was no improvement after therapy. A chest CT scan showed increased LLL consolidation and new left upper lobe ground glass opacities as well as a moderate left pleural effusion. Flexible bronchoscopy was performed and bronchoalveolar lavage showed 95% eosinophils, and had negative cultures. No parasites were identified. Transbronchial biopsies demonstrated eosinophil accumulation in alveoli and interstitium and pleural fluid was composed by 85% eosinophils. With the diagnosis of CEP, systemic corticosteroids were used with favorable clinical and radiological response.
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    Clinical and pulmonary function analysis in long-COVID revealed that long-term pulmonary dysfunction is associated with vascular inflammation pathways and metabolic syndrome
    (FRONTIERS MEDIA SA, 2023) Sanhueza, Sergio; Vidal, Mabel A.; Hernandez, Mauricio A.; Henriquez-Beltran, Mario E.; Cabrera, Camilo; Quiroga, Romina; Antilef, Barbara E.; Aguilar, Kevin P.; Castillo, Daniela A.; Llerena, Faryd J.; Figueroa, Marco Fraga; Nazal, Mauricio; Castro, Eritson; Lagos, Paola; Moreno, Alexa; Lastra, Jaime J.; Gajardo, Jorge; Garces, Pamela; Riffo, Benilde; Buchert, Jorge; Sanhueza, Rocio; Ormazaba, Valeska; Saldivia, Pablo; Vargas, Cristian; Nourdin, Guillermo; Koch, Elard; Zuniga, Felipe A.; Lamperti, Liliana; Bustos, Paula; Guzman-Gutierrez, Enrique; Tapia, Claudio A.; Ferrada, Luciano; Cerda, Gustavo; Woehlbier, Ute; Riquelme, Marcelo; Yuseff, Maria Isabel; Ramirez, Braulio A. Munoz; Lombardi, Giovanna; De Gonzalo-Calvo, David; Salomon, Carlos; Verdugo, Ricardo A.; Quinones, Luis A.; Colombo, Alicia; Barria, Maria I.; Labarca, Gonzalo; Nova-Lamperti, Estefania
    Introduction: Long-term pulmonary dysfunction (L-TPD) is one of the most critical manifestations of long-COVID. This lung affection has been associated with disease severity during the acute phase and the presence of previous comorbidities, however, the clinical manifestations, the concomitant consequences and the molecular pathways supporting this clinical condition remain unknown. The aim of this study was to identify and characterize L-TPD in patients with long-COVID and elucidate the main pathways and long-term consequences attributed to this condition by analyzing clinical parameters and functional tests supported by machine learning and serum proteome profiling. Methods: Patients with L-TPD were classified according to the results of their computer-tomography (CT) scan and diffusing capacity of the lungs for carbon monoxide adjusted for hemoglobin (DLCOc) tests at 4 and 12-months post-infection. Results: Regarding the acute phase, our data showed that L-TPD was favored in elderly patients with hypertension or insulin resistance, supported by pathways associated with vascular inflammation and chemotaxis of phagocytes, according to computer proteomics. Then, at 4-months post-infection, clinical and functional tests revealed that L-TPD patients exhibited a restrictive lung condition, impaired aerobic capacity and reduced muscular strength. At this time point, high circulating levels of platelets and CXCL9, and an inhibited FCgamma-receptor-mediated-phagocytosis due to reduced Fc gamma RIII (CD16) expression in CD14+ monocytes was observed in patients with L-TPD. Finally, 1-year post infection, patients with L-TPD worsened metabolic syndrome and augmented body mass index in comparison with other patient groups. Discussion: Overall, our data demonstrated that CT scan and DLCOc identified patients with L-TPD after COVID-19. This condition was associated with vascular inflammation and impair phagocytosis of virus-antibody immune complexes by reduced Fc gamma RIII expression. In addition, we conclude that COVID-19 survivors required a personalized follow-up and adequate intervention to reduce long-term sequelae and the appearance of further metabolic diseases.
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    Concomitant tracheal and subcutaneous glomus tumor : case report and review of the literature
    (2015) Fernandez-Bussy, Sebastian; Labarca, Gonzalo; Rodriguez, Macarena; Mehta, Hiren J.; Jantz, Michael
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    CPAP in patients with obstructive sleep apnea and type 2 diabetes mellitus: Systematic review and meta-analysis
    (2018) Labarca, Gonzalo; Reyes, Tomas; Jorquera Arévalo, Jorge Antonio; Dreyse, Jorge; Drake, Lauren
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    Dementia, gait disturbance, and urinary incontinence in a patient with pulmonary sarcoidosis
    (2016) Labarca, Gonzalo; Ramírez Corsi, Romina Victoria; Monsalve, Ximena; Mira-Avendaño, Isabel
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    Diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal staging in lung cancer
    (2015) Fernandez Bussy, Sebastián; Labarca, Gonzalo; Canals, Sofia; Caviedes, Iván; Folch, Erik; Majid, Adnan
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    Differences between manual and automatic analysis in determining the severity of obstructive sleep apnea using home sleep apnea testing
    (2018) Labarca, Gonzalo; Dreyse, Jorge; Salas, Constanza; Contreras, Andrea; Nazar, Gonzalo; Gaete, Maria I.; Jorquera Arévalo, Jorge Antonio
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    Endobronchial Involvement in Idiopathic Hypereosinophilic Syndrome
    (2015) Fernandez Bussy, Sebastian; Antunez, Miguel; Pires, Yumay; Labarca, Gonzalo
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    Endobronchial ultrasound and fine needle aspiration for central airway lesions
    (2016) Fernandez, S.; Labarca, Gonzalo; Caviedes, I.; Folch, E.; Majid, A
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    ¿Es efectivo el nintedanib para la fibrosis pulmonar idiopática?
