Browsing by Author "Harris D., Paul R."

Now showing 1 - 20 of 46
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    Alta frecuencia de pancreatitis aguda asociada a patología biliar en niños chilenos
    (2011) Pattillo Silva, Juan Carlos; Montecinos, G. A.; Luque, M. J. H.; Harris D., Paul R.
    La pancreatitis aguda (PA) en niños presenta una morbimortalidad considerable. Las etiologías más frecuentes en este grupo etario son la PA secundaria a trauma, por enfermedades sistémicas y la PA idiopática, a diferencia de la población adulta en que predomina la litiasis biliar y el consumo de alcohol. En Chile, donde la patología biliar es altamente prevalente, existe escasa información clínica respecto de la PA en niños. Objetivo: Determinar las características clínicas de la pancreatitis aguda en un grupo de niños chilenos. Método: Estudio retrospectivo (1998-2008) de pacientes hospitalizados con PA. Se confirmó el diagnóstico por elevación de enzimas pancreáticas e imágenes; se obtuvieron los datos demográficos y se analizó: etiología, complicaciones y su resolución, necesidad de nutrición parenteral y uso de antibióticos. Resultados: Se identificaron 18 pacientes (8,3 ± 4 años). Etiología de la PA: litiasis y alteraciones anatómicas de la vía biliar (38,8%), idiopática (22,2%), drogas (22,2%), otras (16.8%). Dos pacientes presentaron colecciones peripancreáticas infectadas; igual número evolucionó con formación de pseudoquistes pancreáticos. Seis pacientes (33,3%) requirieron algún tipo de procedimiento quirúrgico como parte de su tratamiento. Dos tercios de los pacientes ingresaron a la Unidad de Pacientes Críticos. La mitad de los pacientes recibió nutrición parenteral y dos tercios antibióticos endovenosos. La mediana de hospitalización fue de 20 días (promedio 24,9 ± 14,3 días). No hubo mortalidad en la serie. Conclusiones: A diferencia de lo descrito en la literatura, la PA biliar fue la etiología más frecuente en esta serie. La patología biliar debe ser estudiada activamente en niños chilenos con PA.
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    Alteraciones polisomnográficas en lactantes con reflujo gastroesofágico
    (SOC MEDICA SANTIAGO, 2003) Harris D., Paul R.; Brockmann Veloso, Pablo Edmundo; Muñoz O., Carla; Mobarec Katunaric, Sebastián Ignacio; Mesa Latorre, Manuel Tomás; Sánchez Díaz, Ignacio
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    Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells
    (2014) Das, Soumita; Sarkar, Arup; Ryan, Kieran A.; Fox, Sarah; Berger, Alice H.; Juncadella, Ignacio J.; Bimczok, Diane; Smythies, Lesley E.; Harris D., Paul R.; Ravichandran, Kodi S.; Crowe, Sheila E.; Smith, Phillip D.; Ernst, Peter B.
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    Características clínicas asociadas a colitis eosinofílica en lactantes con rectorragia persistente
    (2014) Romero, Bernardita; Talesnik Guendelman, Eduardo; Cerda, Jaime; Harris D., Paul R.
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    Commentary : duodenal intraepithelial lymphocytosis in children without coeliac disease
    (2014) Walker, M. M.; Harris D., Paul R.; Crabtree, J. E.
