Browsing by Author "Hjelle, B"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Hantavirus prevalence in the IX Region of Chile
    (CENTERS DISEASE CONTROL & PREVENTION, 2003) Frey, MT; Vial, PC; Castillo, CH; Godoy, PM; Hjelle, B; Ferres, MG
    An epidemiologic and seroprevalence survey was conducted (n=830) to assess the proportion of persons exposed to hantavirus in IX Region Chile, which accounts for 25% of reported cases of hantavirus cardiopulmonary syndrome. This region has three geographic areas with different disease incidences and a high proportion of aboriginals. Serum samples were tested for immunoglobulin (Ig) G antibodies by enzyme-linked immunosorbent assay against Sin Nombre virus N antigen by strip immunoblot assay against Sin Nombre, Puumala, Rio Mamore, and Seoul N antigens. Samples from six patients were positive for IgG antibodies reactive with Andes virus; all patients lived in the Andes Mountains. Foresting was also associated with seropositivity; but not sex, age, race, rodent exposure, or farming activities. Exposure to hantavirus varies in different communities of IX Region. Absence of history of pneumonia or hospital admission in persons with specific IgG antibodies suggests that infection is clinically inapparent.
  • Thumbnail Image
    Item
    Neutralizing antibodies in survivors of Sin Nombre and Andes hantavirus infection
    (CENTERS DISEASE CONTROL, 2006) Valdivieso, F; Vial, P; Ferres, M; Ye, CY; Goade, D; Cuiza, A; Hjelle, B
    We evaluated titers of homotypic and heterotypic neutralizing antibodies (NAbs) to Andes and Sin Nombre hantaviruses in plasma samples from 20 patients from Chile and the United States. All but 1 patient had high titers of NAb. None of the plasma samples showed high titers against the heterologous virus.