Browsing by Author "Guglielmetti, Antonio"

Now showing 1 - 4 of 4
  • No Thumbnail Available
    Item
    Autologous fibroblasts for the treatment of cutaneous loxoscelism: First experience
    (2019) Guglielmetti, Antonio; Jahr, Catalina; Gompertz-Mattar, Matias
    Several treatments have been described for cutaneous loxoscelism (CL), but the quality of available evidence is insufficient for the elaboration of a therapeutic consensus. Dapsone has shown beneficial effects on stopping the inflammatory phenomenon and accelerating the recovery. It is recommended to start dapsone once the visceral involvement is ruled out if glucose-6-phosphate dehydrogenase levels are normal. Autologous fibroblast (AF) therapy is a novel therapy that has been successfully used in bioengineering as skin substitutes for surgical wounds and burns, diabetic and pressure ulcers, and other aesthetic purposes. Interestingly, there are no reports of AFs in CL. We present a case of CL in which the necrotic process was stabilised with dapsone, but the healing of the ulcer was not achieved. Three weekly applications of AFs 100 000/cm(2) were performed on a biocompatible polymer matrix, with optimal response within 2 months. This represents the first report of AFs in CL, setting the stage for future studies.
  • No Thumbnail Available
    Item
    Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis
    (2022) Valenzuela, Fernando; De La Cruz, Claudia; Lecaros, Cristobal; Fernandez, Javier; Hevia, Gonzalo; Maul, Lara Valeska; Thyssen, Jacob P.; Vera-Kellet, Cristian; Egeberg, Alexander; Armijo, Daniela; Pizarro, Cristian; Riveros, Tatiana; Correa, Hernan; Guglielmetti, Antonio; Didaskalu, Johannes A.; Wu, Jashin J.; Griffiths, Christopher E. M.; Romiti, Ricardo; Maul, Julia-Tatjana
    Background Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America. Aim To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis. Methods This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression. Results In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 +/- 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 +/- 11.5; body surface area 14.7 +/- 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis. Conclusions We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.
  • Thumbnail Image
    Item
    Lewandowsky's Rosaceiform Eruption : a Form of Cutaneous Tuberculosis Confirmed by PCR in Two Patients
    (2015) Conlledo, Rodrigo; Guglielmetti, Antonio; Sobarzo, Macarena; Woolvett, Francisca; Bravo, Francisca; González Bombardiere, Sergio; Fich, Félix; Vial, Verónica
  • No Thumbnail Available
    Item
    Remission of refractory metastatic Crohn's disease achieved with dapsone
    (2018) Guglielmetti, Antonio; Gompertz, Matías; Jahr, Catalina; Silva, Tomás; González Bombardiere, Sergio