Browsing by Author "Inostroza, Veronica"

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    Absence of musculocutaneous nerve associated with the presence of an accessory head of the biceps brachii muscle: report of a bilateral case and its clinical implications
    (2023) Farfán Cabello, Emilio Erasmo; Araya, Felipe; Barroilhet Castillo, Manuel; Cornejo, Francisco; Gutierrez, Agustin; Vergara, Matias; Inzunza Hernández, Oscar Alejandro; Sanchez, Natalia; Tramolao Osses, Jaritza Andrea; Inostroza, Veronica
    The anatomical variants of the biceps brachii muscle (BBM) are frequent, mostly unilaterally than bilaterally, and are associated with supernumerary muscle bellies, the total absence of the muscle or one of its heads, and variations in the points of origin and insertion. In the same way, the variants of the musculocutaneous nerve (MCN) can include alterations in its course, number of branches, or anatomical relations, whereas its absence is considered an atypical variation. The aim of this work was to report the absence of musculocutaneous nerve associated with the presence of one accessory head of the biceps brachii muscle. Dissection of a female cadaver, fixed in 10% buff- ered formaldehyde, which did not present previous surgeries in the studied area was performed. Variations were noted in both upper limbs related to accessory muscle bellies and change in innervation. Anatomical relations of muscles and nerves were determined by following proximal to distal ends, relation, vascularization, and innervation pattern. The absence of MCN associated with the presence of one accessory head of the BBM were found bilaterally. These anatomical variations are atypical. Clinically, these variations can produce compressive symptoms that could generate confusing diagnostics and conduce to unnecessary procedures on the arm, inducing iatrogenic actions.
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    Bilateral Variation of the Vertebral Artery: Report of a Case and its Clinical Implication
    (2023) Inostroza, Veronica; Araya, Paulina; Gonzalez, Sofia; Inzunza, Oscar; Tramolao, Jaritza; Farfan, Emilio
    There are many reports on anatomical variations of the vertebral arteries, which may be related to origin, trajectory, caliber, and side. Bilateral variations are less frequent, however, and less common are bilateral variants that differ from each other. The aim of this work was to report the presence of a bilateral variation of the vertebral artery and its functional and clinical implications. Dissection of a female cadaver, fixed in 10 % buffered formaldehyde, which had not undergone any previous surgeries in the study area and had anatomical variations in both vertebral arteries. In each one, follow-up was done from its origin to its end, determining its trajectory, diameters, branching, and anatomical relations. A left vertebral artery was found, starting in the aortic arch and making a sinuous trajectory of 4 curvatures to enter the transverse foramen of C4. The right vertebral artery began as the first branch of the subclavian artery. Its initial trajectory was rectilinear, followed by a right concave curve, a 360 & DEG; loop that included a second ascending curve, and ended straight before entering the transverse foramen of C6. The coexistence of bilateral variations in the vertebral arteries is possible. This atypical situation can potentially generate vascular and neurological pathologies, but with different symptoms and causes. Knowing these variations and deliberately searching for them will enable the specialist to make a suitable differential diagnosis.
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    Evaluation of mandibular anatomy related to sagittal split ramus osteotomy
    (SOC CHILENA ANATOMIA, 2012) Salgado A, Guillermo; Inzunza H, Oscar; Cantin, Mario; Fuentes, Ramon; Inostroza, Veronica; Jesus Errazuriz, Maria; Pavez, Cindy
    Sagittal split ramus osteotomy (SSRO) of the mandible is one of the most common surgical techniques to correct mandibular deformities. In order to prevent many surgical anatomical problems, surgeons have found that further investigation of the anatomical structures related to SSRO is needed. This study aims to investigate positions of the antilingula (AL), inferior alveolar nerve (IAN) and other anatomic landmarks in relation to the lingula of dried mandibles. 70 Chilean dried hemimandibles were studied. The AL, others landmarks and the corresponding position of the L were marked on the internal and external aspect of the mandibular ramus respectively. The distances from the AL, IAN and L were measured in the anterior posterior and the superior inferior planes using a digital caliper and geometric relationship was established. The results showed the AL was discernible in 100% of lateral mandibular rami studied. The most of the AL was found anteriorly to the L with a mean distance of 0.66 +/- 2.43mm and 0.92 +/- 2.56mm, and 4.23 +/- 2.97mm and 3.62 +/- 3.14mm superiorly (right-left sides respectively) (both with p value <0.001). Similar values were seen in relation with IAN. No significant differences were found between the right and left sides, for the majority of parameters. The studied parameters will assist clinicians to determine the anatomical proximity to the IAN, and, minimize the risk of damaging nerver and vessels. We do not recommend the use of antilingula as only anatomical landmark when performing a SSRO procedure.
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    Maternal genotypes of folate/one-carbon metabolism gene variants and nonsyndromic cleft lip with or without cleft palate risk in Chile
    (2021) Inostroza, Veronica; Salamanca, Carlos; Recabarren, Andrea S.; Pantoja, Roberto; Leiva, Noemi; Pardo, Rosa; Suazo, Jose
    The aim of this study was to evaluate, in a case-control design, the association between maternal genotypes for variants in 23 genes involved in folate/one-carbon metabolism and nonsyndromic cleft lip with or without cleft palate (NSCL/P) in a Chilean population. After applying several filters to an Illumina array, we extracted 175 single nucleotide polymorphisms (SNPs) from 150 mothers of NSCL/P cases and 150 control women. Association was evaluated using computed odds ratio (OR) with a 95% confidence interval (95% CI) in additive, recessive, and dominant models. After multiple comparison correction, only SNP rs4451422 (A>C), located 237 bp downstream of the gene encoding the human folylpolyglutamate synthetase (FPGS), maintained a significant association with NSCL/P in the offspring (OR 3.03; 95% CI 1.69-5.26). The variant rs4451422 is associated with a decrease in FPGS expression according to database annotation. Our results lead to a new hypothesis that a lower activity of FPGS enzyme reduces intracellular folate levels and increases the risk of an offspring having NSCL/P.