Browsing by Author "Granger, CB"
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- ItemAssociation of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes(MOSBY, INC, 2004) McGuire, DK; Newby, LK; Bhapkar, MV; Moliterno, DJ; Hochman, JS; Klein, WW; Weaver, WD; Pfisterer, M; Corbalan, R; Dellborg, M; Granger, CB; Van de Werf, F; Topol, EJ; Califf, RM; SYMPHONY and 2nd SYMPHONY InvestigatorsBackground Diabetes is associated with an increased risk for coronary artery disease (CAD) and its complications. The relative effect of glucose-lowering strategies of "insulin provision" versus "insulin sensitization" among patients with CAD remains unclear.
- ItemDisagreements between central clinical events committee and site investigator assessments of myocardial infarction endpoints in an international clinical trial: review of the PURSUIT study(2001) Mahaffey, KW; Harrington, RA; Akkerhuis, M; Kleiman, NS; Berdan, LG; Crenshaw, BS; Tardiff, BE; Granger, CB; DeJong, I; Bhapkar, M; Widimsky, P; Corbalon, R; Lee, KL; Deckers, JW; Simoons, ML; Topol, EJ; Califf, RMBackground Limited information has been published regarding how specific processes for event adjudication can affect event rates in trials. We reviewed nonfatal myocardial infarctions (MIs) reported by site investigators in the international Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin (Eptifibatide) Therapy (PURSUIT) trial and those adjudicated by a central clinical events committee (CEC) to determine the reasons for differences in event rates.