Browsing by Author "Ibacache Figueroa, Mauricio Enrique"

Now showing 1 - 12 of 12
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    An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis
    (2020) Arab Verdugo, Juan Pablo; Sehrawat, T. S.; Simonetto, D. A.; Verma, V. K.; Feng, D. C.; Tang, T.; Dreyer, K.; Yan, X. Q.; Daley, W. L.; Ibacache Figueroa, Mauricio Enrique; Sanyal, A.; Chalasani, N.; Radaeva, S.; Yang, L.; Vargas, H.; Gao, B.; Gores, G. J.; Malhi, H.; Kamath, P. S.; Shah, V. H.
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    Defective insulin signaling and mitochondrial dynamics in diabetic cardiomyopathy
    (2015) Westermeier, F.; Navarro, M.; Lopez, C.; Bravo, R.; Quiroga Lagos, Clara Rosa; Bustamante, M.; Verdejo Pinochet, Hugo; Zalaquett Sepúlveda, Ricardo; Ibacache Figueroa, Mauricio Enrique; Parra, V.; Castro Gálvez, Pablo Federico; Rothermel, B.A.; Hill, J.A.; Lavandero, S.
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    Dexmedetomidine metabolic clearance is not affected by fat mass in obese patients
    (2018) Rolle, A.; Paredes, S.; Cortínez Fernández, Luis Ignacio; Anderson, B. J.; Quezada Sanhueza, Nicolás; Solari, S.; Allende, Fidel; Torres, J.; Cabrera, D.; Contreras, V.; Carmona, J.; Ramirez, C.; Oliveros, A. M.; Ibacache Figueroa, Mauricio Enrique
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    Dexmedetomidine pharmacokinetics in the obese
    (2015) Cortínez Fernández, Luis Ignacio; Anderson, Brian J.; Holford, Nick H. G.; Puga, Valentina; De La Fuente, Natalia; Auad, Hernán; Solari Gajardo, Sandra; Allende, Fidel; Ibacache Figueroa, Mauricio Enrique
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    Dexmedetomidine protects the heart against ischemia-reperfusion injury by an endothelial eNOS/NO dependent mechanism
    (2016) Riquelme, J.; Westermeier, F.; Hall, A.; Vicencio, J.; Pedrozo, Z.; Ibacache Figueroa, Mauricio Enrique; Fuenzalida Saavedra, Bárbara; Sobrevía Luarte, Luis Alberto; Davidson, S.; Yellon, D.; Sánchez, G.; Lavandero, S.
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    Dexmedetomidine-ketamine combination and caudal block for superficial lower abdominal and genital surgery in children
    (2015) Ibacache Figueroa, Mauricio Enrique; Muñoz, Hernán R.; Fuentes Henríquez, Ricardo Sergio; Cortínez Fernández, Luis Ignacio
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    Differential effects of propofol anaesthesia across three amplitude-defined electroencephalographic states in sedated critically ill term neonates
    (European Society of Anaesthesiology and Intensive Care, 2025) Boncompte Lezaeta, Gonzalo Nicolas; Cortinez Fernández, Luis Ignacio; Toso Milos, Alberto Antonio; Giordano Villatoro, Ady Iveth; Cruzat Riquelme, Francisco Javier; Fuentes, Ricardo; Pedemonte Trewhela, Juan Cristóbal; Contreras Ibacache, Víctor Eliseo; Biggs Muñoz, Daniela Paola; Chiu, Esteban; Ibacache Figueroa, Mauricio Enrique
    The developing neonatal brain displays different electroencephalographic (EEG) responses to GABAergic anaesthetics than adults. Evidence suggests the importance of isoelectric-like activity patterns. However, markers of hypnotic depth are currently lacking for this population. OBJECTIVE To explore potential EEG markers of propofol-induced hypnosis in sedated critically ill term neonates. DESIGN Observational exploratory cohort study. PATIENTS Twenty critically ill term neonates (postmenstrual age 37 to 44 weeks) undergoing intensive care and requiring anaesthesia for noncardiac surgery. Patients with perinatal asphyxia, neurological pathology, brain malformations and metabolic or haemodynamic instability were excluded. INTERVENTION(S) Frontal EEG (Sedline) was recorded before induction and during a 20-min continuous rate propofol infusion. MAIN OUTCOME MEASURES Depending on peak amplitude, segmented EEG signals (1 s epochs) were classified as either isoelectric (<10 μV), low-voltage 10 to 25 μV), or high-voltage (>25 μV). Propofol effects were evaluated in terms of time occupancy and spectral properties within these EEG states. Correlations between clinical variables and EEG states were explored. RESULTS The EEGs of 17 neonates were analysed. Most showed periods of low-voltage (16/17, 94%) and isoelectric states (2/17, 70.5%) before anaesthesia. The time spent in these EEG states increased significantly during propofol infusion; 17/17 (100%), P < 0.001 and 16/17 (94.1%), P = 0.016, respectively. Propofol increased the mean [95% confidence interval (CI)] time spent in the isoelectric state per patient: 12.4 (3.3 to 21.5)% versus 28.6 (14.4 to 42.8)%, P < 0.002. A reduced spectral power was observed across all frequency bands during low-voltage states (all P < 0.026). Gestational age was negatively correlated with time in the isoelectric state; rho, 95% CI, −0.539 (−0.11 to −0.87), P = 0.031. CONCLUSION Our results show that isoelectric periods are common before anaesthesia in our studied population and more frequent in patients born at earlier gestational ages. The data suggest that propofol anaesthesia increases isoelectric EEG states while also reducing the spectral power, specifically during low-voltage EEG states. Potentially, both of these EEG changes could be biomarkers of neonatal hypnosis depth in this particular critically ill subpopulation. TRIAL REGISTRATION ClinicalTrials.gov identifier: NCT04904965.
