Browsing by Author "Galgani Fuentes, José"
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- ItemAdipose tissue expression of adipose (WDTC1) gene is associated with lower fat mass and enhanced insulin sensitivity in humans(2013) Galgani Fuentes, José; Kelley, David E.; Albu, Jeanine B.; Krakoff, Jonathan; Smith, Steven R.; Bray, George A.; Ravussin, Eric
- ItemAnthropometric and blood pressure changes in patients with or without nutritional counselling during cardiac rehabilitation: a retrospective study(2021) Valentino Peirano, Giovanna Francesca; Galgani Fuentes, José; Álamos Ramírez, Mirelly de los Ángeles; Orellana Bustos, Lorena; Adasme Peña, Marcela Alejandra Berríos, A.; Acevedo B., Mónica
- ItemAssessment of the Role of Metabolic Determinants on the Relationship between Insulin Sensitivity and Secretion(2016) Galgani Fuentes, José; Gómez, Carmen; Mizgier Rojas, María Luisa; Gutiérrez, Juan; Santos Martín, José Luis; Olmos Coelho, Pablo Roberto; Mari, Andrea
- ItemAssociation between zinc nutritional status and glycemic control in individuals with well-controlled type-2 diabetes(2018) Perez, Alvaro; Rojas, Pamela; Carrasco, Fernando; Basfi-Fer, Karen; Perez-Bravo, Francisco; Codoceo, Juana; Inostroza, Jorge; Galgani Fuentes, José; Gilmore, L. Anne; Ruz, Manuel
- ItemAssociation of metabolic flexibility indexes after an oral glucose tolerance test with cardiometabolic risk factors(2023) Alcantara, Juan M. A.; Galgani Fuentes, José© 2023, The Author(s), under exclusive licence to Springer Nature Limited.Background & aims: Metabolic flexibility (MetF) is considered a metabolic health biomarker, as excess body weight is associated with lower MetF. We aimed to identify whether MetF indexes were associated with cardiometabolic risk factors before and after adjustment for body size-related factors (body weight, fat-free mass, and resting metabolic rate). Methods: We studied 51 participants (55% women; 33.6 ± 8.7 years; 26.3 ± 3.8 kg/m²) who consumed a 75-g glucose load. We measured gas exchange before (fasting) and for 3 h after glucose ingestion. MetF indexes were assessed, including the change after each hour and the 3-hour incremental area under the curve (iAUC) in respiratory exchange ratio (RER). These indexes were then related to cardiometabolic risk factors before and after adjusting for body size-related factors. Results: MetF indexes correlated with each other (r ≥ 0.51; P < 0.001) and related to body weight (adjusted R2 ≥ 0.09; P < 0.03). A similar pattern was noted for fat-free mass and resting metabolic rate. MetF, regardless of the index, was not related to cardiometabolic risk factors except to BMI and high-density lipoprotein-cholesterol (HDL-C). The association between BMI and MetF disappeared after adjusting for body size-related factors. Similar adjustments did not modify the association between HDL-C and MetF, especially when approached by the change in RER after the first hour (adjusted R2 = 0.20–0.22; all P < 0.02). Conclusions: Inter-individual body size differences fully accounted for the associations between BMI and MetF. However, variability in body size-related factors appeared less relevant in affecting the associations of other cardiometabolic risk factors with MetF.
- ItemBaseline body fat percentage is associated to weight and fat mass gain from high-fat overfeeding over 8 weeks(2025) Galgani Fuentes, José; Fernández Verdejo, Rodrigo; Bray, George A.; Smith, Steven R.; Ghosh, Sujoy; Javvadi, Pravalika; Ravussin, EricBackground & aims: Epidemiological data suggest that participants with lower vs. higher body mass index (BMI) resist exposure to the obesogenic environment. To test this, we analyzed the relationship between overfeeding-induced weight and fat mass gains with baseline BMI and body fat percentage.Methods: In this controlled intervention study, 34 men (age: 26±5 y old; BMI: 25.5±2.4 kg/m2, body fat [DXA]: 19.3±5.1%) consumed for 8 weeks 40% more energy than needed at weight maintenance. The energy costs of weight and fat mass gain were calculated as the 8-week excess energy consumed divided by weight or fat mass gain. Energy expenditure (baseline and after overfeeding) was determined using a metabolic chamber and doubly labeled water. Transcriptomic analysis was conducted from abdominal subcutaneous adipose tissue samples.Results: Body weight increased 7.2±2.1 kg and fat mass 4.0±1.4 kg. There was no statistical association between baseline BMI and weight and fat mass gains. However, baseline body fat percentage was significantly associated with weight (r=0.57) and fat mass (r=0.59) gains. Body fat percentage was also statistically associated with energy cost of weight (r=-0.38) and fat mass (r=-0.40) gains. Metabolic adaptation in energy expenditure (adaptive thermogenesis) was unrelated to the energy cost of weight and fat mass gains. Transcriptomics analysis showed that high energy cost of weight gain was associated with up-regulation of inflammation-related pathways.Conclusion: Body fat percentage at baseline was inversely associated with overfeeding-induced weight and fat gain resistance. The underlying compensatory response appears unrelated to changes in energy expenditure
- ItemCarbohydrate, fat and protein metabolism in obesity(2015) Galgani Fuentes, José; Cortés Mora, Víctor Antonio; Carrasco, Fernando; Ahima, Rexford S.
- ItemCold-induced shivering for metabolic health(Springer Nature, 2024) Fernández Verdejo, Rodrigo; Galgani Fuentes, JoséThis proof-of-concept study shows that 1 hour of cold exposure with shivering for 10 consecutive days improves glucose tolerance and other metabolic health outcomes in humans with overweight or obesity.
