Browsing by Author "Gonzalez, Javier"

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    A Quinoa Protein Hydrolysate Fractionated by Electrodialysis with Ultrafiltration Membranes Improves Maternal and Fetal Outcomes in a Mouse Model of Gestational Diabetes Mellitus
    (2023) Busso, Dolores; Gonzalez, Adrian; Santander, Nicolas; Saavedra, Fujiko; Quiroz, Alonso; Rivera, Katherine; Gonzalez, Javier; Olmos, Pablo; Marette, Andre; Bazinet, Laurent; Illanes, Sebastian; Enrione, Javier
    ScopeQuinoa intake exerts hypoglycemic and hypolipidemic effects in animals and humans. Although peptides from quinoa inhibit key enzymes involved in glucose homeostasis in vitro, their in vivo antidiabetic properties have not been investigated.Methods and resultsThis study evaluated the effect of oral administration of a quinoa protein hydrolysate (QH) produced through enzymatic hydrolysis and fractionation by electrodialysis with ultrafiltration membrane (EDUF) (FQH) on the metabolic and pregnancy outcomes of Lepdb/+ pregnant mice, a preclinical model of gestational diabetes mellitus. The 4-week pregestational consumption of 2.5 mg mL-1 of QH in water prevented glucose intolerance and improves hepatic insulin signaling in dams, also reducing fetal weights. Sequencing and bioinformatic analyses of the defatted FQH (FQHD) identified 11 peptides 6-10 amino acids long that aligned with the quinoa proteome and exhibited putative anti-dipeptidyl peptidase-4 (DPP-IV) activity, confirmed in vitro in QH, FQH, and FDQH fractions. Peptides homologous to mouse and human proteins enriched for biological processes related to glucose metabolism are also identified.ConclusionProcessing of quinoa protein may be used to develop a safe and effective nutritional intervention to control glucose intolerance during pregnancy. Further studies are required to confirm if this nutritional intervention is applicable to pregnant women.
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    Función atenuante de las formas verbales que expresan duda en entrevistas semidirigidas del corpus PRESEEA de Chile
    (2023) Gajardo, Consuelo; Guerrero, Silvana; Ibarra, Daniela; Gonzalez, Javier; Universidad de Antioquía
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    Función atenuante de las formas verbales que expresan duda en entrevistas semidirigidas del corpus PRESEEA de Chile
    (2023) Gajardo Moller, Consuelo; Guerrero, Silvana; Ibarra, Daniela; Gonzalez, Javier; Universidad de Antioquía
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    The association between vegetation size and surgical treatment on 6-month mortality in left-sided infective endocarditis
    (2019) Fosbol, Emil L.; Park, Lawrence P.; Chu, Vivian H.; Athan, Eugene; Delahaye, Francois; Freiberger, Tomas; Lamas, Cristiane; Miro, Jose M.; Strahilevitz, Jacob; Tribouilloy, Christophe; Durante-Mangoni, Emanuele; Pericas, Juan M.; Fernandez-Hidalgo, Nuria; Nacinovich, Francisco; Rizk, Hussein; Barsic, Bruno; Giannitsioti, Efthymia; Hurley, John P.; Hannan, Margaret M.; Wang, Andrew; Clara, Liliana; Sanchez, Marisa; Casabe, Jose; Nacinovich, Francisco; Oses, Pablo Fernandez; Ronderos, Ricardo; Sucari, Adriana; Thierer, Jorge; Altclas, Javier; Kogan, Silvia; Spelman, Denis; Athan, Eugene; Harris, Owen; Kennedy, Karina; Tan, Ren; Gordon, David; Papanicolas, Lito; Korman, Tony; Kotsanas, Despina; Dever, Robyn; Jones, Phillip; Konecny, Pam; Lawrence, Richard; Rees, David; Ryan, Suzanne; Feneley, Michael