Browsing by Author "Kramer, Susanne"

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    Epidemiology of epidermolysis bullosa in Chile
    (2024) Palisson, Francis; Yubero, Maria Joao; Lecaros, Cristobal; Kramer, Susanne; Fuentes, Constanza; Morande, Pilar; Noya, Belkis; Cofre, Glenda; Castillo, Jimena; Acevedo, Francisco; Burattini, Natalia; Munoz, Antonella; Klausseger, Alfred; Fuentes, Ignacia
    In this manuscript we are presenting the first National Epidermolysis Bullosa Epidemiology study done in South America. Our manuscript describes not only population-level estimates, such as incidence, prevalence and mortality of EB, but also genetic data that are unique to this underrepresented population. We report new data about this rare disease showing comparable life expectancy to wealthier nations, demonstrating the value of specialized EB care centres.
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    Replenishment of type VII collagen and re-epithelialization of chronically ulcerated skin after intradermal administration of allogeneic mesenchymal stromal cells in two patients with recessive dystrophic epidermolysis bullosa
    (INFORMA HEALTHCARE, 2010) Conget, Paulette; Rodriguez, Fernando; Kramer, Susanne; Allers, Carolina; Simon, Valeska; Palisson, Francis; Gonzalez, Sergio; Yubero, Maria J.
    In animal models it has been shown that mesenchymal stromal cells (MSC) contribute to skin regeneration and accelerate wound healing. We evaluated whether allogeneic MSC administration resulted in an improvement in the skin of two patients with recessive dystrophic epidermolysis bullosa (RDEB; OMIM 226600). Patients had absent type VII collagen immunohistofluorescence and since birth had suffered severe blistering and wounds that heal with scarring. Vehicle or 0.5x10