Browsing by Author "Jara, X"

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    Effect of endothelin receptor antagonist on parathyroid gland growth, PTH values and cell proliferation in azotemic rats
    (2006) Jara, A; von Höveling, A; Jara, X; Burgos, ME; Valdivieso, A; Mezzano, S; Felsenfeld, AJ
    Background. A variety of stimuli are involved in the pathogenesis of parathyroid gland hyperplasia in renal failure. Recently, it was shown that blocking the signal from the endothelin-1 (ET-1) receptor (ETAR/ETBR) by a non-selective receptor antagonist, bosentan, reduced parathyroid cell proliferation, parathyroid gland hyperplasia and parathyroid hormone (PTH) levels in normal rats on a calcium deficient diet. Our goal was to determine whether in 5/6 nephrectomized (NPX) rats with developing or established hyperparathyroidism, the endothelin receptor blocker, bosentan, reduced the increase in parathyroid cell proliferation, parathyroid gland hyperplasia and PTH values.