Browsing by Author "Kader, Avan"

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    ADAMTS4-specific MR probe to assess aortic aneurysms in vivo using synthetic peptide libraries
    (2022) Kaufmann, Jan O.; Brangsch, Julia; Kader, Avan; Saatz, Jessica; Mangarova, Dilyana B.; Zacharias, Martin; Kempf, Wolfgang E.; Schwaar, Timm; Ponader, Marco; Adams, Lisa C.; Moeckel, Jana; Botnar, Rene M.; Taupitz, Matthias; Maegdefessel, Lars; Traub, Heike; Hamm, Bernd; Weller, Michael G.; Makowski, Marcus R.
    New biomarkers are required to improve the assessment of aortic wall integrity and risk of rupture. Here the authors report the development of an imaging probe for ADAMTS4, which they test in an abdominal aortic aneurysm mouse model and show in vivo prediction of aneurysm and rupture.
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    Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis
    (2024) Mangarova, Dilyana Branimirova; Reimann, Carolin; Kaufmann, Jan Ole; Moeckel, Jana; Kader, Avan; Adams, Lisa Christine; Ludwig, Antje; Onthank, David; Robinson, Simon; Karst, Uwe; Helmer, Rebecca; Botnar, Rene; Hamm, Bernd; Makowski, Marcus Richard; Brangsch, Julia
    Atherosclerosis is a chronic inflammatory condition of the arteries and represents the primary cause of various cardiovascular diseases. Despite ongoing progress, finding effective anti-inflammatory therapeutic strategies for atherosclerosis remains a challenge. Here, we assessed the potential of molecular magnetic resonance imaging (MRI) to visualize the effects of 01BSUR, an anti-interleukin-1 beta monoclonal antibody, for treating atherosclerosis in a murine model. Male apolipoprotein E-deficient mice were divided into a therapy group (01BSUR, 2 x 0.3 mg/kg subcutaneously, n = 10) and control group (no treatment, n = 10) and received a high-fat diet for eight weeks. The plaque burden was assessed using an elastin-targeted gadolinium-based contrast probe (0.2 mmol/kg intravenously) on a 3 T MRI scanner. T1-weighted imaging showed a significantly lower contrast-to-noise (CNR) ratio in the 01BSUR group (pre: 3.93042664; post: 8.4007067) compared to the control group (pre: 3.70679168; post: 13.2982156) following administration of the elastin-specific MRI probe (p < 0.05). Histological examinations demonstrated a significant reduction in plaque size (p < 0.05) and a significant decrease in plaque elastin content (p < 0.05) in the treatment group compared to control animals. This study demonstrated that 01BSUR hinders the progression of atherosclerosis in a mouse model. Using an elastin-targeted MRI probe, we could quantify these therapeutic effects in MRI.