Browsing by Author "Iglesias, Tomas G."

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    Acute liver failure and liver transplantation secondary to flutamide treatment in a prostate cancer patient
    (2020) Rojas, Pablo A.; Iglesias, Tomas G.; Barrera Martínez, Francisco; Mendez, Gonzalo P.; Torres, Javiera; San Francisco, Ignacio F.
    Flutamide is a first-generation nonsteroidal antiandrogen, used for treatment of advanced prostate cancer (PCa). We present the clinical case of a patient with localized high-risk PCa who started flutamide before radical prostatectomy and evolved with acute liver failure and liver transplantation. Hepatotoxicity induced by antiandrogen therapy, and current indications for first generation anti-androgen therapy were reviewed. To our knowledge, this is the first report of a man diagnosed with PCa who evolved with acute liver failure secondary to flutamide, and finally required liver transplantation.