Browsing by Author "González Bombardiere, Sergio Javier"
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- ItemCholesterol saturation, not proteins or cholecystitis, is critical for crystal formation in human gallbladder bile(W. B. Saunders Co., 1998) Miquel Poblete Juan Francisco; Nuñez, Liliana; Amigo Boker, Ludwig Peter; González Bombardiere, Sergio Javier; Raddatz Echavarría, Alejandro; Rigotti Rivera, Attilio Gianpietro; Nervi Oddone, FlavioBiliary proteins are promoters of cholesterol crystallization in artificial model bile. However, their pathogenic importance for cholesterol precipitation in native gallbladder bile (GB) is uncertain. The aim of this study was to evaluate the significance of biliary lipids and proteins on cholesterol crystal detection time (ChCDT) of GB in patients with gallstones. Methods: ChCDT and concentrations of lipids, albumin, mucins, aminopeptidase N, alpha 1-acid glycoprotein, haptoglobin, and immunoglobulins (Igs) were measured in GB of 92 patients, 52 of whom had cholesterol gallstones. Results: ChCDT was markedly reduced in gallstone patients. Compared with patients without gallstones, they had a significant increase in cholesterol saturation and total protein, albumin, mucin, and IgG biliary concentrations. In univariate analysis, ChCDT of GB was significantly correlated with cholesterol saturation and total lipid, protein, Ig, aminopeptidase N, and alpha 1-acid glycoprotein concentrations. However, stepwise logistic regression analysis showed that only cholesterol saturation independently correlated to ChCDT. Gallbladder inflammation correlated with the concentration of Igs, but subtraction of IgG from GB did not modify the ChCDT. Conclusions: Biliary cholesterol transport and saturation, but not proteins, appear critical for the cholesterol crystallization abnormality observed in native bile from patients with gallstones.
- ItemColagenosis perforante reactiva adquirida. Caso clínico(Sociedad Médica Santiago, 2010) Cárdenas de la Torre, Consuelo Paz; Bello Cisternas, Cristina del Carmen; Uribe González, Pablo Francisco; Romero Gallardo Williams Andres; González Bombardiere, Sergio JavierAcquired reactive perforating collagenosis is a perforating dermatosis characterized by transepidermal elimination of collagen. It is frequently associated to diabetes mellitus and chronic renal insufficiency, but it is also related to other systemic diseases. The lesions tend to resolve once the underlying condition is treated. We report two patients with the condition. A 65 year-old diabetic female on hemodialysis consulted for multiple itching cutaneous ulcers lasting one year. On physical examination, hyperpigmented papules and nodules were observed. A 65 year-old female with chronic renal failure in hemodialysis consulted for itching lesions in hands, forearms and arms. On physical examination, hyperpigmented lesions with ulcers, erosions and crusts were observed. In both cases, the pathological study of the lesions disclosed a reactive perforating collagenosis. (Rev Med Chile 2010; 138: 1281-1284).