Browsing by Author "Gonzalez L."

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    Enhanced Peripheral Chemoreflex Drive Is Associated with Cardiorespiratory Disorders in Mice with Coronary Heart Disease
    (Springer, 2023) Bravo L.; Pereyra K.V.; Diaz H.S.; Flores M.; Schwarz K.G.; Toledo C.; Diaz-Jara E.; Gonzalez L.; Andia M.E.; Del Rio R.; CEDEUS (Chile)
    © 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.Coronary heart disease (CHD) is a prevalent cardiovascular disease characterized by coronary artery blood flow reductions caused by lipid deposition and oxidation within the coronary arteries. Dyslipidemia is associated with local tissue damage by oxidative stress/inflammation and carotid bodies (CB) peripheral chemoreceptors are heavily modulated by both reactive oxygen species and pro-inflammatory molecules (i.e., cytokines). Despite this, it is not know whether CB-mediated chemoreflex drive may be affected in CHD. In the present study, we evaluated peripheral CB-mediated chemoreflex drive, cardiac autonomic function, and the incidence of breathing disorders in a murine model of CHD. Compared to age-matched control mice, CHD mice showed enhanced CB-chemoreflex drive (twofold increase in the hypoxic ventilatory response), cardiac sympathoexcitation, and irregular breathing disorders. Remarkably, all these were closely linked to the enhanced CB-mediated chemoreflex drive. Our results showed that mice with CHD displayed an enhanced CB chemoreflex, sympathoexcitation, and disordered breathing and suggest that CBs may be involved in chronic cardiorespiratory alterations in the setting of CHD.
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    Planning for accessibility: the divide between research and policy in the promotion of equitable mobility
    (SPRINGER INTERNATIONAL PUBLISHING AG, 2023) Tiznado Aitken I.; Vecchio G.; Mora R.; Gonzalez L.; Marshall C.; CEDEUS (Chile)
    © 2023 Regional Studies Association.Mobility-related social inequalities are receiving increasing attention from planning research and practice. Nevertheless, research seems to have a limited impact on urban policies addressing mobility. Using Santiago de Chile as a case study, the paper discusses the existing gaps between research on mobility-related equity concerns and existing policies and plans addressing urban mobility operating at national, metropolitan and municipal scales. An equity-based comparison is performed for different spatial planning instruments, exploring guiding concepts and deriving proposals through content analysis. The findings show that there is a comprehensive and multidisciplinary body of literature in Santiago on mobility and equity, approaching several dimensions of mobility, accessibility and social exclusion in relation to different population groups. However, the series of discourses, norms and actions (policies and programmes) operating at different planning scales lack coherence and address only some of the dimensions identified in the literature. Current plans and policies in Santiago have a limited scope and are difficult to modify, questioning their effectiveness for understanding and tackling mobility-related equity concerns.