Browsing by Author "Henningsson, Markus"
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- Item3D myocardial T-1 mapping using saturation recovery(2017) Nordio, Giovanna; Henningsson, Markus; Chiribiri, Amedeo; Villa, Adriana D. M.; Schneider, Torben; Botnar, René Michael
- Item3D SASHA myocardial T1 mapping with high accuracy and improved precision(2019) Nordio, Giovanna; Bustin, Aurélien; Henningsson, Markus; Rashid, Imran; Chiribiri, Amedeo; Ismail, Tevfik; Odille, Freddy; Prieto Vásquez, Claudia; Botnar, René Michael
- ItemA clinical combined gadobutrol bolus and slow infusion protocol enabling angiography, inversion recovery whole heart, and late gadolinium enhancement imaging in a single study(2016) Tandon, Animesh; James, Lorraine; Henningsson, Markus; Botnar, René Michael; Potersnak, Amanda; Greil, Gerald F; Hussain, TariqueAbstract Background The use of gadolinium contrast agents in cardiovascular magnetic resonance is well-established and serves to improve both vascular imaging as well as enable late gadolinium enhancement (LGE) imaging for tissue characterization. Currently, gadofosveset trisodium, an intravascular contrast agent, combined with a three-dimensional inversion recovery balanced steady state free precession (3D IR bSSFP) sequence, is commonly used in pediatric cardiac imaging and yields excellent vascular imaging, but cannot be used for late gadolinium enhancement. Gadofosveset use remains limited in clinical practice, and manufacture was recently halted, thus an alternative is needed to allow 3D IR bSSFP and LGE in the same study. Methods Here we propose a protocol to give a bolus of 0.1 mL/kg = 0.1 mmol/kg gadobutrol (GADAVIST/GADOVIST) for time-resolved magnetic resonance angiography (MRA). Subsequently, 0.1 mmol/kg is diluted up to 5 or 7.5 mL with saline and then loaded into intravenous tubing connected to the patient. A 0.5 mL short bolus is infused, then a slow infusion is given at 0.02 or 0.03 mL/s. Image navigated (iNAV) 3D IR bSSFP imaging is initiated 45–60 s after the initiation of the infusion, with a total image acquisition time of ~5 min. If necessary, LGE imaging using phase sensitive inversion recovery reconstruction (PSIR) is performed at 10 min after the infusion is initiated. Results We have successfully performed the above protocol with good image quality on 10 patients with both time-resolved MRA and 3D IR bSSFP iNAV imaging. Our initial attempts to use pencil beam respiratory navigation failed due to signal labeling in the liver by the navigator. We have also performed 2D PSIR LGE successfully, with both LGE positive and LGE negative results. Conclusion A bolus of gadobutrol, followed later by a slow infusion, allows time-resolved MRA, 3D IR bSSFP using the iNAV navigation technique, and LGE imaging, all in a single study with a single contrast agent.
- ItemCombined coronary lumen and vessel wall magnetic resonance imaging with i-T2prep : influence of nitroglycerin(2015) Hussain, Tarique; Henningsson, Markus; Butzbach, Britta; Lossnitzer, Dirk; Greil, Gerald F.; Andía Kohnenkampf, Marcelo Edgardo; Botnar, René Michael
- ItemCorrection to: 3D SASHA myocardial T1 mapping with high accuracy and improved precision(2018) Nordio, Giovanna ; Bustin, Aurelien; Henningsson, Markus; Rashid, Imran ; Chiribiri, Amedeo ; Ismail, Tevfik ; Odille, Freddy; Prieto, Claudia; Botnar, Rene Michael
- ItemFlow-independent 3D whole-heart vessel wall imaging using an interleaved T2-preparation acquisition(2013) Andía Kohnenkampf, Marcelo Edgardo; Henningsson, Markus; Hussain, Tarique; Phinikaridou, Alkystis; Protti, Andrea; Greil, Gerald; Botnar, René Michael
- ItemHighly Efficient Nonrigid Motion-Corrected 3D Whole-Heart Coronary Vessel Wall Imaging(2017) Cruz, Gastao; Atkinson, David; Henningsson, Markus; Botnar, René Michael; Prieto Vásquez, Claudia
- ItemImproved coronary magnetic resonance angiography using gadobenate dimeglumine in pediatric congenital heart disease(2018) Silva Vieira, Miguel; Henningsson, Markus; Dedieu, Nathalie; Vassiliou, Vassilios S.; Bell, Aaron; Mathur, Sujeev; Pushparajah, Kuberan; Figueroa, Carlos Alberto; Hussain, Tarique; Botnar, René Michael; Greil, Gerald F.
- ItemInitial results of the Hyperion II DPET insert for simultaneous PET-MRI applied to atherosclerotic plaque imaging in New-Zealand white rabbits(IOP Publishing Ltd, 2024) Gebhardt, Pierre; Lavin, Begoña; Phinikaridou, Alkystis; Mackewn, Jane E.; Henningsson, Markus; Schug, David; Salomon, Andre; Marsden, Paul K.; Schulz, Volkmar; Botnar, René MichaelObjective. In preclinical research, in vivo imaging of mice and rats is more common than any other animal species, since their physiopathology is very well-known and many genetically altered disease models exist. Animal studies based on small rodents are usually performed using dedicated preclinical imaging systems with high spatial resolution. For studies that require animal models such as mini-pigs or New-Zealand White (NZW) rabbits, imaging systems with larger bore sizes are required. In case of hybrid imaging using positron emission tomography (PET) and magnetic resonance imaging (MRI), clinical systems have to be used, as these animal models do not typically fit in preclinical simultaneous PET-MRI scanners. Approach. In this paper, we present initial imaging results obtained with the Hyperion IID PET insert which can accommodate NZW rabbits when combined with a large volume MRI RF coil. First, we developed a rabbit-sized image quality phantom of comparable size to a NZW rabbit in order to evaluate the PET imaging performance of the insert under high count rates. For this phantom, radioactive spheres with inner diameters between 3.95 and 7.86mm were visible in a warm background with a tracer activity ratio of 4.1 to 1 and with a total 18F activity in the phantom of 58MBq at measurement start. Second, we performed simultaneous PET-MR imaging of atherosclerotic plaques in a rabbit in vivo using a single injection containing 18F-FDG for detection of inflammatory activity, and Gd-ESMA for visualization of the aortic vessel wall and plaques with MRI. Main results. The fused PET-MR images reveal 18F-FDG uptake within an active plaques with plaque thicknesses in the sub-millimeter range. Histology showed colocalization of 18F-FDG uptake with macrophages in the aortic vessel wall lesions. Significance. Our initial results demonstrate that this PET insert is a promising system for simultaneous high-resolution PET-MR atherosclerotic plaque imaging studies in NZW rabbits.
- ItemSimultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling After Myocardial Infarction(2018) Ramos, Isabel T.; Henningsson, Markus; Nezafat, Maryam; Lavín, Begoña; Lorrio, Silvia; Gebhardt, Pierre; Protti, Andrea; Eykyn, Thomas R.; Andía Kohnenkampf, Marcelo Edgardo; Botnar, René Michael; Floögel, Ulrich; Phinikaridou, Alkystis; Shah, Ajay M.