Browsing by Author "Grez, Paula M."

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    Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification
    (2009) Minniti, Alicia N.; Rebolledo, Daniela L.; Grez, Paula M.; Fadic, Ricardo; Aldunate, Rebeca; Volitakis, Irene; Cherny, Robert A.; Opazo, Carlos; Masters, Colin; Bush, Ashley I.; Inestrosa, Nibaldo C.
    Background: The amyloid beta-peptide is a ubiquitous peptide, which is prone to aggregate forming soluble toxic oligomers and insoluble less-toxic aggregates. The intrinsic and external/environmental factors that determine A beta aggregation in vivo are poorly understood, as well as the cellular meaning of this process itself. Genetic data as well as cell biological and biochemical evidence strongly support the hypothesis that A beta is a major player in the onset and development of Alzheimer's disease. In addition, it is also known that A beta is involved in Inclusion Body Myositis, a common myopathy of the elderly in which the peptide accumulates intracellularly.