Browsing by Author "Izmirly, Peter M."
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- ItemAnatomical and pathological findings in hearts from fetuses and infants with cardiac manifestations of neonatal lupus(OXFORD UNIV PRESS, 2012) Llanos, Carolina; Friedman, Deborah M.; Saxena, Amit; Izmirly, Peter M.; Tseng, Chung E.; Dische, Renata; Abellar, Rosanna G.; Halushka, Marc; Clancy, Robert M.; Buyon, Jill P.Objective. The autopsy and clinical information on children dying with anti-SSA/Ro-associated cardiac manifestations of neonatal lupus (cardiac NL) were examined to identify patterns of disease, gain insight into pathogenesis and enhance the search for biomarkers and preventive therapies.
- ItemMaternal and Fetal Factors Associated With Mortality and Morbidity in a Multi-Racial/Ethnic Registry of Anti-SSA/Ro-Associated Cardiac Neonatal Lupus(LIPPINCOTT WILLIAMS & WILKINS, 2011) Izmirly, Peter M.; Saxena, Amit; Kim, Mimi Y.; Wang, Dan; Sahl, Sara K.; Llanos, Carolina; Friedman, Deborah; Buyon, Jill P.Background-Cardiac manifestations of neonatal lupus include conduction disease and, rarely, an isolated cardiomyopathy. This study was initiated to determine the mortality and morbidity of cardiac neonatal lupus and associated risk factors in a multi-racial/ethnic US-based registry to provide insights into the pathogenesis of antibody-mediated injury and data for counseling.
- ItemMaternal Use of Hydroxychloroquine Is Associated With a Reduced Risk of Recurrent Anti-SSA/Ro-Antibody-Associated Cardiac Manifestations of Neonatal Lupus(LIPPINCOTT WILLIAMS & WILKINS, 2012) Izmirly, Peter M.; Costedoat Chalumeau, Nathalie; Pisoni, Cecilia N.; Khamashta, Munther A.; Kim, Mimi Y.; Saxena, Amit; Friedman, Deborah; Llanos, Carolina; Piette, Jean Charles; Buyon, Jill P.Background-A recent case-control study suggested a benefit of hydroxychloroquine (HCQ) in lowering the risk of cardiac manifestations of neonatal lupus (cardiac-NL) in pregnancies of anti-SSA/Ro-positive patients with systemic lupus erythematosus. A historical cohort assembled from 3 international databases was used to evaluate whether HCQ reduces the nearly 10-fold increase in risk of recurrence of cardiac-NL independently of maternal health status.