Browsing by Author "Harrington, RA"
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- ItemAssociation between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation(2000) Alexander, JH; Sparapani, RA; Mahaffey, KW; Deckers, JW; Newby, LK; Ohman, EM; Corbalán, R; Chierchia, SL; Boland, JB; Simoons, ML; Califf, RM; Topol, EJ; Harrington, RAContext Controversy surrounds the diagnostic and prognostic importance of slightly elevated cardiac markers in patients with acute coronary syndromes without ST-segment elevation.
- ItemDisagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study(2001) Mahaffey, KW; Harrington, RA; Akkerhuis, M; Kleiman, NS; Berdan, LG; Crenshaw, BS; Tardiff, BE; Granger, CB; DeJong, I; Bhapkar, M; Widimsky, P; Corbalon, R; Lee, KL; Deckers, JW; Simoons, ML; Topol, EJ; Califf, RMBackground Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions (MIs) reported by site investigators in the international Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial and those adjudicated by a central clinical events committee (CEC) to determine the reasons for differences in event rates.
- ItemVariation in patient management and outcomes for acute coronary syndromes in Latin America and North America(2001) Cohen, MG; Pacchiana, CM; Corbalán, R; Perez, JEI; Ponte, CI; Oropeza, ES; Diaz, R; Paolasso, E; Izasa, D; Rodas, MA; Urrutia, CE; Harrington, RA; Topol, EJ; Califf, RMBackground Although more than 9500 patients have been enrolled in molar clinical trials in Latin America, practice patterns in this region have rarely been examined. We sought to compare characteristics, resource utilization, and outcomes of patients treated For acute coronary syndromes in Latin America with those in North America.