Browsing by Author "Garcia-Beltran, Olimpo"
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- ItemA selective fluorescent probe for the detection of mercury (II) in aqueous media and its applications in living cells(2012) Garcia-Beltran, Olimpo; Mena, Natalia; Berrios, Tania A.; Castro R., Enrique; Cassels, Bruce K.; Nuñez, Marco T.; Aliaga Miranda, Margarita Elly
- ItemAdsorptive Stripping Voltammetric Determination of Lead and Cadmium in Natural Waters in the Presence of Rutin Using a Nafion-Mercury Coated Film Electrode(2018) Arancibia Moya, Verónica; Nagles Vidal, Edgar Orlando; Garcia-Beltran, Olimpo; Hurtado Belalcazar, John Jady
- ItemAn unusual mulinane diterpenoid from the Chilean plant Azorella trifurcata (Gaertn) Pers(2014) Areche, Carlos; Sepulveda, Beatriz; San Martin, Aurelio; Garcia-Beltran, Olimpo; Simirgiotis, Mario; Canete, AlvaroFour new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13 alpha-hydroxyazorellane, 13 beta-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7 alpha-acetoxy-9-epi-13 beta-hydroxymulinane, possesses a new trans-syn-trans arrangement in a tricyclic ring system not previously encountered in nature. Among the mulinane diterpenoids isolated, mulin-11,13-dien-20-oic acid showed the gastroprotective effect on HCl-EtOH-induced gastric lesions in mice (ED50 = 55mg kg(-1)). Regarding the mode of gastroprotective action for this active compound, its effect was reduced by pre-treatment of the mice with indomethacin and N-ethylmaleimide, suggesting that prostaglandins and sulfhydryl compounds are positively involved in the gastroprotective activity using this model.
- ItemCoumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies(2021) Moya-Alvarado, Guillermo; Yanez, Osvaldo; Morales, Nicole; Gonzalez-Gonzalez, Angelica; Areche, Carlos; Nunez, Marco Tulio; Fierro, Angelica; Garcia-Beltran, OlimpoFourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an alpha,beta-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2H-chromen-2-ones). Both chalcones and coumarins are recognized scaffolds in medicinal chemistry, showing diverse biological and pharmacological properties among which neuroprotective activities and multiple enzyme inhibition, including mitochondrial enzyme systems, stand out. The evaluation of monoamine oxidase B (MAO-B) inhibitors has aroused considerable interest as therapeutic agents for neurodegenerative diseases such as Parkinson's. Of the fourteen chalcocumarins evaluated here against MAO-B, ChC4 showed the strongest activity in vitro, with IC50 = 0.76 +/- 0.08 mu M. Computational docking, molecular dynamics and MM/GBSA studies, confirm that ChC4 binds very stably to the active rMAO-B site, explaining the experimental inhibition data.
- ItemDetection of SO2 derivatives using a new chalco-coumarin derivative in cationic micellar media: application to real samples(2018) Gomez, Marisol; Aliaga Miranda, Margarita Elly; Arancibia Moya, Verónica; Moya, Alexis; Segura, Camilo; Nunez, Marco T.; Aguirre, Pabla; Nagles Vidal, Edgar Orlando; Garcia-Beltran, Olimpo
- ItemDevelopment of a microcomposite with single-walled carbon nanotubes and Nd2O3 for determination of paracetamol in pharmaceutical dosage by adsorptive voltammetry(2019) Arancibia Moya, Verónica; Penagos-Llanos, Johisner; Nagles Vidal, Edgar Orlando; Garcia-Beltran, Olimpo; Hurtado Belalcazar, John Jady
- ItemHost–guest interaction of coumarin-derivative dyes and cucurbit[7]uril : leading to the formation of supramolecular ternary complexes with mercuric ions(2015) Aliaga Miranda, Margarita Elly; Garcia-Rio, Luis; Pessego, Marcia; Montecinos Escobar, Rodrigo Andrés; Fuentealba Patiño, Denis Alberto; Uribe, Ivan; Martin-Pastor, Manuel; Garcia-Beltran, Olimpo