    (2017) Jeldres, Alejandro; Labarca, Gonzalo
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    Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review
    (2024) Neshat, Seyed Sina; Heidari, Afshin; Henriquez-Beltran, Mario; Patel, Kripa; Colaco, Brendon; Arunthari, Vichaya; Mateus, Alejandra Yu Lee; Cheung, Joseph; Labarca, Gonzalo
    Obstructive sleep apnea (OSA) is associated with excessive daytime sleepiness (EDS). Pharmacotherapy offers a potential treatment approach for EDS in OSA patients. This systematic review and meta-analysis aimed to assess the efficacy and safety of pharmacological interventions for alleviating EDS in patients with OSA. Following PRISMA guidelines, we included randomized controlled trials investigating pharmacological treatments for EDS in adult OSA until August 2023. We conducted meta-analysis, subgroup, and meta-regression analyses using a random effects model. Finally, a network meta-analysis synthesized direct and indirect evidence, followed by a comprehensive safety analysis. We included 32 articles in the meta-analysis (n = 3357). Pharmacotherapy showed a significant improvement in the Epworth Sleepiness Scale (ESS) score (Mean Difference (MD) -2.73, (95 % Confidence Interval (CI) [-3.25, -2.20], p < 0.01) and Maintenance of Wakefulness Test (MWT) score (MD 6.00 (95 % CI [2.66, 9.33] p < 0.01). Solriamfetol, followed by Pitolisant and modafinil, exhibited the greatest ESS reduction, while Danavorexton, followed by Solriamfetol and MK-7288, had the strongest impact on MWT. MK-7288 had the most total adverse events (AEs), followed by Danavorexton and armodafinil. Pharmacological Interventions significantly alleviate EDS in OSA patients but with heterogeneity across medications. Treatment decisions should involve a personalized assessment of patient factors and desired outcomes.
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    Minimally Invasive Methods for Staging in Lung Cancer : Systematic Review and Meta-Analysis
    (2016) Labarca, Gonzalo; Aravena León, Carlos Andrés; Ortega, Francisco; Arenas, Alex; Majid, Adnan; Folch, Erik; Mehta, Hiren J.; Jantz, Michael A.; Fernandez Bussy, Sebastian
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    Physiologic Consequences of Upper Airway Obstruction in Sleep Apnea
    (2024) Azarbarzin, Ali; Labarca, Gonzalo; Kwon, Younghoon; Wellman, Andrew
    OSA is diagnosed and managed by a metric called the apnea-hypopnea index (AHI). The AHI quantifies the number of respiratory events (apnea or hypopnea), disregarding important information on the characteristics and physiologic consequences of respiratory events, including degrees of ventilatory deficit and associated hypoxemia, cardiac autonomic response, and cortical activity. The oversimplification of the disorder by the AHI is considered one of the reasons for divergent findings on the associations of OSA and cardiovascular disease (CVD) in observational and randomized controlled trial studies. Prospective observational cohort studies have demonstrated strong associations of OSA with several cardiovascular diseases, and randomized controlled trials of CPAP intervention have not been able to detect a benefit of CPAP to reduce the risk of CVD. Over the last several years, novel methodologies have been proposed to better quantify the magnitude of OSA-related breathing disturbance and its physiologic consequences. As a result, stronger associations with cardiovascular and neurocognitive outcomes have been observed. In this review, we focus on the methods that capture polysomnographic heterogeneity of OSA. CHEST 2024; 166(5):1209-1217
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    Pirfenidone for Idiopathic Pulmonary Fibrosis : A Systematic Review and Meta-Analysis
    (2015) Aravena León, Carlos Andrés; Labarca, Gonzalo; Venegas Garrido, Carmen Paz; Arenas, Alex; Rada G., Gabriel
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    Rendimiento diagnóstico de la broncoscopia con biopsia transbronquial en el estudio de lesiones sugerentes de cáncer pulmonar
    (2015) Fernández Bussy, Sebastián; Labarca, Gonzalo; Canals, Sofía; Zagollin, Mónica
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    Takayasu's arteritis and secondary membranous nephropathy: an exceptional association
    (2021) Enos, Daniel; Labarca, Gonzalo; Hernandez, Mariel; Mendez, Gonzalo P.
    The association between Takayasu's arteritis and membranous nephropathy is uncommon. We present the case of a 46-year-old man with Takayasu's arteritis treated over 10 years by a multidisciplinary medical team. He had an atrophic left kidney due to arterial stenosis, with a basal creatinine of 1.59 mg/dL (140.55 mu mol/l). Three years ago, he presented with full nephrotic syndrome, uncontrolled blood pressure, creatinine increases to 4.5 mg/dL (basal: 1.59 mg/dL), severe hypoalbuminaemia (1.4 g/dL) and albuminuria of 24.6 g per day. He underwent percutaneous biopsy of the right kidney that showed membranous nephropathy with negative PLA2R1 and positive IgG 1, 3 and 4 subclasses. After therapy with oral prednisone and cyclophosphamide, the patient's kidney function improved, without recurrence of disease after 3 years of follow-up. Here, we present this extremely uncommon association of Takayasu's arteritis and membranous nephropathy.
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    The boundaries of mild chronic obstructive pulmonary disease (COPD): design of the searching clinical COPD onset (SOON) study
    (2017) Labarca, Gonzalo; Bustamante, Andrea; Valdivia Cabrera, Gonzalo; Díaz Montero, Rodrigo Aquiles; Huete, Isidro; Mac Nab, Paul; Mendoza, Laura; Leppe, Jaime; Lisboa Basualto, Carmen; Saldías Peñafiel, Fernando; Díaz, Orlando