Browsing by Author "Hosgood, H. Dean, III"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010
    (ELSEVIER SCIENCE INC, 2012) Lim, Stephen S.; Vos, Theo; Flaxman, Abraham D.; Danaei, Goodarz; Shibuya, Kenji; Adair Rohani, Heather; Amann, Markus; Anderson, H. Ross; Andrews, Kathryn G.; Aryee, Martin; Atkinson, Charles; Bacchus, Loraine J.; Bahalim, Adil N.; Balakrishnan, Kalpana; Balmes, John; Barker Collo, Suzanne; Baxter, Amanda; Bell, Michelle L.; Blore, Jed D.; Blyth, Fiona; Bonner, Carissa; Borges, Guilherme; Bourne, Rupert; Boussinesq, Michel; Brauer, Michael; Brooks, Peter; Bruce, Nigel G.; Brunekreef, Bert; Bryan Hancock, Claire; Bucello, Chiara; Buchbinder, Rachelle; Bull, Fiona; Burnett, Richard T.; Byers, Tim E.; Calabria, Bianca; Carapetis, Jonathan; Carnahan, Emily; Chafe, Zoe; Charlson, Fiona; Chen, Honglei; Chen, Jian Shen; Cheng, Andrew Tai Ann; Child, Jennifer Christine; Cohen, Aaron; Colson, K. Ellicott; Cowie, Benjamin C.; Darby, Sarah; Darling, Susan; Davis, Adrian; Degenhardt, Louisa; Dentener, Frank; Des Jarlais, Don C.; Devries, Karen; Dherani, Mukesh; Ding, Eric L.; Dorsey, E. Ray; Driscoll, Tim; Edmond, Karen; Ali, Suad Eltahir; Engell, Rebecca E.; Erwin, Patricia J.; Fahimi, Saman; Falder, Gail; Farzadfar, Farshad; Ferrari, Alize; Finucane, Mariel M.; Flaxman, Seth; Fowkes, Francis Gerry R.; Freedman, Greg; Freeman, Michael K.; Gakidou, Emmanuela; Ghosh, Santu; Giovannucci, Edward; Gmel, Gerhard; Graham, Kathryn; Grainger, Rebecca; Grant, Bridget; Gunnell, David; Gutierrez, Hialy R.; Hall, Wayne; Hoek, Hans W.; Hogan, Anthony; Hosgood, H. Dean, III; Hoy, Damian; Hu, Howard; Hubbell, Bryan J.; Hutchings, Sally J.; Ibeanusi, Sydney E.; Jacklyn, Gemma L.; Jasrasaria, Rashmi; Jonas, Jost B.; Kan, Haidong; Kanis, John A.; Kassebaum, Nicholas; Kawakami, Norito; Khang, Young Ho; Khatibzadeh, Shahab; Khoo, Jon Paul; Kok, Cindy; Laden, Francine; Lalloo, Ratilal; Lan, Qing; Lathlean, Tim; Leasher, Janet L.; Leigh, James; Li, Yang; Lin, John Kent; Lipshultz, Steven E.; London, Stephanie; Lozano, Rafael; Lu, Yuan; Mak, Joelle; Malekzadeh, Reza; Mallinger, Leslie; Marcenes, Wagner; March, Lyn; Marks, Robin; Martin, Randall; McGale, Paul; McGrath, John; Mehta, Sumi; Mensah, George A.; Merriman, Tony R.; Micha, Renata; Michaud, Catherine; Mishra, Vinod; Hanafiah, Khayriyyah Mohd; Mokdad, Ali A.; Morawska, Lidia; Mozaffarian, Dariush; Murphy, Tasha; Naghavi, Mohsen; Neal, Bruce; Nelson, Paul K.; Miquel Nolla, Joan; Norman, Rosana; Olives, Casey; Omer, Saad B.; Orchard, Jessica; Osborne, Richard; Ostro, Bart; Page, Andrew; Pandey, Kiran D.; Parry, Charles D. H.; Passmore, Erin; Patra, Jayadeep; Pearce, Neil; Pelizzari, Pamela M.; Petzold, Max; Phillips, Michael R.; Pope, Dan; Pope, C. Arden, III; Powles, John; Rao, Mayuree; Razavi, Homie; Rehfuess, Eva A.; Rehm, Juergen T.; Ritz, Beate; Rivara, Frederick P.; Roberts, Thomas; Robinson, Carolyn; Rodriguez Portales, Jose A.; Romieu, Isabelle; Room, Robin; Rosenfeld, Lisa C.; Roy, Ananya; Rushton, Lesley; Salomon, Joshua