Browsing by Author "Grassi Corrales, Bruno"

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    A Call-to-Action to Eliminate Barriers to Accessing Automated Insulin Delivery Systems for People with Type 1 Diabetes
    (Mary Ann Liebert Inc., 2025) Saboo, B.; Garg, S.; Bergenstal, R.M.; Battelino, T.; Ceriello, A.; Choudhary, P.; De Bock, M.; Elbarbary, N.; Forlenza, G.; Gomez, A.M.; Grassi Corrales, Bruno; Mader, J.; O'Neal, D.; Schwarz, P.
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    A clinical teaching course for residents improves self-perception about preparation to teach
    (SOC MEDICA SANTIAGO, 2012) Reyes, Carlos; Florenzano, Pablo; Contreras, Alvaro; Gonzalez, Alejandro; Beltran, Daniela; Aravena, Carlos; Grassi Corrales, Bruno
    A clinical teaching course for residents improves self-perception about preparation to teach Background: Medical doctors need to be competent to teach patients, their families, students, and the health care team. In a previous study we determined that although the residents attach great importance to have teaching skills, they do not feel prepared to meet this role. Aim: To assess self-perception of learning in a formal course of training how to teach for residents. Material and Methods: In 2004 we implemented the course "Residents as Clinical Teachers", based on the Stanford Faculty Development Center for Medical Teachers Model (SFDC), for residents of a Medical School. Residents of all the post graduate programs were invited to take the course as an elective during the period 2004-2011. At the end of the course each resident completed the pre/post Seminar Series Housestaff/student Questionnaire; assessing perceptions of learning, expressed in a Likert scale from 1-5. Results: The implementation of the course in 111 residents significantly improved self-perception of general preparation for teaching and improved self-perception of preparedness in each educational category. The personal goals most commonly established by participants were on feedback (52,2%), control of session (44%) and communication of goals (40%). Barriers for teaching most frequently identified were lack of time to do clinical teaching (51,3%) and environmental limitations (16,2%). The main impact of the course reported by residents were acquisition of teaching skills or tools for teaching (39,6%), enhancing of motivation (14%), and a richer understanding of teaching principles (14%). Conclusions: A clinical teaching course for residents improves their self-perception of preparation to teach and enhances motivation for clinical teaching. (Rev Med Chile 2012; 140: 1431-1436).
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    Cetoacidosis diabética : Casuística 2008-2012, epidemiología y fisiopatología
    (2014) Olmos Coelho, Pablo Roberto; Donoso Henríquez, Aníbal Tomás; Arab Verdugo, Juan Pablo; Niklitschek, I.; Mertens, N.; Arce, E.; Lemus, R.; Serrano Larrea, Valentina; Grassi Corrales, Bruno; Strodthoff Simunovic, Kristel; Abbott Cáceres, Eduardo Francisco; Aizman, Andrés; González, M.
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    Determination of time in range associated with HbA1c <= 6.5% in Latin American pregnant women diagnosed with type 1 diabetes mellitus using an automated insulin delivery system
    (ELSEVIER IRELAND LTD, 2023) Medina, Ana Maria Gomez; Chavez, Maria Juliana Soto; Carrillo, Diana Cristina Henao; Sanchez, Juan Camilo Salgado; Gonzalez, Javier Alberto Gomez; Grassi Corrales, Bruno; Velandia, Oscar Mauricio Munoz
    Aims: To determine the correlation between %TIR and HbA1c in pregnant women with type 1 diabetes mellitus (DM1)., Methods: Diagnostic test study in a prospective cohort of pregnant patients with DM1 using automated insulin delivery system (AID) in Colombia and Chile., Results: Fifty-two patients were included [mean age 31.8 +/- 6.2 years, pregestational HbA1c 7.2% [interquartile range (IQR), 6.5-8.2]. During follow-up, we found a better metabolic control during the second (HbA1c 6.40%, IQR 5.9,7.1) and third trimesters (HbA1c 6.25%;IQR 5.9,6.8). A weak and negative correlation between %TIR and HbA1c was found for all the gestation (Spearman's rank correlation coefficient:-0.22, p:0.0329), and in the second (r:-0.13, p: 0.38) and third trimesters (r:-0.26, p = 0.08). %TIR had poor discriminating capacity for predicting HbA1c < 6% (area under the curve [AUC], 0.59; 95% confidence interval [CI],0.46-0.72) and for predicting HbA1c < 6.5% (AUC, 0.57;95% CI,0.44-0.70). The optimal cutoff points for %TIR were > 66.1% for predicting HbA1c < 6% (65% sensitivity, 62% specificity) and %TIR > 61.1% for HbA1c < 6.5% (59% sensitivity, 54% specificity)., Conclusion: The correlation between HbA1c and %TIR during pregnancy was weak. The optimal cutoff points for identifying patients with HbA1c < 6.0% and < 6.5% were %TIR > 66.1% and > 61.1%, respectively, with moderate sensitivity and specificity.
