Browsing by Author "Kleeman, CR"

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    Phosphate depletion in the rat: Effect of bisphosphonates and the calcemic response to PTH
    (1999) Jara, A; Lee, E; Stauber, D; Moatamed, F; Felsenfeld, AJ; Kleeman, CR
    Background. The removal of phosphate from the diet of the growing rat rapidly produces hypercalcemia, hypophosphatemia, hypercalciuria, and hypophosphaturia. Increased calcium efflux from bone has been shown to be the important cause of the hypercalcemia and hypercalciuria. It has been proposed that the increased calcium efflux from bone is osteoclast mediated. Because bisphosphonates have been shown to inhibit osteoclast-mediated bone resorption, this study was performed to determine whether bisphosphonate-induced inhibition of osteoclast function changed the biochemical and bone effects induced by phosphate depletion.