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    Incidence and risk factors of preoperative anxiety in Spanish-speaking children living in a Spanish-speaking country
    (2020) Arze, Santiago; Lagos C., Claudio; Ibacache Figueroa, Mauricio Enrique; Zamora Helo, Maximiliano; González Arellano, Alejandro
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    Infarto perioperatorio en cirugía no-cardíaca y dexmedetomidina
    (2010) Ibacache Figueroa, Mauricio Enrique; Pedrozo, Z.; Fernández, C.; Sánchez, G.; Lavandero, S.
    La patología cardiovascular es la primera causa de muerte en Chile y en el mundo. Desde el punto de vista quirúrgico, anestesiólogos y cirujanos enfrentan más frecuentemente pacientes mayores con patología cardiovascular. La incidencia de isquemia miocárdica en pacientes de alto riesgo, sometidos a cirugía no-cardíaca, es cercana al 40% durante el perioperatorio. La incidencia de infarto miocárdico y muerte en cirugía no-cardíaca, oscila entre 1 y 5%. Existe una estrecha relación entre los eventos isquémicos perioperatorios y el aumento de la morbimortalidad cardiovascular. Por este motivo, se han desarrollado medidas terapéuticas orientadas a disminuir la incidencia de isquemia perioperatoria y aminorar el daño asociado a ella. La adecuada identificación de pacientes de riesgo, la optimización del tratamiento médico de patologías asociadas y el uso de fármacos cardioprotectores durante el perioperatorio, han mostrado disminuir la incidencia de complicaciones cardíacas. Dexmedetomidina es un agonista á2-adrenérgico de uso frecuente en anestesia. La evidencia sugiere que posee propiedades cardioprotectoras que podrían beneficiar a pacientes quirúrgicos de alto riesgo cardiovascular. La cardioprotección conferida por dexmedetomidina estaría mediada por la modulación del sistema nervioso autónomo. La disminución de la frecuencia cardíaca y de la presión arterial observada durante su uso, evitarían el desbalance entre aporte y demanda de oxígeno miocárdico y atenuarían el estrés sobre placas ateromatosas inestables. Hasta este momento se desconoce si dexmedetomidina produce precondicionamiento cardíaco y si activa vías transduccionales asociadas a cardioprotección. Frente a la actual realidad epidemiológica en Chile y el mundo, es importante estudiar y definir, cuales son los fármacos de uso frecuente en anestesia con capacidad cardloprotectora y los mecanismos Involucrados en esta protección. Sería Interesante lograr dicha definición respecto del uso perloperatorlo de dexmedetomidina.
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    Performance of Propofol Target-Controlled Infusion Models in the Obese : Pharmacokinetic and Pharmacodynamic Analysis
    (2014) Cortínez Fernández, Luis Ignacio; De la Fuente, Natalia; Eleveld, Douglas J.; Oliveros, A. M.; Crovari Eulufi, Fernando; Sepúlveda Varela, Pablo Andrés; Ibacache Figueroa, Mauricio Enrique; Solari Gajardo, Sandra
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    Propofol concentration to induce general anesthesia in children aged 3-11 years with the Kataria effect-site model
    (2015) Fuentes Henríquez, Ricardo Sergio; Cortínez Fernández, Luis Ignacio; Ibacache Figueroa, Mauricio Enrique; Concha P., Mario; Muñoz, Hernán
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    Rocuronium pharmacokinetics and pharmacodynamics in the adductor pollicis and masseter muscles
    (2016) Vega, E. A.; Ibacache Figueroa, Mauricio Enrique; Anderson, B. J.; Holford, N. H. G.; Nazar Jara, C.; Solari Gajardo, Sandra; Allende, Fidel; Cortínez Fernández, Luis Ignacio