Browsing by Author "Godoy, B."
Now showing 1 - 2 of 2
Results Per Page
Sort Options
- ItemFluid Distribution in the Central Andes Subduction Zone Imaged With Magnetotellurics(2019) Araya Vargas, Jaime; Meqbel, N. M.; Ritter, O.; Brasse, H.; Weckmann, U.; Yáñez Feliú, Guillermo Antonio; Godoy, B.
- ItemScavenger receptor class A ligands induce secretion of IL1β and exert a modulatory effect on the inflammatory activation of astrocytes in culture(2012) Godoy, B.; Murgas, P.; Tichauer, J.; Von Bernhardi, R.Class-A scavenger receptor (SR-A) is expressed by microglia, and we show here that it is also expressed by astrocytes, where it participates on their inflammatory activation. Astrocytes play a key role on the inflammatory response of the central nervous system, secreting several soluble mediators like cytokines and radical species. Exposure to SR ligands activated MAPKs and NF-kappa B signaling and increased production of IL1 beta and nitric oxide (NO). IL1 beta classically an inflammatory cytokine surprisingly did not increase but inhibited LPS + IFN gamma-induced NO production by astrocytes. Our results suggest that SRs expressed by astrocytes participate in the modulation of inflammatory activation. (C) 2012 Elsevier B.V. All rights reserved.