P.; Harkness, John; Jones, Phillip; Ryan, Suzanne; Jones, Phillip; Ryan, Suzanne; Jones, Phillip; Post, Jeffrey; Reinbott, Porl; Ryan, Suzanne; Gattringer, Rainer; Wiesbauer, Franz; Andrade, Adriana Ribas; Passos de Brito, Ana Claudia; Guimaraes, Armenio Costa; Grinberg, Max; Mansur, Alfredo Jose; Siciliano, Rinaldo Focaccia; Varejao Strabelli, Tania Mara; Campos Vieira, Marcelo Luiz; de Medeiros Tranchesi, Regina Aparecida; Paiva, Marcelo Goulart; Fortes, Claudio Querido; Ramos, Auristela de Oliveira; Weksler, Clara; Ferraiuoli, Giovanna; Golebiovski, Wilma; Lamas, Cristiane; Karlowsky, Canada James A.; Keynan, Yoav; Morris, Andrew M.; Rubinstein, Ethan; Jones, Sandra Braun; Garcia, Patricia; Cereceda, M.; Fica, Alberto; Mella, Rodrigo Montagna; Fernandez, Ricardo; Franco, Liliana; Gonzalez, Javier; Jaramillo, Astrid Natalia; Barsic, Bruno; Bukovski, Suzana; Krajinovic, Vladimir; Pangercic, Ana; Rudez, Igor; Vincelj, Josip; Freiberger, Tomas; Pol, Jiri; Zaloudikova, Barbora; Ashour, Zainab; El Kholy, Amani; Mishaal, Marwa; Osama, Dina; Rizk, Hussien; Aissa, Neijla; Alauzet, Corentine; Alla, Francois; Campagnac, Catherine; Doco-Lecompte, Thanh; Selton-Suty, Christine; Casalta, Jean-Paul; Fournier, Pierre-Edouard; Habib, Gilbert; Raoult, Didier; Thuny, Franck; Delahaye, Francois; Delahaye, Armelle; Vandenesch, Francois; Donal, Erwan; Donnio, Pierre Yves; Flecher, Erwan; Michelet, Christian; Revest, Matthieu; Tattevin, Pierre; Chevalier, Florent; Jeu, Antoine; Remadi, Jean Paul; Rusinaru, Dan; Tribouilloy, Christophe; Bernard, Yvette; Chirouze, Catherine; Hoen, Bruno; Leroy, Joel; Plesiat, Patrick; Naber, Christoph; Neuerburg, Carl; Mazaheri, Bahram; Naber, Christoph; Athanasia, Sophia; Deliolanis, Ioannis; Giamarellou, Helen; Thomas, Tsaganos; Giannitsioti, Efthymia; Mylona, Elena; Paniara, Olga; Papanicolaou, Konstantinos; Pyros, John; Skoutelis, Athanasios; Mylona, Elena; Paniara, Olga; Papanikolaou, Konstantinos; Pyros, John; Skoutelis, Athanasios; Sharma, Gautam; Francis, Johnson; Nair, Lathi; Thomas, Vinod; Venugopal, Krishnan; Hannan, Margaret M.; Hurley, John P.; Cahan, Amos; Gilon, Dan; Israel, Sarah; Korem, Maya; Strahilevitz, Jacob; Rubinstein, Ethan; Strahilevitz, Jacob; Durante-Mangoni, Emanuele; Mattucci, Irene; Pinto, Daniela; Agrusta, Federica; Senese, Alessandra; Ragone, Enrico; Utili, Riccardo; Cecchi, Enrico; De Rosa, Francesco; Forno, Davide; Imazio, Massimo; Trinchero, Rita; Grossi, Paolo; Lattanzio, Mariangela; Toniolo, Antonio; Goglio, Antonio; Raglio, Annibale; Ravasio, Veronica; Rizzi, Marco; Suter, Fredy; Carosi, Giampiero; Magri, Silvia; Signorini, Liana; Kanafani, Zeina; Kanj, Souha S.; Sharif-Yakan, Ahmad; Abidin, Imran; Tamin, Syahidah Syed; Rivera Martinez, Eduardo; Soto Nieto, Gabriel Israel; van der Meer, Jan T. M.; Chambers, Stephen; Holland, David; Morris, Arthur; Raymond, Nigel; Read, Kerry; Murdoch, David R.; Dragulescu, Stefan; Ionac, Adina; Mornos, Cristian; Butkevich, O. M.; Chipigina, Natalia; Kirill, Ozerecky; Vadim, Kulichenko; Vinogradova, Tatiana; Edathodu, Jameela; Halim, Magid; Liew, Yee-Yun; Tan, Ru-San; Lejko-Zupanc, Tatjana; Logar, Mateja; Mueller-Premru, Manica; Commerford, Patrick; Commerford, Anita; Deetlefs, Eduan; Hansa, Cass; Ntsekhe, Mpiko; Almela, Manuel; Armero, Yolanda; Azqueta, Manuel; Castaneda, Ximena; Cervera, Carlos; Falces, Carlos; Garcia