Browsing by Author "Huidobro-Toro, Juan Pablo."
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- ItemA(2b) Adenosine Receptor Mediates Human Chorionic Vasoconstriction and Signals Through Arachidonic Acid Cascade(2005) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemA2-Adrenoceptors Control the Release of Noradrenaline But Not Neuropeptide y From Perivascular Nerve Terminals(2002) Donoso, M. Verónica.; Konig Samohod, Cecilia; Huidobro-Toro, Juan Pablo.
- ItemAdenosine 5'-Triphosphate (Atp), the Neurotransmitter in the Prostatic Portion of the Longitudinal Muscle Layer of the Rat Vas Deferens.(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemAge and castration modulate the inhibitory action of neuropeptide Y on neurotransmission on the rat vas deferens(1991) Bitrán Carreño, Marcela; Huidobro-Toro, Juan Pablo.
- ItemAging Differentially Modifies Arterial Sensitivity to Endothelin-1 and 5-Hydroxytryptamine: Studies in Dog Coronary Arteries and Rat Arterial Mesenteric Bed.(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemBIBP 3226, Suramin and Prazosin Idendify Neuropeptide Y, Adenisine 5'-Triphosphate and Noradrenaline As Sympathetic Cotransmitters in the Rat Arterial Mesenteric Bed(1997) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemBradykinin modulates the release of noradrenaline from vas deferens nerve terminals(1991) Belmar Canales, Jorge; Huidobro-Toro, Juan Pablo.
- ItemCo-release of neuropeptide Y (NPY) and noradrenaline from the sympathetic nerve terminals supplying the rat vas deferens: influence of calcium and the stimulation intensity(1992) Bitrán Carreño, Marcela; Huidobro-Toro, Juan Pablo.
- ItemContribución del neuropéptido y a la fisiología de la co-transmisión simpática humana: Estudios en biopsias de vena safena(2000) Donoso Gomien, María Verónica; Irarrázaval Llona, Manuel José; Morán, Sergio; Zalaquett Sepúlveda, Ricardo; Huidobro-Toro, Juan Pablo.
- ItemDifferential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor(2007) Acuña-Castillo, Claudio.; Bull Simpfendorfer, Paulina; Huidobro-Toro, Juan Pablo.
- ItemDissecting the facilitator and inhibitor allosteric metal sites of the P2X(4) receptor channel - Critical roles of Cys(132) for zinc potentiation and Asp(138) for copper inhibition(2007) Coddou, Claudio.; Bull Simpfendorfer, Paulina; Huidobro-Toro, Juan Pablo.
- ItemEndothelin-1 (ET)-induced mobilization of intracellular Ca2+ stores from the smooth muscle facilitates sympathetic cotransmission by potentiation of adenosine 5′-triphosphate (ATP) motor activity: Studies in the rat vas deferens(1992) Calixto, J. B.; Huidobro-Toro, Juan Pablo.; Lewin Campaña, Jorge.; Donoso Gomien, María Verónica
- ItemExtracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation(2005) Lorca, Ramón.; Bull Simpfendorfer, Paulina; Huidobro-Toro, Juan Pablo.
- ItemFormation of Carnosine-Cu(II) Complexes Prevents and Reverts the Inhibitory Action of Copper in P2x4 and P2x7 Receptors(2002) Coddou, Claudio.; Loeb Luschow, Bárbara; Huidobro-Toro, Juan Pablo.
- ItemHistidine 140 Plays a Key Role in the Inhibitory Modulation of the P2x4 Nucleotide Receptor by Copper But Not Zinc(2003) Coddou, Claudio.; Bull Simpfendorfer, Paulina; Huidobro-Toro, Juan Pablo.
- ItemInvolvement of Eta Receptors in the Facilitation by Endothelin-1 of Non-Adrenergic Non-Cholinergic Transmission in the Rat Urinary Bladder(1994) Donoso Gomien, María Verónica; Huidobro-Toro, Juan Pablo.
- ItemLiberación de Neuropéptido Tirosina (Npy) de los Terminales Nerviosos en Vasos Mamarios(1999) Donoso Gomien, María Verónica; Irarrázaval Llona, Manuel José; Morán, Sergio; Zalaquett Sepúlveda, Ricardo; Huidobro-Toro, Juan Pablo.
- Item[N-methyl-Tyr1,N-methyl-Arg7-D-Leu8]-dynorphin-A-(1-8)ethylamide, a stable dynorphin analog, produces diuresis by kappa-opiate receptor activation in the rat(1992) Huidobro-Toro, Juan Pablo.; Roblero S., Juan; Salas I., Sofía
- ItemNeuropeptide Y inhibits 3[H]noradrenaline release in the rat vas deferens independently of cAMP levels(1996) Bitrán Carreño, Marcela; Huidobro-Toro, Juan Pablo.
- ItemNO production and eNOS phosphorylation induced by epinephrine through the activation of β-adrenoceptors(2009) Figueroa, Xavier; Cortés Mora, Víctor Antonio; Huidobro-Toro, Juan Pablo.; Poblete, Inés; Fernández Acevedo, Ricardo Hernán; Pedemonte Trewhela, Juan CristóbalEpinephrine plays a key role in the control of vasomotor tone; however, the participation of the NO/cGMP pathway in response to β-adrenoceptor activation remains controversial. To evaluate the involvement of the endothelium in the vascular response to epinephrine, we assessed NO production, endothelial NO synthase phosphorylation, and tissue accumulation of cGMP in the perfused arterial mesenteric bed of rat. Epinephrine elicited a concentration-dependent increase in NO (EC50 of 45.7 pM), which was coupled to cGMP tissue accumulation. Both NO and cGMP production were blocked by either endothelium removal (saponin) or NO synthase inhibition (Nω-nitro-l-arginine). Blockade of β1- and β2-adrenoceptors with 1 μM propranolol or β3-adrenoceptor with 10 nM SR 59230A displaced rightward the concentration-NO production curve evoked by epinephrine. Selective stimulation of β1-, β2-, or β3-adrenoceptors also resulted in NO and cGMP production. Propranolol (1 μM) inhibited the rise in NO induced by isoproterenol or the β2-adrenoceptor agonists salbutamol, terbutaline, or fenoterol. Likewise, 10 nM SR 59230A reduced the effects of the β3-adrenoceptor agonists BRL 37344, CGP 12177, SR 595611A, or pindolol. The NO production induced by epinephrine and BRL 37344 was associated with the activation of the phosphatidylinositol 3-kinase/Akt pathway and phosphorylation of eNOS in serine 1177. In addition, in anaesthetized rats, bolus administration of isoproterenol, salbutamol, or BRL 37344 produced NO-dependent reductions in systolic blood pressure. These findings indicate that β1-, β2-, and β3-adrenoceptors are coupled to the NO/cGMP pathway, highlighting the role of the endothelium in the vasomotor action elicited by epinephrine and related β-adrenoceptor agonists.