Browsing by Author "Huidobro-Toro, J"

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    Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT2A and 5-HT2C receptors
    (2002) Acuña-Castillo, C; Villalobos, C; Moya, PR; Sáez, P; Cassels, BK; Huidobro-Toro, J
    1 The pharmacological profile of a series of (+/-)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X = I, Br, NO2, CH3, or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding for rat 5-HT2A or 5-HT2C receptors. The efficacy and relative potency of these drugs were determined and compared to classical 5-HT2 receptor agonists and antagonists.
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    The involvement of neuropeptide YY1 receptors in the blood pressure baroreflex
    (1999) Capurro, D; Huidobro-Toro, J
    To ascertain the role of the neuropeptide Y Y-1 receptors in the vascular manifestations of the sympathetic baroreflex, 10-s bilateral carotid occlusions were performed in anesthetized cats; systemic blood pressure was monitored continually. This maneuver rose systolic blood pressure in 23 +/- 2 mmHg. Following 100 mu g/kg BIBP 3226 or BIBO 3304 i.v., the increase in blood pressure elicited by the occlusions was only 14 +/- 1 and 15 mmHg, respectively. Both BIBP 3226 and BIBO 3304 displaced significantly 5.5 fold rightward the presser dose-response curve elicited by exogenous neuropeptide Y, without altering the norepinephrine curve. Prazosin (10 mu g/kg) reduced the presser response elicited by the carotid occlusion to 12 +/- 4 mmHg. The simultaneous administration of BIBP 3226 plus prazosin rose the systemic blood pressure following the occlusion only 9 +/- 2 mmHg, supporting the involvement of neuropeptide Y in vascular sympathetic reflexes. (C) 1999 Elsevier Science B.V. All rights reserved.