Browsing by Author "Kaufmann, Jan O."
Now showing 1 - 3 of 3
Results Per Page
Sort Options
- ItemADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries(2022) Kaufmann, Jan O.; Brangsch, Julia; Kader, Avan; Saatz, Jessica; Mangarova, Dilyana B.; Zacharias, Martin; Kempf, Wolfgang E.; Schwaar, Timm; Ponader, Marco; Adams, Lisa C.; Moeckel, Jana; Botnar, Rene M.; Taupitz, Matthias; Maegdefessel, Lars; Traub, Heike; Hamm, Bernd; Weller, Michael G.; Makowski, Marcus R.New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo prediction of aneurysm and rupture.
- ItemAssessment of Albumin ECM Accumulation and Inflammation as Novel In Vivo Diagnostic Targets for Multi-Target MR Imaging(2021) Möckel, Jana; Brangsch, Julia; Reimann, Carolin; Kaufmann, Jan O.; Sack, Ingolf; Mangarova, Dilyana B.; Avan, Kader; Taupitz, Matthias; Adams, Lisa C.; Keller, Sarah; Antje, Ludwig; Hamm, Bernd; Botnar, René Michael; Makowski, Marcus R.
- ItemConcurrent Molecular Magnetic Resonance Imaging of Inflammatory Activity and Extracellular Matrix Degradation for the Prediction of Aneurysm Rupture(2019) Brangsch, Julia; Reimann, Carolin; Kaufmann, Jan O.; Adams, Lisa C.; Onthank, David C.; Thone-Reineke, Christa; Robinson, Simon P.; Buchholz, Rebecca; Karst, Uwe; Botnar, Rene M.; Hamm, Bernd; Makowski, Marcus R.BACKGROUND: Molecular magnetic resonance imaging is a promising modality for the characterization of abdominal aortic aneurysms (AAAs). The combination of different molecular imaging biomarkers may improve the assessment of the risk of rupture. This study investigates the feasibility of imaging inflammatory activity and extracellular matrix degradation by concurrent dual-probe molecular magnetic resonance imaging in an AAA mouse model.