Browsing by Author "Grotto, Denise"
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- ItemBackground Values for Essential and Toxic Elements in Children's Nails and Correlation with Hair Levels(2011) Hornos Carneiro, María Fernanda; Grotto, Denise; Lemos Batista, Bruno; Ramos Rhoden,Claudia; Barbosa, Fernando, Jr.
- ItemEvaluation of the Concentration of Nonessential and Essential Elements in Chicken, Pork, and Beef Samples Produced in Brazil(2012) Batista, Bruno Lemos; Grotto, Denise; Hornos Carneiro, María Fernanda; Barbosa, Fernando, Jr.
- ItemExploring the impact of Agaricus bisporus on mitigating lead reproductive toxicity using the Caenorhabditis elegans model(2024) Caetano, Erika Leao Ajala; Miguel, Francisco Javier Novoa San; Leon, Rocio Errazuriz; Grotto, Denise; Carneiro, Maria Fernanda HornosGiven that Agaricus bisporus, an edible mushroom, has demonstrated antioxidant properties, our investigation aimed to assess whether Agaricus bisporus could mitigate the toxic effects of lead (Pb) on Caenorhabditis elegans (C. elegans) model. A dose-response study was conducted involving Pb and Agaricus bisporus to determine appropriate doses. Subsequently, a co-exposure study utilizing C. elegans strains N2 and CL2166 was implemented, with groups designated as Control, Pb, Agaricus bisporus, and Pb + Agaricus bisporus. Our findings revealed that co-exposure to Pb + 100 mg/mL Agaricus bisporus resulted in reduced embryonic and larval lethality, increased brood size, and enhanced motility compared to nematodes exposed solely to Pb. Notably, our observations indicated a transfer of reproductive toxicity from nematode parents to their offspring. Thus, Agaricus bisporus may play a significant role in Pb detoxification, suggesting its potential as a natural antioxidant for neutralizing the detrimental effects of Pb on reproductive health.