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    Diagnóstico de la infección por Treponema pallidum en pacientes con sífilis temprana y neurosífilis mediante reacción de la polimerasa en cadena
    (2011) García Cañete, Patricia; Grassi Corrales, Bruno; Fich, Félix; Salvo Lizama, Aurelio Fernando; Araya, Luis; Abarzúa C., Fernando; Soto, Julia; Poggi, Helena; Lagos L., Marcela; Vásquez T., Patricia; Leon C., Eugenia; Pérez C., Carlos; Wozniak Banchero, Aniela
    La sífilis es una enfermedad de transmisión sexual producida por Treponema pallidum, cuyo diagnóstico se realiza presuntivamente basándose en aspectos clínicos y análisis de especificidad limitada. La reacción de la polimerasa en cadena (RPC) ha sido planteada como una alternativa diagnóstica de mayor sensibilidad y especificidad. El objetivo de este trabajo fue validar una RPC para el diagnóstico de sífilis temprana (ST) y neurosífilis (NS). Se utilizaron muestras de lesiones muco-cutáneas y de LCR de pacientes con sospecha de cursar ST y NS respectivamente, previamente diagnosticados, utilizando un estándar de oro ampliado. La RPC fue realizada con partidores dirigidos al gen tpN47. De las 21 muestras de pacientes con ST, la RPC resultó positiva en 20, lo que resulta en una sensibilidad clínica de 95%. De las 8 muestras de pacientes con NS, la RPC resultó positiva en 4, obteniéndose una sensibilidad clínica de 50%. La especificidad clínica para ST y NS fue de 100%. La excelente sensibilidad y especificidad de la RPC para muestras muco-cutáneas permitió la exitosa implementación de este análisis en nuestro laboratorio para el diagnóstico de rutina. Si bien la sensibilidad de la RPC en LCR es baja, es muy útil para apoyar el diagnóstico clínico
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    ¿Disminuye el riesgo cardiovascular al agregar ezetimibe al tratamiento con estatinas?
    (2016) Araya, Francisca I.; Grassi Corrales, Bruno
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    Lower versus standard sucrose dose for treating hypoglycemia in patients with type 1 diabetes mellitus in therapy with predictive low glucose suspend (PLGS) augmented insulin pumps: A randomized crossover trial in Santiago, Chile
    (ELSEVIER SCI LTD, 2021) Grassi Corrales, Bruno; Onetto Flores, María Teresa; Zapata Olivares, Yazmin Alejandra; Jofre Mendoza, Paulina Eugenia; Echeverria Errazuriz, Guadalupe
    Background and aims: Recommended hypoglycemia treatment in adults with T1D consists of 15 g of rapid absorption carbohydrates. We aimed to evaluate the response to fewer carbohydrates for treating hypoglycemia in patients with T1D on insulin pumps with predictive suspension technology (PLGS).
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    New Mechanisms to Prevent Heart Failure with Preserved Ejection Fraction Using Glucagon-like Peptide-1 Receptor Agonism (GLP-1 RA) in Metabolic Syndrome and in Type 2 Diabetes: A Review
    (2024) Jalil Milad, Jorge Emilio; Gabrielli Nervi, Luigi Arnaldo; Ocaranza Jeraldino, María Paz; MacNab, P.; Fernandez R.; Grassi Corrales, Bruno; Jofré Mendoza, Paulina Eugenia; Verdejo, H.; Acevedo, M.; Cordova Alvestegui, Samuel Edmundo; Sanhueza, Luis; Greig Undurraga, Douglas Patrick
    This review examines the impact of obesity on the pathophysiology of heart failure with preserved ejection fraction (HFpEF) and focuses on novel mechanisms for HFpEF prevention using a glucagon-like peptide-1 receptor agonism (GLP-1 RA). Obesity can lead to HFpEF through various mechanisms, including low-grade systemic inflammation, adipocyte dysfunction, accumulation of visceral adipose tissue, and increased pericardial/epicardial adipose tissue (contributing to an increase in myocardial fat content and interstitial fibrosis). Glucagon-like peptide 1 (GLP-1) is an incretin hormone that is released from the enteroendocrine L-cells in the gut. GLP-1 reduces blood glucose levels by stimulating insulin synthesis, suppressing islet α-cell function, and promoting the proliferation and differentiation of β-cells. GLP-1 regulates gastric emptying and appetite, and GLP-1 RA is currently indicated for treating type 2 diabetes (T2D), obesity, and metabolic syndrome (MS). Recent evidence indicates that GLP-1 RA may play a significant role in preventing HFpEF in patients with obesity, MS, or obese T2D. This effect may be due to activating cardioprotective mechanisms (the endogenous counter-regulatory renin angiotensin system and the AMPK/mTOR pathway) and by inhibiting deleterious remodeling mechanisms (the PKA/RhoA/ROCK pathway, aldosterone levels, and microinflammation). However, there is still a need for further research to validate the impact of these mechanisms on humans.
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    The mediterranean diet, hepatic steatosis and nonalcoholic fatty liver disease
    (2014) Velasco Fuentes, Nicolas; Contreras Sepúlveda, Alvaro Javier; Grassi Corrales, Bruno
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    Tratamiento de quilotórax y quiloascitis refractaria en paciente cirrótico : caso clínico
    (2020) Jofré, P.; Grassi Corrales, Bruno; Benítez Gajardo, Carlos Esteban