Browsing by Author "Gomez, R."
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- ItemAssociation of the estrogen receptor α gene polymorphisms with osteoporosis in the Mexican population(2007) Gomez, R.; Magana, J. J.; Cisneros, B.; Perez-Salazar, E.; Faugeron, S.; Veliz, D.; Castro, C.; Rubio, J.; Casas, L.; Valdes-Flores, MargaritaThe estrogen receptor gene (ER alpha) has been implicated in the development of osteoporosis. In this study, the association of two ER alpha gene polymorphic markers (a TA dinucleotide repeat and a single nucleotide polymorphism, G2014A) with osteoporosis was tested in 70 osteoporotic women, 70 non-osteoporotic women and 500 subjects from the Mexican population. According to the genetic analysis of the Mexican population using eight unlinked polymorphic markers, we found that our population is structured into three subpopulations; therefore, the allele-phenotype relationship was analyzed with a statistical method that considered population stratification. We found that the G2014A polymorphism is associated with the presence of osteoporosis while the TA dinucleotide repeat is not. The G allele and the GG genotype frequencies of the G2014A marker were significantly higher in osteoporotic than in non-osteoporotic women. Likewise, subjects bearing the G allele in heterozygous or homozygous displayed lower values for lumbar bone mineral density and T score than those who did not present any G allele. The effect of confounders for osteoporosis on the association of G allele-osteoporosis was ruled out. In summary, we conclude that the G2014 polymorphism may become a useful marker for genetic studies of osteoporosis in the Mexican population.
- ItemChilean women's preferences regarding mode of delivery: which do they prefer and why?(2006) Angeja, A. C. E.; Washington, A. E.; Vargas, J. E.; Gomez, R.; Rojas, I.; Caughey, A. B.Objective Caesarean section rates in Chile are reported to be as high as 60% in some populations. The purpose of this study was to determine pregnant Chilean women's preferences towards mode of delivery.
- ItemFirst-trimester maternal serum PP13 in the risk assessment for preeclampsia(2008) Romero, R.; Kusanovic, J.P.; Than, N.G.; Erez, O.; Gotsch, F.; Espinoza, J.; Edwin, S.; Chefetz, I.; Gomez, R.; Nien, J.K.; Sammar, M.; Pineles, B.; Hassan, S.S.; Meiri, H.; Tal, Y.; Kuhnreich, I.; Papp, Z.; Cuckle, H.S.
- ItemProteomic analysis of amniotic fluid to identify women with preterm labor and intra-amniotic inflammation/infection: The use of a novel computational method to analyze mass spectrometric profiling(2008) Romero, R.; Espinoza, J.; Rogers, W.T.; Moser, A.; Kae Nien, J.; Pedro Kusanovic, J.; Gotsch, F.; Erez, O.; Gomez, R.; Edwin, S.; Hassan, S.S.
- ItemResistin: A hormone which induces insulin resistance is increased in normal pregnancy(2007) Nien, J.K.; Mazaki-Tovi, S.; Romero, R.; Kusanovic, J.P.; Erez, O.; Gotsch, F.; Pineles, B.L.; Friel, L.A.; Espinoza, J.; Goncalves, L.; Santolaya, J.; Gomez, R.; Hong, J.-S.; Edwin, S.; Soto, E.; Richani, K.; Mazor, M.; Hassan, S.S.
- ItemThe transcriptome of the fetal inflammatory response syndrome(2010) Madsen-Bouterse, S.A.; Romero, R.; Tarca, A.L.; Kusanovic, J.P.; Espinoza, J.; Kim, C.J.; Kim, J.-S.; Edwin, S.S.; Gomez, R.; Draghici, S.
- ItemTwin-to-twin transfusion syndrome: an antiangiogenic state?(2008) Kusanovic, J.P.; Romero, R.; Espinoza, J.; Nien, J.K.; Kim, C.J.; Mittal, P.; Edwin, S.; Erez, O.; Gotsch, F.; Mazaki-Tovi, S.; Than, N.G.; Soto, E.; Camacho, N.; Gomez, R.; Quintero, R.; Hassan, S.S.