- ItemConcordancia entre calorimetría indirecta y modelos predictivos en una población sana española(2015) Cruz Marcos, Sandra de la; Mateo Silleras, Beatriz de; Camina Martín, Ma. Alicia; Carreño Enciso, Laura; Miján de la Torre, Alberto; Galgani Fuentes, José; Redondo del Río, María Paz
- ItemContribution of brown adipose tissue to human energy metabolism(2019) Fernández Verdejo, Rodrigo; Marlatt, Kara L.; Ravussin, Eric; Galgani Fuentes, José
- ItemDefective natriuretic peptide receptor signaling in skeletal muscle links obesity to type 2 diabetes(2015) Coue, M.; Badin, P.; Vila, I.; Laurens, C.; Louche, K.; Marques, M.; Bourlier, V.; Mouisel, E.; Tavernier, G.; Galgani Fuentes, José; Rustan, A.; Joanisse, D.; Smith, S. R.; Langin, D.; Moro, C.
- ItemDevelopment and assessment of the disposition index based on the oral glucose tolerance test in subjects with different glycaemic status(2016) Santos Martín, José Luis; Yévenes, I.; Cataldo Bascuñan, Luis Rodrigo; Morales, M.; Galgani Fuentes, José; Arancibia, C.; Vega, J.; Olmos Coelho, Pablo Roberto; Flores, M.; Valderas Igor, Juan Patricio; Pollak, F.
- ItemDirect Relationship Between Metabolic Flexibility Measured During Glucose Clamp and Prolonged Fast in Men(2020) Fernández Verdejo, Rodrigo; Castro Sepúlveda, Mauricio; Gutierrez-Pino, J.; Malo-Vintimilla, L.; López Fuenzalida, Antonio Eduardo; Olmos Coelho, Pablo Roberto; Santos Martín, José Luis; Galgani Fuentes, José
- ItemEffect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion(2017) Mizgier Rojas, María Luisa; Cataldo Bascuñan, Luis Rodrigo; Gutiérrez, J.; Santos Martín, José Luis; Galgani Fuentes, José; Casas, M.; Llanos, P.; Contreras, A.; Moro, C.; Bouzakri, K.
- ItemEnlarged adipocytes in subcutaneous adipose tissue associated to hyperandrogenism and visceral adipose tissue volume in women with polycystic ovary syndrome(2018) Echiburú, Bárbara; Pérez Bravo, Francisco; Galgani Fuentes, José; Sandoval, Daniel; Saldías, Carolina; Crisosto, Nicolás; Maliqueo, Manuel; Sir-Petermann, Teresa
- ItemEvaluación de la ingesta dietética y excreción urinaria de sodio y potasio en adultos(2014) Cornejo, Karen; Pizarro, Fernando; Atalah, Eduardo; Galgani Fuentes, José
- ItemEvaluación de la insulinemia post carga oral de glucosa como método diagnóstico de resistencia a la insulina(2014) Arancibia, Constanza; Galgani Fuentes, José; Valderas Igor, Juan Patricio; Morales, Mauricio; Santos Martin, José Luis; Pollak Cornejo, FelipeBackground: In our country, the assessment of insulin resistance (IR) measuring serum insulin levels at 60 and 120 minutes after a 75 g oral glucose tolerance test (OGTT), is usual. However, there is no information about the distribution of serum insulin levels in the Chilean population. Aim: To assess the distribution of serum insulin levels at 60 and 120 minutes during OGTTs and suggest a statistical cut-off point to estimate the degree of IR. Material and Methods: Retrospective analysis of 1815 OGTTs performed in non-diabetic subjects aged between 18 and 75 years, at a university medical center. HOMA-IR (Homeostasis Model Assessment), insulin sensitivity index of Matsuda (ISI-Composite), and their correlation with serum insulin levels at 60 and 120 minutes were calculated. Results: The 75th percentiles for serum insulin levels at 60 and 120 minutes were 127 and 81 μU/mL, respectively. There was a high correlation between HOMA-IR and ISI-Composite (r = -089, p < 0.001). There was a weaker although significant correlation between HOMA-IR and ISI-Composite and insulin levels at 60 (r = 0.56 and -0.79 respectively, p < 0,001) and 120 minutes (r = 0.54 and -0.75 respectively, p < 0,001). Conclusions: We propose 60 and 120 min serum insulin levels of 130 and 80 μU/mL respectively, as cut-off values for normality during OGTT in Chilean normoglycemic individuals.
- ItemFluoxetine Impairs Insulin Secretion without Modifying Extracellular Serotonin Levels in MIN6 β-cells(2015) Cataldo Bascuñan, Luis Rodrigo; Cortés Mora, Víctor Antonio; Mizgier Rojas, María Luisa; Aranda, E.; Mezzano, Diego; Olmos Coelho, Pablo Roberto; Galgani Fuentes, José; Suazo, J.; Santos Martín, José Luis
- ItemHepatocyte expression of the micropeptide adropin regulates the liver fasting response and is enhanced by caloric restriction(2020) Banerjee, S.; Ghoshal, S.; Stevens, J. R.; McCommis, K. S.; Gao, S.; Castro Sepúlveda, Mauricio; Mizgier Rojas, María Luisa; Girardet, C.; Kumar, K. G.; Galgani Fuentes, José; Niehoff, M. L.; Farr, S. A.; Zhang, J. S.; Butler, A. A.
- ItemII Consenso de la Sociedad Chilena de Endocrinología y Diabetes sobre resistencia a la insulina(2015) Pollak Cornejo, Felipe; Araya, Verónica; Lanas, Alejandra; Arrese Jiménez, Marco; Galgani Fuentes, José; García Bruce, Hernán; Maiz Gurruchaga, Manuel Alberto; Valderas Igor, Juan Patricio; Villaseca Délano, Paulina
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