de-la-Maria, Cristina; Fita, Guillermina; Gatell, Jose M.; Heras, Magda; Llopis, Jaime; Marco, Francesc; Mestres, Carlos A.; Miro, Jose M.; Moreno, Asuncion; Ninot, Salvador; Pare, Carlos; Pericas, Juan M.; Ramirez, Jose; Rovira, Irene; Sitges, Marta; Anguera, Ignasi; Font, Bernat; Guma, Joan Raimon; Bermejo, Javier; Bouza, Emilio; Garcia Fernandez, Miguel Angel; Gonzalez-Ramallo, Victor; Marin, Mercedes; Munoz, Patricia; Pedromingo, Miguel; Roda, Jorge; Rodriguez-Creixems, Marta; Solis, Jorge; Almirante, Benito; Fernandez-Hidalgo, Nuria; Tornos, Pilar; de Alarcon, Aristides; Parra, Ricardo; Alestig, Eric; Johansson, Magnus; Olaison, Lars; Snygg-Martin, Ulrika; Pachirat, Orathai; Pachirat, Pimchitra; Pussadhamma, Burabha; Senthong, Vichai; Casey, Anna; Elliott, Tom; Lambert, Peter; Watkin, Richard; Eyton, Christina; Klein, John L.; Bradley, Suzanne; Kauffman, Carol; Bedimo, Roger; Chu, Vivian H.; Corey, G. Ralph; Crowley, Anna Lisa; Douglas, Pamela; Drew, Laura; Fowler, Vance G.; Holland, Thomas; Lalani, Tahaniyat; Mudrick, Daniel; Samad, Zaniab; Sexton, Daniel; Stryjewski, Martin; Woods, Christopher W.; Lerakis, Stamatios; Cantey, Robert; Steed, Lisa; Wray, Dannah; Dickerman, Stuart A.; Bonilla, Hector; DiPersio, Joseph; Salstrom, Sara-Jane; Baddley, John; Patel, Mukesh; Peterson, Gail; Stancoven, Amy; Levine, Donald; Riddle, Jonathan; Rybak, Michael
    Aims In left-sided infective endocarditis (IE), a large vegetation >10mm is associated with higher mortality, yet it is unknown whether surgery during the acute phase opposed to medical therapy is associated with improved survival. We assessed the association between surgery and 6-month mortality as related to vegetation size.
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    Vitamin E supplementation prevents obesogenic diet-induced developmental abnormalities in SR-B1 deficient embryos
    (2024) Quiroz, Alonso; Belledonne, Gabriela; Saavedra, Fujiko; Gonzalez, Javier; Busso, Dolores
    Introduction Genetic and environmental factors influence the risk of neural tube defects (NTD), congenital malformations characterized by abnormal brain and spine formation. Mouse embryos deficient in Scavenger Receptor Class B Type 1 (SR-B1), which is involved in the bidirectional transfer of lipids between lipoproteins and cells, exhibit a high prevalence of exencephaly, preventable by maternal vitamin E supplementation. SR-B1 knock-out (KO) embryos are severely deficient in vitamin E and show elevated reactive oxygen species levels during neurulation.Methods We fed SR-B1 heterozygous female mice a high-fat/high-sugar (HFHS) diet and evaluated the vitamin E and oxidative status in dams and embryos from heterozygous intercrosses. We also determined the incidence of NTD.Results and discussion HFHS-fed SR-B1 HET females exhibited altered glucose metabolism and excess circulating lipids, along with a higher incidence of embryos with developmental delay and NTD. Vitamin E supplementation partially mitigated HFHS-induced maternal metabolic abnormalities and completely prevented embryonic malformations, likely through indirect mechanisms involving the reduction of oxidative stress and improved lipid handling by the parietal yolk sac.