Browsing by Author "Garcia, P."

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    Comparative In Vitro Activity of Tigecycline Against Bacteria Recovered from Clinical Specimens in Latin America
    (2009) Bantar, C.; Curcio, D.; Canigia, L. Fernandez; Garcia, P.; Blanco, M. Guzman; Leal, A. L.
    The present study was performed to evaluate the in vitro activity of tigecycline in comparison to other agents against isolates recovered from patients hospitalized in Latin American. Organisms were collected in 47 clinical laboratories from 4 countries of Latin America between November 2005 and October 2006 and were tested by using disk diffusion method as described by the CLSI. A total of 7966 isolates were assessed. Tigecycline proved highly active against staphylococci and enterococci (>99% susceptibility). Imipenem was the most active agent against Escherichia coli (100% susceptibility), followed by tigecycline, 98.6% susceptibility. Resistance to cefotaxime in this species was 15.3%. Global tigecycline susceptibility of Klebsiella species was 90.2%, but the susceptibility rate was significantly slower in Venezuela (82%) than in Argentina, Colombia and Chile (93%) (p<0.01). Global cefotaxime resistance to Klebsiella spp. was 32.2% and carbapenem resistance was detected in all countries. By adopting a susceptible breakpoint >= 16mm, 91.3% of the Acinetobacter isolates proved susceptible to tigecycline. Results from the present study suggest that tigecycline may be a suitable option in Latin America, a region where multidrug resistance seems to be a dramatic, increasing problem and new antimicrobial choices are urgently needed.
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    Extracorporeal membrane oxygenation improves survival in a novel 24-hour pig model of severe acute respiratory distress syndrome
    (2016) Araos, J.; Alegría Aguirre, Luz Katiushka; Garcia, P.; Damiani Rebolledo, L. Felipe; Tapia, P.; Soto, D.; Salomon, T.; Retamal Montes, Jaime; Bugedo Tarraza, Guillermo; Bruhn, Alejandro; Rodriguez, F.; Amthauer, M.; Erranz, B.; Castro, G.; Carreno, P.; Medina, T.; Cruces, P.
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    Genome-wide methylation profiling reveals Zinc finger protein 516 (ZNF516) and FK-506- binding protein 6 (FKBP6) promoters frequently methylated in cervical neoplasia, associated with HPV status and ethnicity in a Chilean population
    (2014) Brebi, P.; Maldonado, L.; Noordhuis, M.; Ili, C.; Leal, P.; Garcia, P.; Brait, M.; Ribas, J.; Michailidi, C.; Roa Strauch, Juan Carlos Enrique
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    Kinetics and mechanisms of the reactions of 4-nitro- and 3-nitrophenyl 4-methylphenyl thionocarbonates with alicyclic amines and pyridines
    (2000) Castro R., Enrique; Garcia, P.; Leandro Arriagada, Leonardo Salvador; Quesieh, N.; Rebolledo, A.; Santos Blanco, José Guillermo
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    Low Spontaneous Breathing Effort during Extracorporeal Membrane Oxygenation in a Porcine Model of Severe Acute Respiratory Distress Syndrome
    (2020) Dubo, S.; Oviedo, V.; Garcia, A.; Alegría Aguirre, Luz Katiushka; Garcia, P.; Valenzuela, E. D.; Damiani Rebolledo, L. Felipe; Araos, J.; Medina, T.; Retamal Montes, Jaime; Bachmann, M. C.; Basoalto, R.; Bravo, S.; Soto, D.; Cruces, P.; Guzman, P.; Cornejo, R.; Bugedo Tarraza, Guillermo; Brebi, P.; Bruhn, Alejandro
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    M-protein gene-type distribution and hyaluronic acid capsule in group A Streptococcus clinical isolates in Chile: association of emm gene markers with csrR alleles
    (CAMBRIDGE UNIV PRESS, 2012) Wozniak, A.; Rojas, P.; Rodriguez, C.; Undabarrena, A.; Garate, C.; Riedel, I.; Roman, J. C.; Kalergis, A. M.; Garcia, P.
