Browsing by Author "Godoy, P."

Now showing 1 - 3 of 3
  • No Thumbnail Available
    Item
    Andes viral RNA load in chilean patients with Hantavirus Cardiopulmonary Syndrome
    (2008) Pablo, Vial A.; Mertz, G. J.; Ferrés, Marcela; Galeno, H.; Belmar, E.; Aldunate, R.; Castillo, C.; Noriega, L. M.; Tapia, M.; Donoso, S.; Ortega, C.; Navarro, E.; Arriagada, J. J.; Scholtz, L. A.; Ferrer, Pablo; Godoy, P.; Ibanez, R.; Hjelle, B.
  • No Thumbnail Available
    Item
    Evaluation of direct immunofluorescent assay (DFA) and rapid antigen test (RAT) for diagnosis of new pandemic influenza A H1N1 2009 (FLU AH1N1) during first wave in Santiago, Chile
    (ELSEVIER SCI LTD, 2010) Vizcaya, C.; Ferres, M.; Perret Pérez, Cecilia; Martinez, C.; Godoy, P.; Contreras, A. M.; Ferrer, P.; Azocar, T.
    Background: Since May 17th 2009 (epidemiological week 20th), the new strain of influenza A H1N1 was detected in respiratory samples of symptomatic patients in Santiago, Chile. The circulation of the virus lasted 11 weeks, with a peak between weeks 25-27th. The objective of our study was to evaluate the performance of influenza tests for diagnosis of FLU AH1N1. Methods: Nasopharyngeal swabs were taken from in and outpatients with influenza like illness (ILI), between June 1st and July 19th of 2009 (weeks 23-29th) and the results of DFA and RAT were compared using RT-PCR FLU AH1N1 (Light mix Kit Influenza A virus M2 and Light Mix Kit FLU A swine H1Ò of TIB MOLBIOL) as gold standard. We analyzed sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of DFA (D3 Ultra 8 DFA Respiratory & Identification Kit ä de Diagnostic Hybrid) and RAT (QuickVeuÒ of Biomerieux). Results were compared by age group and over three different periods of the outbreak: increasing, peak and decreasing. Results: 510 patients had RT-PCR for FLU AH1N1 with simultaneous DFA, 385 with RAT and 48 with both tests. Average age with DFA was 25,8 years (1 month-108 years, 53% females) and with RAT 32,9 years (2 months-108 years, 51% females), (p <0,0001). Comparing periods of the outbreak, DFA sensitivity was 58%, 77% and 81% in ascending, peak and descending period, respectively (p <0,001) and specificity was 90%, 83% and 91% respectively (p>0,05). Evaluating RAT, sensitivity was 41%, 61% and 67% (p<0,001) and specificity was 87%, 96% y 92% (p> 0,05) in different periods.
  • Thumbnail Image
    Item
    La vacuna polio oral en lactantes no interfiere con la detección de enterovirus en sangre
    (2013) González M.; Sandoval, C.; Valenzuela Contreras, Patricia; Montecinos, L.; Martínez, Constanza; Godoy, P.; Abarca Villaseca, Katia