A.; Sampson, Uchechukwu; Sanchez Riera, Lidia; Sanman, Ella; Sapkota, Amir; Seedat, Soraya; Shi, Peilin; Shield, Kevin; Shivakoti, Rupak; Singh, Gitanjali M.; Sleet, David A.; Smith, Emma; Smith, Kirk R.; Stapelberg, Nicolas J. C.; Steenland, Kyle; Stoeckl, Heidi; Stovner, Lars Jacob; Straif, Kurt; Straney, Lahn; Thurston, George D.; Tran, Jimmy H.; Van Dingenen, Rita; van Donkelaar, Aaron; Veerman, J. Lennert; Vijayakumar, Lakshmi; Weintraub, Robert; Weissman, Myrna M.; White, Richard A.; Whiteford, Harvey; Wiersma, Steven T.; Wilkinson, James D.; Williams, Hywel C.; Williams, Warwick; Wilson, Nicholas; Woolf, Anthony D.; Yip, Paul; Zielinski, Jan M.; Lopez, Alan D.; Murray, Christopher J. L.; Ezzati, Majid
    Background Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a disease-by-disease analysis. No complete revision of global disease burden caused by risk factors has been done since a comparative risk assessment in 2000, and no previous analysis has assessed changes in burden attributable to risk factors over time.
  • Thumbnail Image
    Item
    PRDM15 Is Associated with Risk of Chronic Obstructive Pulmonary Disease in a Rural Population in Chile
    (KARGER, 2020) Hosgood, H. Dean, III; Diaz Pena, Roberto; Blansky, Deanna; Jaime, Sergio; Parra, Viviana; Boekstegers, Felix; Bermejo, Justo Lorenzo; Garcia Valero, Jose; Montes, Juan F.; Valdivia, Gonzalo; Miravitlles, Marc; Agusti, Alvar; Silva, Rafael S.; Olloquequi, Jordi
    Background: Genome-wide association studies (GWAS) have accelerated our understanding of the genetic underpinnings of chronic obstructive pulmonary disease (COPD); however, GWAS populations have typically consisted of European descent, with similar to 1% of Latin American ancestry. Objective: To overcome this limitation, we conducted a GWAS in a rural Chilean population with increased COPD risk to investigate genetic variation of COPD risk in this understudied minority population. Method: We carried out a case-control study of 214 COPD patients (defined by the GOLD criteria) and 193 healthy controls in Talca, Chile. DNA was extracted from venous blood and genotyped on the Illumina Global Screening Array (n = 754,159 markers). After exclusion based on Hardy-Weinberg equilibrium (p <= 0.001), call rates (<95%), and minor allele frequencies (<0.5%) in controls, 455,564 markers were available for logistic regression. Results: PRDM15 rs1054761 C allele (p = 2.22 x 10(-7)) was associated with decreased COPD risk. Three PRDM15 SNPs located on chromosome 21 were significantly associated with COPD risk (p < 10(-6)). Two of these SNPs, rs1054761 and rs4075967, were located on a noncoding transcript variant region of the gene. Conclusion: PRDM15 overexpression may play a role in the B-cell dysregulation in COPD pathogenesis. To the best of our knowledge, the association between PRDM15 and COPD risk was not previously found in GWAS studies in largely European populations, highlighting the importance of investigating novel variants associated with COPD risk among ethnically diverse populations.