Browsing by Author "González Muñoz, Pablo Alberto"
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- ItemDifferential Severe Acute Respiratory Syndrome Coronavirus 2-Specific Humoral Response in Inactivated Virus-Vaccinated, Convalescent, and Breakthrough-Infected Subjects(OXFORD UNIV PRESS INC, 2023) Duarte Peñaloza, Luisa Fernanda; Vazquez Hernandez Yaneisi; Diethelm Varela, Benjamin Manuel; Pavez, Valentina; Berrios-Rojas, Roslye; Riedel, Claudia A.; Mendez, Constanza; White, Jessica A.; Kalergis Parra, Alexis Mikes; Bueno Ramírez, Susan Marcela; González Muñoz, Pablo AlbertoBackground. We sought to identify potential antigens for discerning between humoral responses elicited after vaccination with CoronaVac (a severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] inactivated vaccine), natural infection, or breakthrough infection., Methods. Serum samples obtained from volunteers immunized with CoronaVac (2 and 3 doses), breakthrough case patients, and from convalescent individuals were analyzed to determine the immunoglobulin (Ig) G responses against 3 structural and 8 nonstructural SARS-CoV-2 antigens., Results. Immunization with CoronaVac induced higher levels of antibodies against the viral membrane (M) protein compared with convalescent subjects both after primary vaccination and after a booster dose. Individuals receiving a booster dose displayed equivalent levels of IgG antibodies against the nucleocapsid (N) protein, similar to convalescent subjects. Breakthrough case patients produced the highest antibody levels against the N and M proteins. Antibodies against nonstructural viral proteins were present in >50% of the convalescent subjects., Conclusions. Vaccinated individuals elicited a different humoral response compared to convalescent subjects. The analysis of particular SARS-CoV-2 antigens could be used as biomarkers for determining infection in subjects previously vaccinated with CoronaVac.
- ItemFormulación inmunogénica que confiere protección contra la infección o patología causada por el virus respiratorio sincicial (VRS) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulación inmunogénica para preparar una vacuna para prevenir, tratar o atenuar infecciones del VRS (Austria, concesión n° EP2207567)Kalergis Parra, Alexis Mikes; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan
- ItemFormulación inmunogénica que confiere protección contra la infección o patología causada por el virus respiratorio sincicial (VRS) que comprende una cepa recombinante atenuada de mycobacterium; y uso de la formulación inmunogénica para preparar una vacuna para prevenir, tratar o atenuar infecciones del VRS (Lituania, concesión n° EP2207567)Kalergis Parra, Alexis Mikes; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan
- ItemHerpes simplex virus 2 infection: molecular association with HIV and novel microbicides to prevent disease.(2015) Suazo, P. A.; Tognarelli Torres, Eduardo Ignacio; Kalergis Parra, Alexis Mikes; González Muñoz, Pablo Alberto
- ItemHuman metapneumovirus keeps dendritic cells from priming antigen-specific naive T cells(2013) Céspedes Donoso, Pablo Francisco; González Muñoz, Pablo Alberto; Kalergis Parra, Alexis Mikes
- ItemHuman Respiratory Syncytial Virus: Infection and Pathology(2016) Bohmwald Prieto, Karen; Espinoza Véliz, Janyra Alejandra; Rey Jurado, Emma; Gómez Johnson, Roberto Sebastian; González Muñoz, Pablo Alberto; Bueno Ramírez, Susan; Riedel, Claudia A.; Kalergis Parra, Alexis MikesThe human respiratory syncytial virus (hRSV) is by far the major cause of acute lower respiratory tract infections (ALRTIs) worldwide in infants and children younger than 2 years. The overwhelming number of hospitalizations due to hRSV-induced ALRTI each year is due, at least in part, to the lack of licensed vaccines against this virus. Thus, hRSV infection is considered a major public health problem and economic burden in most countries. The lung pathology developed in hRSV-infected individuals is characterized by an exacerbated proinflammatory and unbalanced Th2-type immune response. In addition to the adverse effects in airway tissues, hRSV infection can also cause neurologic manifestations in the host, such as seizures and encephalopathy. Although the origins of these extrapulmonary symptoms remain unclear, studies with patients suffering from neurological alterations suggest an involvement of the inflammatory response against hRSV. Furthermore, hRSV has evolved numerous mechanisms to modulate and evade the immune response in the host. Several studies have focused on elucidating the interactions between hRSV virulence factors and the host immune system, to rationally design new vaccines and therapies against this virus. Here, we discuss about the infection, pathology, and immune response triggered by hRSV in the host.
- ItemLung pathology due to hRSV infection impairs blood–brain barrier permeability enabling astrocyte infection and a long-lasting inflammation in the CNS(2021) Bohmwald Prieto, Karen; Soto Ramírez, Jorge Andrés; Andrade Parra, Catalina Andrea; Fernández Fierro, Ayleen Lorena; Espinoza Véliz, Janyra Alejandra; Rios Raggio, Mariana; Eugenin, E. A.; González Muñoz, Pablo Alberto; Opazo, M. C.; Kalergis Parra, Alexis Mikes
- ItemNovel therapies and vaccines against the human respiratory syncytial virus(2015) Rivera, C.; Gómez Johnson, Roberto Sebastian; Díaz Montero, Rodrigo Aquiles; Céspedes, P.; Espinoza Véliz, Janyra Alejandra; González Muñoz, Pablo Alberto; Riedel, C.; Bueno Ramírez, Susan; Kalergis Parra, Alexis Mikes
- ItemPharmacological Induction of Heme Oxygenase-1 Impairs Nuclear Accumulation of Herpes Simplex Virus Capsids upon Infection(2017) Ibáñez, Francisco J.; Farías, Mónica A.; Retamal Díaz, Angello Ricardo; Espinoza Véliz, Janyra Alejandra; Kalergis Parra, Alexis Mikes; González Muñoz, Pablo Alberto
- ItemTackling cutaneous herpes simplex virus disease with topical immunomodulators—a call to action(2025) Duarte, Luisa F.; Carbone Schellman, Javier; Bueno Ramírez, Susan Marcela; Kalergis Parra, Alexis Mikes; Riedel, Claudia A.; González Muñoz, Pablo Alberto