    Streptococcus pyogenes causes a variety of infections because of virulence factors such as capsular hyaluronic acid and M protein. The aim of this study was to determine emm types and capsule phenotype in 110 isolates of S. pyogenes from patients with invasive (sterile sites) and non-invasive (mainly pharyngitis) infections in Chile, and the relationship between both virulence factors. The most abundant types found were emm12, emm1, emm4 and emm28 and their distribution was similar to that seen in Latin America and developed countries, but very different from that in Asia and Pacific Island countries. Ten of 16 emm types identified in pharyngeal isolates were found in sterile-site isolates, and three of nine emm types of sterile-site isolates occurred in pharyngeal isolates; three emm subtypes were novel. The amount of hyaluronic acid was significantly higher in sterile-site isolates but did not differ substantially among emm types. Only three isolates were markedly capsulate and two of them had mutations in the csrR gene that codes for a repressor of capsule synthesis genes. We found a non-random association between emm types and csrR gene alleles suggesting that horizontal gene transfer is not freely occurring in the population.
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    Mucin 5B, carbonic anhydrase 9 and claudin 18 are potential theranostic markers of gallbladder carcinoma
    (2019) Espinoza, J.A.; Riquelme, I.; Sagredo, E.A.; Rosa, L.; Garcia, P.; Bizama, Carolina; Apud-Bell, M.; Leal, P.; Weber, H.; Benavente, F.; Vargas, S.; Romero, D.; Kalergis Parra, Alexis Mikes; Roa Strauch, Juan Carlos Enrique
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    Near-apneic ventilation decreases lung injury and fibroproliferation in an acute respiratory distress syndrome model with extracorporeal membrane oxygenation
    (2019) Araos, J.; Alegría Aguirre, Luz Katiushka; Garcia, P.; Cruces, P.; Soto, D.; Erranz, B.; Amthauer, M.; Ayala, Pedro; Borzone, Gisella; Damiani Rebolledo, L. Felipe
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    Preparing for low surface brightness science with the Vera C. Rubin Observatory: Characterization of tidal features from mock images
    (2022) Martin, G.; Bazkiaei, A. E.; Spavone, M.; Iodice, E.; Mihos, J. C.; Montes, M.; Benavides, J. A.; Brough, S.; Carlin, J. L.; Collins, C. A.; Duc, P. A.; Gomez, F. A.; Galaz, G.; Hernandez-Toledo, H. M.; Jackson, R. A.; Kaviraj, S.; Knapen, J. H.; Martinez-Lombilla, C.; McGee, S.; O'Ryan, D.; Prole, D. J.; Rich, R. M.; Roman, J.; Shah, E. A.; Starkenburg, T. K.; Watkins, A. E.; Zaritsky, D.; Pichon, C.; Armus, L.; Bianconi, M.; Buitrago, F.; Busa, I; Davis, F.; Demarco, R.; Desmons, A.; Garcia, P.; Graham, A. W.; Holwerda, B.; Hon, D. S-H; Khalid, A.; Klehammer, J.; Klutse, D. Y.; Lazar, I; Nair, P.; Noakes-Kettel, E. A.; Rutkowski, M.; Saha, K.; Sahu, N.; Sola, E.; Vazquez-Mata, J. A.; Vera-Casanova, A.; Yoon, I
    Tidal features in the outskirts of galaxies yield unique information about their past interactions and are a key prediction of the hierarchical structure formation paradigm. The Vera C. Rubin Observatory is poised to deliver deep observations for potentially millions of objects with visible tidal features, but the inference of galaxy interaction histories from such features is not straightforward. Utilizing automated techniques and human visual classification in conjunction with realistic mock images produced using the NewHorizon cosmological simulation, we investigate the nature, frequency, and visibility of tidal features and debris across a range of environments and stellar masses. In our simulated sample, around 80 per cent of the flux in the tidal features around Milky Way or greater mass galaxies is detected at the 10-yr depth of the Legacy Survey of Space and Time (30-31 mag arcsec(-2)), falling to 60 per cent assuming a shallower final depth of 29.5 mag arcsec(-2). The fraction of total flux found in tidal features increases towards higher masses, rising to 10 per cent for the most massive objects in our sample (M-* similar to 10(11.5) M-circle dot). When observed at sufficient depth, such objects frequently exhibit many distinct tidal features with complex shapes. The interpretation and characterization of such features varies significantly with image depth and object orientation, introducing significant biases in their classification. Assuming the data reduction pipeline is properly optimized, we expect the Rubin Observatory to be capable of recovering much of the flux found in the outskirts of Milky Way mass galaxies, even at intermediate redshifts (z < 0.2).
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    Socioeconomic factors associated with antimicrobial resistance in Latin America: A systematic review and empirical analysis of 41 Chilean hospitals
    (ELSEVIER SCI LTD, 2020) Allel, K.; Garcia, P.; Labarca, J.; Rendic, M.; Munita, J.; Undurraga, E.