Browsing by Author "Koriyama, C."

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    Determinants of Epstein-Barr virus-positive gastric cancer: an international pooled analysis
    (2011) Camargo, M. C.; Murphy, G.; Koriyama, C.; Pfeiffer, R. M.; Kim, W. H.; Herrera-Goepfert, R.; Corvalan, A. H.; Carrascal, E.; Abdirad, A.; Anwar, M.; Hao, Z.; Kattoor, J.; Yoshiwara-Wakabayashi, E.; Eizuru, Y.; Rabkin, C. S.; Akiba, S.
    BACKGROUND: Meta-analyses of the published literature indicate that about 9% of gastric cancers contain Epstein-Barr virus (EBV), with consistent and significant differences by sex and anatomic subsite. This study aimed to identify additional determinants of EBV positivity and their joint effects.
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    Human papillomavirus-16 is integrated in lung carcinomas: a study in Chile
    (2007) Aguayo, F.; Castillo, A.; Koriyama, C.; Higashi, M.; Itoh, T.; Capetillo, M.; Shuyama, K.; Corvalán R., Alejandro; Eizuru, Y.; Akiba, S.
    The human papillomavirus (HPV) was detected in 20 (29%) out of 69 lung carcinomas (LCs) in Chile, by PCR and Southern blot, and was more frequently detected in squamous cell carcinoma (SQC) than in adenocarcinomas (46 vs 9%, P = 0.001). HPV-16, positive in 11 cases, was the most frequently detected HPV genotype determined by DNA sequencing. HPV-16 E2/E6 ratio, estimated from real-time PCR analysis, was much lower than the unity, suggesting that at least a partial HPV-16 genome was integrated in all but one HPV-16-positive SQCs. The remaining one case was suspected to have only episomal HPV-16. Although the viral load was low in most of the LCs, a case showed the HPV-16 copy number as high as 8479 per nanogram DNA, which was even a few times higher than the minimum viral load of seven cervical carcinomas (observed viral load: 3356 - 609 392 per nanogram DNA). The expression of the HPV-16/18 E6 protein was found in only two HPV-16-positive SQCs (13%) but not in the case with the highest viral load. Although the viral load was in general very low and HPV E6 expression is none or weak, further studies seem warranted to examine aetiological involvement of high-risk HPV in lung carcinogenesis.
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    Nasal natural killer/T-cell lymphoma and its association with type "i"/Xhol loss strain Epstein-Barr virus in Chile
    (B M J PUBLISHING GROUP, 2007) Cabrera, M. E.; Eizuru, Y.; Itoh, T.; Koriyama, C.; Tashiro, Y.; Ding, S.; Rey, S.; Akiba, S.; Corvalan, A.
    Background: Nasal T/natural killer (NK)-cell lymphoma is an aggressive type of non-Hodking's lymphoma associated with Epstein-Barr virus (EBV) and striking geographical variations worldwide.