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    Correlación genotipo-fenotipo de un grupo de pacientes con fibrosis quística
    (Soc. Médica Santiago, 2002) Navarro M., Héctor; Kolbach Rengifo, Marianne Helene; Repetto Lisboa, María Gabriela; Guiraldes Cameratti, Ernesto; Harris D., Paul R.; Foradori, Arnaldo; Poggi, Helena; Sánchez Díaz, Ignacio
    Background: Cystic fibrosis (CF) is the most common lethal autosomic disease in Caucasians, with a global incidence of 1:3000 newborns. More than 900 mutations have been described, involving the Cystic Fibrosis Transmembrane Regulator (CFTR). The delta F508 mutation is present in 60% of alleles studied worldwide.Aim: To report 25 patients with cystic fibrosis in whom a genetic study was done.Material and methods: Twenty five patients (14 men, aged between 18 months and 25 years) with a diagnosis of cystic fibrosis based on clinical features plus two abnormal sweat tests are reported. The genetic study considered the 20 most common mutations in cystic fibrosis and was done in genomic DNA of peripheral lymphocytes, by polymerase chain reaction.Results: A mutation was found in 75% of analyzed alleles. delta F508 was present in 50% of cases (delta F508/delta F508 in 8 and delta F508/other in 11). When delta F508 was present, pancreatic insufficiency was always a feature and nutritional status was worse. Respiratory involvement was variable, both for homozygous and heterozygous cases. Other severe mutations such as W128X and G542X were related to clinical manifestations similar to those found in delta F508 mutation. Diagnosis was made before six months of age in 12 patients. The clinical presentation was meconium ileus and there was a family history of the disease in most cases. The majority of cases of early diagnosis presented severe mutations, but milder respiratory symptoms and lesser nutritional compromise at the time of assessment.Conclusions: Most patients studied had a severe cystic fibrosis mutation, which was associated with more severe respiratory, pancreatic and nutritional involvement. The early diagnosis of the disease, which would allow to improve the prognosis and the quality of life, must be emphasized.
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    Desarrollo de la Microbiota Gastrointestinal en Lactantes y Su Rol en Salud y Enfermedad
    (2016) Serrano Honeyman, Carolina; León, M. A.; Harris D., Paul R.; Serrano Honeyman, Carolina; León, M. A.; Harris D., Paul R.
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    Desarrollo del microbioma intestinal en niños: impacto en salud y enfermedad
    (2016) Serrano Honeyman, Carolina; Harris D., Paul R.; Serrano Honeyman, Carolina; Harris D., Paul R.
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    Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori-infected children
    (2013) Serrano Honeyman, Carolina; Venegas Muñoz, Alejandro Andrés; Harris D., Paul R.; Serrano Honeyman, Carolina; Venegas Muñoz, Alejandro Andrés; Harris D., Paul R.
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    Early origins of allergy and asthma (ARIES): study protocol for a prospective prenatal birth cohort in Chile.
    (2020) Hernández Vargas, Caroll Daffner; Casanello Toledo, Paola Cecilia; Harris D., Paul R.; Castro Rodríguez, José Antonio; Iturriaga, Carolina; Pérez Mateluna, Guillermo; Farías Jofré, Marcelo Enrique; Urzúa, Marcela; Hernández Carreño, Cherie Francisca; Serrano Honeyman, Carolina; Hernández Vargas, Caroll Daffner; Casanello Toledo, Paola Cecilia; Harris D., Paul R.; Castro Rodríguez, José Antonio; Iturriaga, Carolina; Pérez Mateluna, Guillermo; Farías Jofré, Marcelo Enrique; Urzúa, Marcela; Hernández Carreño, Cherie Francisca; Serrano Honeyman, Carolina
    Abstract Background Growing evidence shows that atopic dermatitis (AD), food allergy (FA), allergic rhinitis, and asthma are largely determined during the first 1000 days (time elapsed from conception to the 2nd birthday). The ARIES birth cohort aims to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in the later determination of the risk of allergic diseases and asthma in the offspring. Methods We have designed a birth cohort of 250 families with prenatal recruitment (~ 14 weeks). We will genotype relevant allergy/asthma-associated variants in trios and will perform immunophenotyping and evaluation of allergy biomarkers in cord blood. At 1 and 2 years of age we will assess if infants have developed allergic sensitization, AD, FA, as well as biomarkers of asthma including the asthma predictive index. We will also evaluate how maternal conditions modify immune programming through epigenetic modifications and will then depict newborn epigenetic cues of allergy/asthma risk. Next, we will assess composition/diversity of maternal gut, placenta, breastmilk and infant gut microbiome and their association with immunophenotype and biomarkers at birth, and clinical outcomes at age 1 and 2. Finally, we plan to assess how environmental exposures (perinatal outdoor and indoor pollution, allergens and endotoxin) affect the incidence of allergic sensitization, AD, FA, and risk of asthma. Discussion The in-depth study of the ARIES birth cohort shall provide crucial information to understand the rising incidence of allergies and asthma in developing countries, and hopefully provide cues on how to prevent and treat these diseases. Trial registration clinicaltrials.gov NCT04186949, retrospectively registered on December 5, 2019.
