Browsing by Author "Jara, Aquiles"

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    Atypical hemolytic uremic syndrome
    (2018) Sepulveda, Rodrigo A.; Tagle, Rodrigo; Jara, Aquiles
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    Expression of gremlin, a bone morphogenetic protein antagonist, is associated with vascular calcification in uraemia
    (OXFORD UNIV PRESS, 2009) Jara, Aquiles; Chacon, Cecilia; Eugenia Burgos, Maria; Droguett, Alejandra; Valdivieso, Andres; Ortiz, Mireya; Troncoso, Pablo; Mezzano, Sergio
    Background. Vascular calcification has been widely recognized as a significant contributor to cardiovascular risk in patients with chronic kidney disease. Recent evidence suggests that BMP-7 decreases the vascular calcification observed in uraemic rats, while BMP-2 could also be participating in this process. Gremlin, a bone morphogenetic protein antagonist, has been detected in rat aortic vascular smooth muscle cells (VSMCs), and since the role of the VSMCs into vascular calcification in uraemia is considered critical in this process, we hypothesized that gremlin could be participating in its pathogenesis. With this aim, we studied its expression in aorta from uraemic rats with calcitriol-induced vascular calcification and in 16-vessel biopsies of uraemic patients undergoing kidney transplantation.
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    Rhabdomyolysis and severe hypercalcemia. Report of one case
    (SOC MEDICA SANTIAGO, 2019) Huidobro E, Juan Pablo; Santander, Jaime; Vicentini, Daniel; Jara, Aquiles
    Rhabdomyolysis (RD) is the process that leads to cell destruction of striated muscle. Causes include inherited metabolic defects or acquired disorders. RD is frequently associated with acute kidney injury (AKI) and disorders of calcium metabolism. We report a 33 year old man that after amphetamine consumption and an uninterrupted 3,000 km driving presented vomiting, muscle pain and dark urine. He had elevated creatinkinase levels, severe hypocalcemia and an acute renal failure. He was treated with hemodialysis and calcitriol. He was transferred to our hospital and on admission a serum calcium of 18 mg/dl was detected. He continued on hemodialysis, recovering renal function and with normalization of creatinkinase levels and serum calcium level.