Browsing by Author "González Agüero, Marcela Margot"

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    Búsqueda de mutaciones en el gen UL 97 asociadas a resistencia a ganciclovir en citomegalovirus obtenidos desde muestras biológicas de pacientes chilenos
    (2010) Oyarzún Andrade, María Angélica; Bustos, Patricia; González Agüero, Marcela Margot; Domínguez Moreno, María Isabel; Aguayo González, Francisco Renan; Nervi Nattero, Bruno; Ferrés, Marcela
    Background: Long term use of ganciclovir (GCV) is associated with acquired resistance to it. Ninety percent of the responsible mutations occur in cytomegalovirus (CMV) UL97 gene. Aim: To search for these mutations, comparing nucleotide sequences of CMV-positive samples from post transplant and immunocompromised patients receiving GCV, with sequences of CMV isolates obtained from subjects not exposed to the drug. Patients and Methods: Codons 440 to 465 of gene UL97, including the most common mutations causing resistance to GCV, were amplified in 33 plasma samples from patients exposed to GCV and in 15 urine samples of newborns. Both populations and their nucleotide sequences were compared with the prototype strain CMV AD169. Results: Samples of exposed patients had multiple mutations but only one had a mutation associated with clinical resistance (M4601). Eight subjects had the D605E mutation, whose role in resistance is controversial. The remaining 150 mutations were silent mutations. Conclusions: A low frequency of mutations associated with CMV resistance to GCV was found in these exposed and unexposed samples. These mutations may reflect coexistence of multiple genetic variants of CMV. The absence of clinical expression of resistance, even with these mutations, can be explained by the use of GCV for a shorter lapse than that associated with the appearance of resistance. (Rev Med Chile 2010; 138: 421-427).
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    Las infancias invisibilizadas: desafíos de los datos estadísticos e indicadores biopsicosociales de niños y niñas indígenas y migrantes
    (2024) Martínez Santana, Dayann Carolina; Alcayaga Rojas, Claudia Andrea; Farías Cancino, Angélica Margarita; Márquez Doren, Francisca; Lucchini Raies, Camila; González Agüero, Marcela Margot; Bustamante Troncoso, Claudia Raquel; Centro de Políticas Públicas UC (Chile)
    Todos los niños y niñas tienen el derecho a disfrutar de una vida saludable, en donde se desarrollen seguros, protegidos y puedan recibir servicios sociales de salud y educación que les permita acceder a oportunidades básicas para tener una trayectoria de vida productiva y próspera. Sin embargo, se ha observado que niños y niñas indígenas y migrantes durante su primera infancia están expuestos a mayores desigualdades sociales.Este artículo tiene como objetivo analizar críticamente las fuentes de datos estadísticos e indicadores de salud biopsicosocial de las infancias indígenas y migrantes en Chile, y analizar su impacto en la formulación y ejecución de políticas públicas de salud.
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    Psychosocial and vulnerability factors affecting well-being of migrant mothers from Latin America: A scoping review
    (2025) Díaz Melgarejo, Oliva; Cárdenas Sánchez, María Elvira; Grau Rengifo, María Olaya; Berríos-Riquelme, José; Bernales, Margarita; Bolívar Fernández, Daniela; González Agüero, Marcela Margot; Grau Rengifo, María Florencia
    This scoping review examines the experiences of migrant mothers from Latin America, highlighting psychosocial and vulnerability factors affecting their well-being in migration contexts. Focusing on south-to-south migration and the gendered experiences of caregiving women, it addresses a significant gap in the literature. Findings reveal unique challenges such as acculturation stress, economic hardships, limited social support, and mental health issues exacerbated by marginalization due to caregiving roles. Practice implications for social work and policy include culturally competent interventions and the design of supportive policies tailored to migrant mothers’ needs.
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    What makes a health movement successful? Health inequalities and the insulin pump in Chile
    (2020) González Agüero, Marcela Margot; Vargas Celis, Ivonne; Campos Romero, Solange; Farías Cancino, Angélica; Quezada Quezada, C.; Urrutia Egaña, Marcela Javiera