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    Eradication of Helicobacter pylori in Children Restores the Structure of the Gastric Bacterial Community to That of Noninfected Children
    (2019) Serrano Honeyman, Carolina; Pierre, Reinaldo; Van Der Pol, William J.; Morrow, Casey D.; Smith, Phillip D.; Harris D., Paul R.; Serrano Honeyman, Carolina; Pierre, Reinaldo; Van Der Pol, William J.; Morrow, Casey D.; Smith, Phillip D.; Harris D., Paul R.
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    Estudio de validez diagnóstica de la prueba de hemorragia oculta fecal en lactantes con proctocolitis alérgica inducida por proteína alimentaria
    (2018) Concha, Sara; Cabalín, Carolina; Iturriaga, Carolina; Pérez Mateluna, Guillermo; Gómez, Constanza; Cifuentes, Lorena; Harris D., Paul R.; Gana Ansaldo, Juan Cristóbal; Borzutzky Schachter, Arturo
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    Estudio multicéntrico sobre la epidemiologia de la Esofagitis Eosinofílica Pediátrica en América Latina
    (2016) Pierre, Reinaldo; Vieira, Mario; Vasquez Frias, Rodrigo; Nimoniya, Ines; Messere, Gabriela; Daza, Wilson; Dadan, Silvana; Harris D., Paul R.
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    Evolución prolongada en síndrome de crigler-najjar tipo I
    (2014) Besa, S.; Calvo, C.; Harris D., Paul R.
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    Genome sequencing and analysis of the biomass-degrading fungus Trichoderma reesei (syn. Hypocrea jecorina)
    (2008) Martínez, Diego; Harris D., Paul R.; Larrondo Castro, Luis Fernando
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    Helicobacter pylori HopE and HopV porins present scarce expression among clinical isolates
    (2010) Lienlaf, M.; Morales Martínez, Juan Pablo.; Díaz Morales, María Inés; Harris D., Paul R.
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    Helicobacter pylori Infection Inhibits Phagocyte Clearance of Apoptotic Gastric Epithelial Cells
    (2013) Bimczok, D.; Smythies, L.; Waites, K.; Grams, J.; Stahl, R.; Mannon, P.; Shajan, P.; Wilcox, C.; Harris D., Paul R.; Das, S.; Ernst, P.; Smith, P.
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    Helicobacter pylori infection is associated with an altered gastric microbiota in children
    (2017) Brawner, K.; Kumar, R.; Serrano Honeyman, Carolina; Ptacek, T.; Lefkowitz, E.; Morrow, C.; Zhi, D.; Kyanam, K.; Smythies, L.; Harris D., Paul R.; Smith, P.; Brawner, K.; Kumar, R.; Serrano Honeyman, Carolina; Ptacek, T.; Lefkowitz, E.; Morrow, C.; Zhi, D.; Kyanam, K.; Smythies, L.; Harris D., Paul R.; Smith, P.
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    Helicobacter pylori Infection Is Associated with Decreased Expression of SLC5A8, a Cancer Suppressor Gene, in Young Children
    (2016) Orellana Manzano, Andrea; O’Ryan, Miguel G.; Lagomarcino, Anne J.; George, Sergio; Muñoz, Mindy S.; Mamani, Nora; Serrano Honeyman, Carolina; Harris D., Paul R.; Ramilo, Octavio; Mejías, Asunción; Torres, Juan P.; Lucero, Yalda; Quest, Andrew F. G.; Orellana Manzano, Andrea; O’Ryan, Miguel G.; Lagomarcino, Anne J.; George, Sergio; Muñoz, Mindy S.; Mamani, Nora; Serrano Honeyman, Carolina; Harris D., Paul R.; Ramilo, Octavio; Mejías, Asunción; Torres, Juan P.; Lucero, Yalda; Quest, Andrew F. G.