Browsing by Author "Glasinovic, JC"

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    Bile acids increase response and expression of human myometrial oxytocin receptor
    (MOSBY, INC, 2003) Germain, AM; Kato, S; Carvajal, JA; Valenzuela, GJ; Valdes, GL; Glasinovic, JC
    OBJECTIVE: We tested the hypothesis that during intrahepatic cholestasis of pregnancy bile acids activate the myometrial oxytocin receptor pathway.
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    Exploring the genetic role of the HLA-DPB1 locus in Chileans with intrahepatic cholestasis of pregnancy
    (1996) Mella, JG; Roschmann, E; Glasinovic, JC; Alvarado, A; Scrivanti, M; Volk, BA
    Background/Aims: Intrahepatic cholestasis of pregnancy is a rare disease of unknown etiology, with a strikingly higher prevalence in Chile than in most other countries, Although several studies suggest that a genetic predisposition is involved in the pathogenesis, no genetic disease-marker has so far been identified, Using a recently developed HLA-genotyping technique, we performed an association study with a highly polymorphic HLA class II gene in patients with recurrent intrahepatic cholestasis of pregnancy and normal control patients.
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    Increased orocecal transit time in patients with nonalcoholic fatty liver disease
    (2005) Soza, A; Riquelme, A; González, R; Alvarez, M; Pérez-Ayuso, RM; Glasinovic, JC; Arrese, M
    Intestinal bacterial overgrowth (IBO) has been suggested to play a pathogenic role in patients with nonalcoholic fatty liver disease (NAFLD). Delayed intestinal transit may contribute to IBO development. Ten nondiabetic patients with NAFLD and abnormal liver enzymes were recruited. Ten healthy individuals, matched by sex, age, and body mass index, were used as controls. Orocecal transit time (OCTT) was measured by the lactulose breath test. Anti-endotoxin core antibodies (EndoCAb) were determined. The effect of oral norfloxacin (400 mg BID during 2 weeks) on liver enzymes, lactulose breath test, and EndoCAb was also studied. NAFLD patients had higher basal breathed H, and prolonged OCTT compared to controls (127 +/- 61 vs. 57 +/- 23 min, respectively; P=0.0037). EndoCAb titers were similar in NAFLD patients and controls. Norfloxacin administration had no effect on ALT levels, lactulose breath test, or EndoCAb titers in patients with NAFLD. The present data show evidence of deranged intestinal motility in nondiabetic patients with NAFLD and support the hypothesis that NAFLD could be linked to endotoxin-induced liver damage of intestinal origin.