Browsing by Author "Hunter, CJ"

Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Cerebral oxygenation during postasphyxial seizures in near-term fetal sheep
    (2005) Gonzalez, H; Hunter, CJ; Bennet, L; Power, GG; Gunn, AJ
    After exposure to asphyxia, infants may develop both prolonged, clinically evident seizures and shorter, clinically silent seizures; however, their effect on cerebral tissue oxygenation is unclear. We therefore examined the hypothesis that the increase in oxygen delivery during postasphyxial seizures might be insufficient to meet the needs of increased metabolism, thus causing a fall in tissue oxygenation, in unanesthetized near-term fetal sheep in utero (gestational age 125 +/- 1 days). Fetuses were administered an infusion of the specific adenosine A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine, followed by 10mins of asphyxia induced by complete umbilical cord occlusion. The fetuses then recovered for 3 days. Sixty-one episodes of electrophysiologically defined seizures were identified in five fetuses. Tissue PO2 (tPO(2)) did not change significantly during short seizures (< 3.5 mins), 5.2 +/- 0.2 versus baseline 5.6 +/- 0.1 mm Hg (NS), but fell to 2.2 +/- 0.2 mm Hg during seizures lasting more than 3.5mins (P < 0.001). During prolonged seizures, cortical blood flow did not begin to increase until tPO(2) had begun to fall, and then rose more slowly than the increase in metabolism, with a widening of the brain to blood temperature gradient. In conclusion, in the immature brain, during prolonged, but not short seizures, there is a transient mismatch between cerebral blood flow and metabolism leading to significant cerebral deoxygenation.